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Year Report for: 2000

Abbott_2000_Eur.J.Biochem_267_6140Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8
Abdalla_2000_Mol.Cell.Endocrinol_160_17Effect of estrogen on intracellular signaling pathways linked to activation of M(2)- and M(3)-muscarinic acetylcholine receptors in the rat myometrium
Abe_2000_J.Gastroenterol_35_28Focal therapeutic efficacy of transcatheter arterial infusion of styrene maleic acid neocarzinostatin for hepatocellular carcinoma
Abgrall_2000_Aquaculture_181_1Sublethal effects of azamethiphos on shelter use by juvenile lobsters (Homarus americanus)
Abi-Gerges_2000_J.Physiol_523 Pt 2_377Functional expression and regulation of the hyperpolarization activated non-selective cation current in embryonic stem cell-derived cardiomyocytes
Abou-Hatab_2000_Arch.Gerontol.Geriatr_31_193Plasma esterase activities in young and old patients undergoing open inguinal hernia repair
Abraham_2000_J.Neuroendocrinol_12_486Chronic corticosterone administration dose-dependently modulates Abeta(1-42)- and NMDA-induced neurodegeneration in rat magnocellular nucleus basalis
Adams_2000_J.Cell.Biol_150_1385Absence of alpha-syntrophin leads to structurally aberrant neuromuscular synapses deficient in utrophin
Adams_2000_J.Neurochem_75_2277The A-type potassium channel Kv4.2 is a substrate for the mitogen-activated protein kinase ERK
Adams_2000_J.Neuroendocrinol_12_Autho Adams T#SNew pharmacological treatments for Alzheimer's disease: implications for dementia care nursing
Adams_2000_Science_287_2185The genome sequence of Drosophila melanogaster
Adel-Patient_2000_J.Immunol.Methods_235_21Evaluation of a high IgE-responder mouse model of allergy to bovine beta-lactoglobulin (BLG): development of sandwich immunoassays for total and allergen-specific IgE, IgG1 and IgG2a in BLG-sensitized mice
Adhami_2000_Neurotoxicol.Teratol_22_41Intrahippocampal cholinergic-rich transplants restore lead-induced deficits: a preliminary study in rats
Agarwala_2000_Biochem.Biophys.Res.Commun_272_641Phosphorylation of RTP, an ER stress-responsive cytoplasmic protein
Agmo_2000_IDrugs_3_743International Behavioral Neuroscience Society - ninth annual meeting
Aguera_2000_Analyst_125_1397Splitless large-volume GC-MS injection for the analysis of organophosphorus and organochlorine pesticides in vegetables using a miniaturised ethyl acetate extraction
Ahmadi_2000_Biochem.Biophys.Res.Commun_269_676GSTM1 and mEPHX polymorphisms in Parkinson's disease and age of onset
Ahren_2000_Eur.J.Pharmacol_404_239Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice
Aitcheson_2000_Aquaculture_183_269Removal of aquaculture therapeutants by carbon adsorption: 1. Equilibrium adsorption behaviour of single components
Aizawa_2000_Respiration_67_652Histamine-induced increase in isometric tension of smooth muscle is mediated by local vagus nerve in human bronchus
Akaaboune_2000_Mol.Cell.Neurosci_15_355Developmental regulation of amyloid precursor protein at the neuromuscular junction in mouse skeletal muscle
Akici_2000_Eur.J.Pharmacol_388_115Further evidence for the heterogeneity of functional muscarinic receptors in guinea pig gallbladder
Akiyama_2000_Cardiovasc.Res_46_531Adrenergic inhibition of endogenous acetylcholine release on postganglionic cardiac vagal nerve terminals
Alagiakrishnan_2000_Hawaii.Med.J_59_57Use of donepezil in elderly patients with Alzheimer's disease--a Hawaii based study
Alami-Durante_2000_J.Exp.Biol_203_3675Effects of environmental temperature on the development of the myotomal white muscle in larval carp (Cyprinus carpio L.)
Alberi_2000_Brain.Res_872_11Involvement of calmodulin-dependent protein kinase II in carbachol-induced rhythmic activity in the hippocampus of the rat
Albuquerque_2000_Behav.Brain.Res_113_131Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance
Albuquerque_2000_Handb.Exp.Pharmacol_144_337Neuronal Nicotinic Receptors and Synaptic Transmission in the Mammalian Central Nervous System
Alhomida_2000_Toxicology_147_33Kinetic analysis of the toxicological effect of tacrine (Cognex) on human retinal acetylcholinesterase activity
Ali_2000_J.Pharm.Pharmacol_52_1297Effect of Rhazya stricta Decne on monoamine oxidase and cholinesterase activity and brain biogenic amine levels in rats
Alkondon_2000_Eur.J.Pharmacol_393_59alpha7 nicotinic acetylcholine receptors and modulation of gabaergic synaptic transmission in the hippocampus
Alkondon_2000_J.Neurosci_20_66Nicotinic receptor activation in human cerebral cortical interneurons: a mechanism for inhibition and disinhibition of neuronal networks
Alkondon_2000_Neuropharmacol_39_2726Nicotine at concentrations found in cigarette smokers activates and desensitizes nicotinic acetylcholine receptors in CA1 interneurons of rat hippocampus
Allman_2000_Mol.Pharmacol_58_175Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M(1) muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine
Almeida_2000_Neuropharmacol_39_2740The opioid antagonist naltrexone inhibits activity and alters expression of alpha7 and alpha4beta2 nicotinic receptors in hippocampal neurons: implications for smoking cessation programs
Alonso-Villalobos_2000_J.Vet.Med.B.Infect.Dis.Vet.Public.Health_47_1The in vitro secretion of acetylcholinesterase by adult stages of Heligmosomoides polygyrus: the effects of broad-spectrum anthelmintics
Altamirano_2000_J.Neurochem_74_869The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme
Alvarez-Arcaya_2000_Acta.Neurol.Scand_102_350The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women
Amada_2000_Biochim.Biophys.Acta_1478_201Overproduction in Escherichia coli, purification and characterization of a family I.3 lipase from Pseudomonas sp. MIS38
Amador_2000_N.C.Med.J_61_209Where we stand with treating dementia
Ambrus_2000_Food.Addit.Contam_17_519Within and between field variability of residue data and sampling implications
Amouyal-Barkate_2000_Ann.Pharmacother_34_1347Abnormal movements with donepezil in Alzheimer disease
Andberg_2000_Biochem.J_345 Pt 3_621Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin
Andersson_2000_Food.Addit.Contam_17_547Comparison of pesticide residues in composite samples and in individual units: the Swedish approach to sampling
Andreani_2000_Eur.J.Med.Chem_35_774-Aminopyridine derivatives with antiamnesic activity
Angeli_2000_Pharm.Acta.Helv_74_131Receptors in neurodegenerative diseases, muscarinic cholinergic receptors
Antil-Delbeke_2000_J.Biol.Chem_275_29594Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor
Aparicio_2000_Chem.Biol_7_895A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis
Aparicio_2000_Trends.Genet_16_54Vertebrate evolution: recent perspectives from fish
Arahira_2000_Eur.J.Biochem_267_2649Purification, molecular cloning and ethylene-inducible expression of a soluble-type epoxide hydrolase from soybean (Glycine max [L.] Merr.)
Araki_2000_Cytotech_33_93Transgenic rabbits expressing human lipoprotein lipase
Aramakis_2000_J.Neurosci_20_6106A critical period for nicotine-induced disruption of synaptic development in rat auditory cortex
Arca_2000_Clin.Genet_58_369The common mutations in the lipoprotein lipase gene in Italy: effects on plasma lipids and angiographically assessed coronary atherosclerosis
Argiriadi_2000_J.Biol.Chem_275_15265Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation
Armengaud_2000_Brain.Res_859_390Functional cytochrome oxidase histochemistry in the honeybee brain
Armstrong_2000_Drug.Metab.Rev_32_327New structural and chemical insight into the catalytic mechanism of epoxide hydrolases
Arneric_2000_Handb.Exp.Pharmacol_144_419Agonists and Antagonists of Nicotinic Acetylcholine Receptors
Arsan_2000_Biotechnol.Bioeng_69_222Selectivity of Rhizomucor miehei lipase as affected by choice of cosubstrate system in ester modification reactions in organic media
Aschner_2000_Neurotoxicol_21_175Interactions between pesticides and glia: an unexplored experimental field
Ashery_2000_EMBO.J_19_3586Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells
Atoji_2000_Auton.Neurosci_84_1Innervation of the pigeon oviduct: correlation of NADPH diaphorase with acetylcholinesterase, tyrosine hydroxylase, and neuropeptides
Atta_2000_J.Nat.Prod_63_1393New norditerpenoid alkaloids from Aconitum falconeri
Audsley_2000_Insect.Biochem.Mol.Biol_30_681Juvenile hormone biosynthesis by corpora allata of larval tomato moth, Lacanobia oleracea, and regulation by Manduca sexta allatostatin and allatotropin
Auld_2000_J.Pharmacol.Exp.Ther_292_692Pharmacological characterization of endogenous acetylcholine release from primary septal cultures
Aura_2000_Eur.J.Pharmacol_390_313Pre-training blocks the improving effect of tetrahydroaminoacridine and D-cycloserine on spatial navigation performance in aged rats
Aurilia_2000_Microbiology_146_1391Three multidomain esterases from the cellulolytic rumen anaerobe Ruminococcus flavefaciens 17 that carry divergent dockerin sequences.
Avasthi_2000_J.Assoc.Physicians.India_48_794Serial neuro-electrophysiological studies in acute organophosphate poisoning--correlation with clinical findings, serum cholinesterase levels and atropine dosages
Aviram_2000_Am.J.Clin.Nutr_71_1062Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice
Aviram_2000_Circulation_101_2510Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities
Aviram_2000_Free.Radic.Res_33 Suppl_S85Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases
Babic_2000_Age.Ageing_29_370Spontaneous rupture of oesophagus (Boerhaave's syndrome) related to rivastigmine
Bachmann_2000_Biosens.Bioelectron_15_193Improved multianalyte detection of organophosphates and carbamates with disposable multielectrode biosensors using recombinant mutants of Drosophila acetylcholinesterase and artificial neural networks
Baenziger_2000_J.Biol.Chem_275_777Effect of membrane lipid composition on the conformational equilibria of the nicotinic acetylcholine receptor
Bai_2000_Curr.Med.Chem_7_355Huperzine A, a potential therapeutic agent for treatment of Alzheimer's disease
Bailey_2000_Arch.Toxicol_74_322Association of azinphos-methyl with rat erythrocytes and hemoglobin
Bailey_2000_Can.J.Clin.Pharmacol_7_198Antidote availability in Quebec hospital pharmacies: impact of N-acetylcysteine and naloxone consumption
Bailey_2000_Proc.Natl.Acad.Sci.U.S.A_97_11581A novel function for serotonin-mediated short-term facilitation in aplysia: conversion of a transient, cell-wide homosynaptic hebbian plasticity into a persistent, protein synthesis-independent synapse-specific enhancement
Bainy_2000_Aquaculture_191_163Biochemical responses in penaeids caused by contaminants
Baladi_2000_Clin.Ther_22_1549Rivastigmine for Alzheimer's disease: Canadian interpretation of intermediate outcome measures and cost implications
Balestra_2000_J.Neuroimmunol_102_89Antibodies against neuronal nicotinic receptor subtypes in neurological disorders
Balestra_2000_Mol.Pharmacol_58_300Chick optic lobe contains a developmentally regulated alpha2alpha5beta2 nicotinic receptor subtype
Ballard_2000_Ann.Neurol_48_868Delusions associated with elevated muscarinic binding in dementia with Lewy bodies
Bandmann_2000_J.Biotechnol_79_161Genetic engineering of the Fusarium solani pisi lipase cutinase for enhanced partitioning in PEG-phosphate aqueous two-phase systems
Banu_2000_Mol.Microbiol_35_854Identification of novel VirR/VirS-regulated genes in Clostridium perfringens
Baptista_2000_Biotechnol.Bioeng_70_699Trehalose delays the reversible but not the irreversible thermal denaturation of cutinase
Barak_2000_Biochemistry_39_1156Evidence for P-N bond scission in phosphoroamidate nerve agent adducts of human acetylcholinesterase
Barbier_2000_Int.Microbiol_3_117Esterases in marine dinoflagellates and resistance to the organophosphate insecticide parathion
Barnes_2000_Chest_117_63SThe pharmacological properties of tiotropium
Barnes_2000_Neurosci_99_17Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors
Barrantes_2000_Kidney.Int_57_1382Nongenomic effects of steroids on the nicotinic acetylcholine receptor
Barresi_2000_Development_127_2189The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity
Bartels_2000_Biochem.Pharmacol_60_479Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma
Bartolomeo_2000_J.Pharmacol.Exp.Ther_292_584The preclinical pharmacological profile of WAY-132983, a potent M1 preferring agonist
Barton_2000_Semin.Neurol_20_7Ocular aspects of myasthenia gravis
Basova_2000_Zh.Evol.Biokhim.Fiziol_36_97[Kinetic analysis of the 'substrate protective effect' for cholinesterases of various origin]
Bass_2000_Cell_101_235Double-stranded RNA as a template for gene silencing
Bassant_2000_Eur.J.Pharmacol_387_151Sustained effect of metrifonate on cerebral glucose metabolism after immunolesion of basal forebrain cholinergic neurons in rats
Bawden_2000_Virology_274_120Complete Genomic Sequence of the Amsacta moorei Entomopoxvirus: Analysis and Comparison with Other Poxviruses.
Bazin_2000_Presse.Med_29_871[Alzheimer type dementia: is early diagnosis significant?]
Beare_2000_Med.J.Aust_172_96Organophosphate poisoning versus brainstem stroke
Beattie_2000_Development_127_2653Mutations in the stumpy gene reveal intermediate targets for zebrafish motor axons
Beaumont_2000_Nat.Neurosci_3_133Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels
Begun_2000_Proc.Natl.Acad.Sci.U.S.A_97_5960Reduced X-linked nucleotide polymorphism in Drosophila simulans
Beisson_2000_Biochem.Soc.Trans_28_773Assaying Arabidopsis lipase activity
Beja_2000_Science_289_1902Bacterial rhodopsin: evidence for a new type of phototrophy in the sea
Belkner_2000_Biochem.J_352 Pt 1_125Macrophage cholesteryl ester hydrolases and hormone-sensitive lipase prefer specifically oxidized cholesteryl esters as substrates over their non-oxidized counterparts
Bell_2000_Br.J.Pharmacol_131_1135Histamine depolarizes cholinergic interneurones in the rat striatum via a H(1)-receptor mediated action
Bellingham_2000_Clin.Exp.Pharmacol.Physiol_27_132Cholinergic modulation of respiratory brain-stem neurons and its function in sleep-wake state determination
Bellizzi_2000_Proc.Natl.Acad.Sci.U.S.A_97_4573The crystal structure of palmitoyl protein thioesterase 1 and the molecular basis of infantile neuronal ceroid lipofuscinosis
Bello-Ramirez_2000_Toxicology_149_63A theoretical approach to the mechanism of biological oxidation of organophosphorus pesticides
Belmahdi_2000_Hum.Mutat_16_450Identification of 6 new polymorphisms, g.11177G>A, g.14622C>T (R49C), g.17540T>C, g.17639T>C, g.30929T>C, g.31074G>A (R454Q), in the human microsomal epoxide hydrolase gene (EPHX1) in a French population
Belmonte_2000_J.Neurosci_20_8417Developmental expression of muscarinic acetylcholine receptors in chick retina: selective induction of M2 muscarinic receptor expression in ovo by a factor secreted by muller glial cells
Ben_2000_Photochem.Photobiol_71_124Porphyrins and related compounds as photoactivatable insecticides. 3. Laboratory and field studies
Bender_2000_Life.Sci_66_1675Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors
Benhammou_2000_Neuropharmacol_39_2818[(3)H]Nicotine binding in peripheral blood cells of smokers is correlated with the number of cigarettes smoked per day
Bennett_2000_Neuropharmacol_39_523The concept of transmitter receptors: 100 years on
Bentley_2000_Chem.Rev_100_3801Mycophenolic Acid: a one hundred year odyssey from antibiotic to immunosuppressant
Bercik_2000_Gastroenterology_119_386Quantitative analysis of intestinal motor patterns: spatiotemporal organization of nonneural pacemaker sites in the rat ileum
Berg_2000_Handb.Exp.Pharmacol_144_247Nicotinic Acetylcholine Receptors in Ganglionic Transmission
Berggren_2000_Biochim.Biophys.Acta_1481_317Substitutions of surface amino acid residues of cutinase probed by aqueous two-phase partitioning
Berggren_2000_J.Chromatogr.B.Biomed.Sci.Appl_743_295Partitioning of peptides and recombinant protein-peptide fusions in thermoseparating aqueous two-phase systems: effect of peptide primary structure
Berman_2000_J.Neurosci_20_7017The role of identified neurotransmitter systems in the response of insular cortex to unfamiliar taste: activation of ERK1-2 and formation of a memory trace
Bertolini_2000_Clin.Genet_57_140Pseudodominance of lipoprotein lipase (LPL) deficiency due to a nonsense mutation (Tyr302>Term) in exon 6 of LPL gene in an Italian family from Sardinia (LPL(Olbia))
Betz_2000_J.Basic.Microbiol_40_7Molecular cloning, sequencing, expression, and site-directed mutagenesis of the 1H-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase gene from Arthrobacter spec. Ru61a
Bhaskaran_2000_J.Assoc.Physicians.India_48_439Familial infantile myaesthenia
Bhattacharjee_2000_J.Mol.Recognit_13_213Molecular similarity analysis between insect juvenile hormone and N, N-diethyl-m-toluamide (DEET) analogs may aid design of novel insect repellents
Bhattacharya_2000_Indian.J.Exp.Biol_38_753Signal transduction by xenobiotics in fish
Biagioni_2000_Int.J.Dev.Biol_44_689Acetylcholine synthesis and neuron differentiation
Biagioni_2000_Int.J.Dev.Neurosci_18_93Activation of neurospecific gene expression by antennapedia homeobox peptide
Biagioni_2000_J.Neurosci.Res_62_591Modulation of cholinergic marker expression by nerve growth factor in dorsal root ganglia
Biely_2000_Anal.Biochem_286_289A chromogenic substrate for a beta-xylosidase-coupled assay of alpha-glucuronidase
Biely_2000_Biochim.Biophys.Acta_1474_360Inverting character of alpha-glucuronidase A from Aspergillus tubingensis
Bigbee_2000_Brain.Res_861_354Evidence for the direct role of acetylcholinesterase in neurite outgrowth in primary dorsal root ganglion neurons
Birks_2000_Cochrane.Database.Syst.Rev__CD001190Donepezil for mild and moderate Alzheimer's disease
Birks_2000_Cochrane.Database.Syst.Rev__CD001191Rivastigmine for Alzheimer's disease
Bitner_2000_Brain.Res_871_66Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat
Blader_2000_Hum.Mol.Genet_9_945Zebrafish developmental genetics and central nervous system development
Blake_2000_Trends.Neurosci_23_92The neurobiology of duchenne muscular dystrophy: learning lessons from muscle?
Blasina_2000_Cell.Tissue.Res_299_173Evidence for a noncholinergic function of acetylcholinesterase during development of chicken retina as shown by fasciculin
Blass_2000_Alzheimer.Dis.Assoc.Disord_14_39Randomized, double-blind, placebo-controlled, multicenter study to evaluate the safety and tolerability of metrifonate in patients with probable Alzheimer disease. The Metrifonate Study Group
Blomquist_2000_Biochem.J_352 Pt 2_319Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor
Blum_2000_J.Bacteriol_182_1346Feruloyl esterase activity of the Clostridium thermocellum cellulosome can be attributed to previously unknown domains of XynY and XynZ
Boccia_2000_Neurobiol.Learn.Mem_74_217Involvement of central cholinergic mechanisms in the effects of oxytocin and an oxytocin receptor antagonist on retention performance in mice
Boger_2000_Proc.Natl.Acad.Sci.U.S.A_97_5044Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide
Bompard-Gilles_2000_Structure.Fold.Des_8_153A new variant of the Ntn hydrolase fold revealed by the crystal structure of L-aminopeptidase D-Ala-esterase/amidase from Ochrobactrum anthropi
Bomser_2000_J.Biochem.Mol.Toxicol_14_346Activation of extracellular signal-regulated kinases (ERK 44/42) by chlorpyrifos oxon in Chinese hamster ovary cells
Boney_2000_Mol.Endocrinol_14_805The critical role of Shc in insulin-like growth factor-I-mediated mitogenesis and differentiation in 3T3-L1 preadipocytes
Boogaard_2000_Xenobiotica_30_485Metabolic inactivation of five glycidyl ethers in lung and liver of humans, rats and mice in vitro
Boorman_2000_J.Physiol_529 Pt 3_565Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes
Borgaonkar_2000_Dig.Dis.Sci_45_1644Acute on chronic intestinal pseudoobstruction responds to neostigmine
Born_2000_Biochemistry_39_8556Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Haemophilus influenzae met2-encoded homoserine transacetylase
Bornemann_2000_Ann.N.Y.Acad.Sci_908_260Transgenic mouse models of Alzheimer's disease
Bosch_2000_Gene_245_65Complete nucleotide sequence and evolutionary significance of a chromosomally encoded naphthalene-degradation lower pathway from Pseudomonas stutzeri AN10
Botero Cid_2000_J.Med.Chem_43_2155Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically
Boucher_2000_Gene_247_145Structure, mapping and expression of the human gene encoding the homeodomain protein, SIX2
Boudreau-Lariviere_2000_Am.J.Physiol.Regul.Integr.Comp.Physiol_278_R140Myotubes originating from single fast and slow satellite cells display similar patterns of AChE expression
Boudreau-Lariviere_2000_J.Neurochem_74_2250Molecular mechanisms underlying the activity-linked alterations in acetylcholinesterase mRNAs in developing versus adult rat skeletal muscles
Bourne_2000_Structure.Fold.Des_8_143The atomic-resolution structure of a novel bacterial esterase
Bouzat_2000_J.Gen.Physiol_115_663Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics
Bowman_2000_Microbes.Infect_2_1479Assessing the impact of Plasmodium falciparum genome sequencing
Boyd_2000_Bioorg.Med.Chem.Lett_10_3952-(Alkylthio)pyrimidin-4-ones as novel, reversible inhibitors of lipoprotein-associated phospholipase A2
Boyd_2000_J.Biol.Chem_275_22401Probing the active center Gorge of acetylcholinesterase by fluorophores Linked to substituted cysteines
Boyle_2000_Bioorg.Med.Chem.Lett_10_2727Benzylidene ketal derivatives as M2 muscarinic receptor antagonists
Boyle_2000_Chem.Biol.Interact_125_209Gender-specific metabolism of benz[a]anthracene in hepatic microsomes from Long-Evans and Hooded Lister rats
Bradamante_2000_Coll.Antropol_24_373Plasma cholinesterase activity in patients with uterine cervical cancer during radiotherapy
Braginskaia_2000_Zh.Nevrol.Psikhiatr.Im.S.S.Korsakova_100_29[Certain biochemical blood markers in the process of cholinergic therapy in Alzheimer's disease]
Braida_2000_Neuroreport_11_2025Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats
Braida_2000_Pharmacol.Res_41_671Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit
Braida_2000_Pharmacol.Res_42_299Eptastigmine improves eight-arm radial maze performance in aged rats
Braida_2000_Pharmacol.Res_42_495Eptastigmine restores the aged rat's normal cortical spectral power pattern
Bramich_2000_Auton.Neurosci_82_109Potentiation by neostigmine of responses to vagal nerve stimulation in the sinus venosus of the toad
Brand_2000_J.Neurochem_74_1596N-methyl bases of ethanolamine prevent apoptotic cell death induced by oxidative stress in cells of oligodendroglia origin
Brandt_2000_Adv.Exp.Med.Biol_477_97Development of a tertiary-structure model of the C-terminal domain of DPP IV
Braselton_2000_J.Vet.Diagn.Invest_12_15Gas chromatography/mass spectrometry identification and quantification of isazophos in a famphur pour-on and in bovine tissues after a toxic exposure
Braun_2000_Biochimie_82_705Myristoylation-dependent N-terminal cleavage of the myristoylated alanine-rich C kinase substrate (MARCKS) by cellular extracts
Brautaset_2000_Chem.Biol_7_395Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway
Bray_2000_Protein.Eng_13_153The CATH Dictionary of Homologous Superfamilies (DHS): a consensus approach for identifying distant structural homologues
Breese_2000_Neuropsychopharmacology_23_351Abnormal regulation of high affinity nicotinic receptors in subjects with schizophrenia
Breeze_2000_Neuropharmacol_39_2706Optical measurements of presynaptic nicotinic effects
Breithaupt_2000_Z.Naturforsch.C.J.Biosci_55_971Enzymatic hydrolysis of carotenoid fatty acid esters of red pepper (Capsicum annuum L.) by a lipase from Candida rugosa
Bren_2000_J.Biol.Chem_275_12692Hydrophobic pairwise interactions stabilize alpha-conotoxin MI in the muscle acetylcholine receptor binding site
Bresler_2000_Appl.Environ.Microbiol_66_904Gene cloning and nucleotide sequencing and properties of a cocaine esterase from Rhodococcus sp. strain MB1
Bretaud_2000_Ecotoxicol.Environ.Saf_47_117Effects of carbofuran, diuron, and nicosulfuron on acetylcholinesterase activity in goldfish (Carassius auratus)
Briguet_2000_J.Neurosci_20_5989The Ets transcription factor GABP is required for postsynaptic differentiation in vivo
Britt_2000_Comp.Med_50_133Histopathologic changes in the brain, heart, and skeletal muscle of rhesus macaques, ten days after exposure to soman (an organophosphorus nerve agent)
Broberger_2000_Brain.Res.Mol.Brain.Res_75_25Differential effects of intrastriatally infused fully and endcap phosphorothioate antisense oligonucleotides on morphology, histochemistry and prodynorphin expression in rat brain
Brocca_2000_Protein.Sci_9_985Mutants provide evidence of the importance of glycosydic chains in the activation of lipase 1 from Candida rugosa
Brody_2000_J.Cell.Biol_150_F83Drosophila melanogaster G protein-coupled receptors
Bronfman_2000_Neurobiol.Dis_7_152Acetylcholinesterase-positive fiber deafferentation and cell shrinkage in the septohippocampal pathway of aged amyloid precursor protein london mutant transgenic mice
Bronfman_2000_Neurosci_97_411No evidence for cholinergic problems in apolipoprotein E knockout and apolipoprotein E4 transgenic mice
Brophy_2000_Pharmacogenet_10_453Analysis of paraoxonase (PON1) L55M status requires both genotype and phenotype
Brown_2000_Enzyme.Microb.Technol_26_801Accelerated prediction of recombinant protein production in Saccharomyces cerevisiae by using rapid monitoring techniques
Brown_2000_Handb.Exp.Pharmacol_144_3The History of the Neuronal Nicotinic Receptors
Bruneau_2000_J.Histochem.Cytochem_48_267The affinity binding sites of pancreatic bile salt-dependent lipase in pancreatic and intestinal tissues
Brunner_2000_Chromosome.Res_8_465Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis
Brzozowski_2000_Biochemistry_39_15071Structural origins of the interfacial activation in Thermomyces (Humicola) lanuginosa lipase
Buccafusco_2000_Brain.Res_852_76Prevention of precipitated withdrawal symptoms by activating central cholinergic systems during a dependence-producing schedule of morphine in rats
Budd_2000_J.Biol.Chem_275_19667Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha
Budiman_2000_Genome.Res_10_129A deep-coverage tomato BAC library and prospects toward development of an STC framework for genome sequencing
Buhler_2000_Chemistry_6_2564A convenient synthesis of optically active 5,5-disubstituted 4-amino- and 4-hydroxy-2(5H)-furanones from (S)-ketone cyanohydrins
Buisson_2000_Handb.Exp.Pharmacol_144_271Neuronal Nicotinic Acetylcholine Receptors: From Biophysical Properties to Human Diseases
Buisson_2000_Neuropharmacol_39_2561The unusual nature of epibatidine responses at the alpha4beta2 nicotinic acetylcholine receptor
Bunc_2000_Pflugers.Arch_440_R173In vivo effects of head-to-tail 3-alkylpiridinium polymers isolated from the marine sponge Raniera sarai
Bunnemann_2000_Eur.J.Pharmacol_393_249Chronic nicotine treatment decreases neurofilament immunoreactivity in the rat ventral tegmental area
Burgen_2000_Annu.Rev.Pharmacol.Toxicol_40_1Targets of drug action
Burkey_2000_Mutat.Res_453_25Cytotoxicity and genotoxicity of methyleugenol and related congeners-- a mechanism of activation for methyleugenol
Burruel_2000_Toxicol.Appl.Pharmacol_165_148Paternal effects from methamidophos administration in mice
Burt_2000_Curr.Psychiatry.Rep_2_473Donepezil and related cholinesterase inhibitors as mood and behavioral controlling agents
Buschges_2000_J.Neurophysiol_84_2758Roles of high-voltage-activated calcium channel subtypes in a vertebrate spinal locomotor network
Busetto_2000_J.Neurosci_20_685Hebbian mechanisms revealed by electrical stimulation at developing rat neuromuscular junctions
Buttarelli_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_125_225Acetylcholine/dopamine interaction in planaria
Buznikov_2000_Neurosci.Behav.Physiol_30_53Cholinoreceptors of early (preneural) sea urchin embryos
Byrne_2000_Pest.Manag.Sci_56_867The role of B-type esterases in conferring insecticide resistance in the tobacco whitefly, Bemisia tabaci (Genn)
Byth_2000_Perception_29_461Cholinergic agents and the McCollough effect
Cacabelos_2000_Drugs.Today.(Barc)_36_415Pharmacological treatment of Alzheimer disease: from psychotropic drugs and cholinesterase inhibitors to pharmacogenomics
Cadenhead_2000_Am.J.Psychiatry_157_55Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder
Cadoni_2000_Eur.J.Pharmacol_387_R23Differential changes in accumbens shell and core dopamine in behavioral sensitization to nicotine
Caillol_2000_J.Cell.Biochem_79_628Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells
Cajal_2000_Biochemistry_39_413Interfacial control of lid opening in Thermomyces lanuginosa lipase
Cajal_2000_Biochimie_82_1053Effect of the lipid interface on the catalytic activity and spectroscopic properties of a fungal lipase
Cajaraville_2000_Sci.Total.Environ_247_295The use of biomarkers to assess the impact of pollution in coastal environments of the Iberian Peninsula: a practical approach
Caldas_2000_Rev.Saude.Publica_34_529[Assessment of the chronic risk for ingestion of pesticide residues in the Brazilian diet]
Cameron_2000_Spine.(Phila.Pa.1976)_25_1917A prospective study of serum pseudocholinesterase levels in patients with chronic spinal pain: a preliminary study
Camps_2000_J.Med.Chem_43_4657New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease
Camps_2000_Mol.Pharmacol_57_409Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer's Disease
Cantallops_2000_Curr.Biol_10_R620Synapse formation: if it looks like a duck and quacks like a duck
Cape_2000_Eur.J.Neurosci_12_2166Effects of glutamate agonist versus procaine microinjections into the basal forebrain cholinergic cell area upon gamma and theta EEG activity and sleep-wake state
Cape_2000_J.Neurosci_20_8452Neurotensin-induced bursting of cholinergic basal forebrain neurons promotes gamma and theta cortical activity together with waking and paradoxical sleep
Carbonell_2000_Mol.Divers_5_131Identification of selective inhibitors of acetylcholinesterase from a combinatorial library of 2,5-piperazinediones
Carboni_2000_Drug.Alcohol.Depend_58_93Dissociation of physical abstinence signs from changes in extracellular dopamine in the nucleus accumbens and in the prefrontal cortex of nicotine dependent rats
Carboni_2000_J.Neurosci_20_RC102Stimulation of in vivo dopamine transmission in the bed nucleus of stria terminalis by reinforcing drugs
Carcenac_2000_Presse.Med_29_992[Extra-pyramidal syndrome induced by donepezil]
Carlier_2000_Angew.Chem.Int.Ed.Engl_39_1775Dimerization of an Inactive Fragment of Huperzine A Produces a Drug with Twice the Potency of the Natural Product
Carlson_2000_J.Toxicol.Environ.Health.A_61_709Metabolism of styrene oxide to styrene glycol in enriched mouse clara-cell preparations
Carlson_2000_Pharmacol.Biochem.Behav_65_683Effects of H1 antagonists on cholinomimetic-induced tremulous jaw movements: studies of diphenhydramine, doxepin, and mepyramine
Carmona_2000_Drug.Metab.Dispos_28_367Butyrylcholinesterase accelerates cocaine metabolism: in vitro and in vivo effects in nonhuman primates and humans
Carninci_2000_Genome.Res_10_1617Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes
Caron_2000_Life.Sci_67_447Effects of ethanol on phosphoinositide hydrolysis and muscarinic acetylcholine receptor number in SH-SY5Y cells
Carpentier_2000_Neurotoxicol_21_521Effects of atropine sulphate on seizure activity and brain damage produced by soman in guinea-pigs: ECoG correlates of neuropathology
Carriere_2000_Gastroenterology_119_949The specific activities of human digestive lipases measured from the in vivo and in vitro lipolysis of test meals
Carroll_2000_Tuber.Lung.Dis_80_117Identification of Mycobacterium avium DNA sequences that encode exported proteins by using phoA gene fusions
Carsi_2000_Toxicon_38_187m1-toxin isotoxins from the green mamba (Dendroaspis angusticeps) that selectively block m1 muscarinic receptors
Cartaud_2000_Microsc.Res.Tech_49_73The torpedo electrocyte: a model system to study membrane-cytoskeleton interactions at the postsynaptic membrane
Carter_2000_Food.Addit.Contam_17_503Investigations into the causes of residue variability on carrots in the UK
Carvalho_2000_J.Biotechnol_81_1Kinetics of cutinase catalyzed transesterification in AOT reversed micelles: modeling of a batch stirred tank reactor
Cashman_2000_J.Pharmacol.Exp.Ther_293_952Catalytic antibodies that hydrolyze (-)-cocaine obtained by a high-throughput procedure
Cassell_2000_Neurosci_95_489Glycine receptor (gephyrin) immunoreactivity is present on cholinergic neurons in the dorsal vagal complex
Castanon_2000_An.Esp.Pediatr_53_53[Datura stramonium poisoning]
Cavalier_2000_Acc.Chem.Res_33_579Covalent inhibition of digestive lipases by chiral phosphonates
Cavallotti_2000_Ann.Anat_182_243Acetylcholinesterase activity in rat thymus after immunostimulation with interleukin beta
Cavallotti_2000_Neurochem.Int_36_75Quantification of acetylcholinesterase-positive structures in human thymus during development and aging
Chahinian_2000_Biosci.Biotechnol.Biochem_64_215Production of extracellular lipases by Penicillium cyclopium purification and characterization of a partial acylglycerol lipase
Chahinian_2000_Curr.Protein.Pept.Sci_1_91The C-terminal domain of pancreatic lipase: functional and structural analogies with c2 domains
Chahinian_2000_Lipids_35_919Kinetic properties of Penicillium cyclopium lipases studied with vinyl esters
Chamaon_2000_FEBS.Lett_482_189Neuronal nicotinic acetylcholine receptors of Drosophila melanogaster: the alpha-subunit dalpha3 and the beta-type subunit ARD co-assemble within the same receptor complex
Chan_2000_Toxicol.Appl.Pharmacol_167_231Lidocaine-induced alterations in agonist-induced ion transport of cultured swine tracheal submucosal gland cells
Chanas-Sacre_2000_Dev.Dyn_219_514A 295-kDA intermediate filament-associated protein in radial glia and developing muscle cells in vivo and in vitro
Chandler_2000_Neuromuscul.Disord_10_584Hereditary motor and sensory neuropathy--Lom (HMSNL): refined genetic mapping in Romani (Gypsy) families from several European countries
Chaney_2000_Toxicol.Appl.Pharmacol_165_107Acute effects of an insect repellent, N,N-diethyl-m-toluamide, on cholinesterase inhibition induced by pyridostigmine bromide in rats
Chapman_2000_Neurosci_97_419Reversal of presynaptic deficits of apolipoprotein E-deficient mice in human apolipoprotein E transgenic mice
Charpentier_2000_Anal.Biochem_285_76A method to estimate acetylcholinesterase-active sites and turnover in insects
Chassany_2000_Drug.Saf_22_53Drug-induced diarrhoea
Cheeta_2000_Eur.J.Neurosci_12_3797The role of 5-HT1A receptors in mediating the anxiogenic effects of nicotine following lateral septal administration
Cheeta_2000_Prog.Neuropsychopharmacol.Biol.Psychiatry_24_1053Hippocampal and septal injections of nicotine and 8-OH-DPAT distinguish among different animal tests of anxiety
Chen_2000_Comp.Biochem.Physiol.B.Biochem.Mol.Biol_127_97Muscle regulatory factor gene: zebrafish (Danio rerio) myogenin cDNA
Chen_2000_Drug.Dev.Ind.Pharm_26_1007Anaerobic stability of aqueous physostigmine solution
Chen_2000_Nature_408_936Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen_2000_Sheng.Li.Xue.Bao_52_295[Protective effect of exogenous glial cell line derived neurotrophic factor on neurons after sciatic nerve injury in rats]
Chen_2000_Virus.Res_66_155Analysis of host response modifier ORFs of ectromelia virus, the causative agent of mousepox
Chen_2000_Zhongguo.Xiu.Fu.Chong.Jian.Wai.Ke.Za.Zhi_14_343[Protective effect of tumor necrosis factor-alpha on motor neurons after peripheral nerve injury]
Cheng_2000_J.Bacteriol_182_4744Genetic analysis of a gene cluster for cyclohexanol oxidation in Acinetobacter sp. Strain SE19 by in vitro transposition
Chentanez_2000_J.Med.Assoc.Thai_83_1101Modification of the acetylcholinesterase (AchE) staining method in Hirschsprung's disease
Chentanez_2000_J.Med.Assoc.Thai_83_1196New classification of histochemical staining patterns of acetylcholinesterase activity in rectal suction biopsy in Hirschsprung's disease
Chevalier_2000_J.Comp.Neurol_419_137Honeycomb-like structure of the intermediate layers of the rat superior colliculus, with additional observations in several other mammals: AChE patterning
Chiappe_2000_Chem.Res.Toxicol_13_831Stereochemical course of the biotransformation of isoprene monoepoxides and of the corresponding diols with liver microsomes from control and induced rats
Chijiiwa_2000_Am.J.Surg_179_161Biliary indocyanine green excretion as a predictor of hepatic adenosine triphosphate levels in patients with obstructive jaundice
Chiodera_2000_J.Investig.Med_48_203Effect of aging on the arginine-vasopressin response to physostigmine and angiotensin II in normal men
Chiravuri_2000_J.Immunol_165_5695Vesicular localization and characterization of a novel post-proline-cleaving aminodipeptidase, quiescent cell proline dipeptidase.
Cho_2000_FEMS.Microbiol.Lett_186_235Cloning, sequencing and expression in Escherichia coli of a thermophilic lipase from Bacillus thermoleovorans ID-1
Cho_2000_J.Biol.Chem_275_19942Phosphorylation of the rat vesicular acetylcholine transporter
Cho_2000_Toxicology_146_111Enhanced expression of rat hepatic microsomal epoxide hydrolase by methylthiazole in conjunction with liver injury
Choe_2000_Nucl.Med.Biol_27_263Syntheses and biological evaluation of (18)F-labeled 3-(1-benzyl-piperidin-4-yl)-1-(1-methyl-1H-indol-3-yl)propan-1-ones for in vivo mapping of acetylcholinesterase
Choi_2000_Appl.Microbiol.Biotechnol_54_641Continuous production of enantiopure 1,2-epoxyhexane by yeast epoxide hydrolase in a two-phase membrane bioreactor
Chou_2000_Brain.Res.Mol.Brain.Res_77_232Wnt-1 inhibits nerve growth factor-induced differentiation of PC12 cells by preventing the induction of some but not all late-response genes
Christopoulos_2000_J.Pharmacol.Toxicol.Methods_43_55Transducer abstraction: a novel approach to the detection of partial agonist efficacy in radioligand binding studies
Christov_2000_J.Biotechnol_83_231Effects of purified endo-beta-1,4-xylanases of family 10 and 11 and acetyl xylan esterases on eucalypt sulfite dissolving pulp
Chu_2000_Brain.Res_887_399Nicotinic acetylcholine receptor-mediated synaptic potentials in rat neocortex
Chuang_2000_Chang.Gung.Med.J_23_80Experience in the treatment of myasthenia gravis with double filtration plasmapheresis
Chuiko_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_127_233Comparative study of acetylcholinesterase and butyrylcholinesterase in brain and serum of several freshwater fish: specific activities and in vitro inhibition by DDVP, an organophosphorus pesticide
Cicardi_2000_J.Viral.Hepat_7_138Prevalence and risk factors for the presence of serum cryoglobulins in patients with chronic hepatitis C
Ciruela_2000_Mol.Cell.Neurosci_15_36Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1alpha: evidence for an anchoring function
Clair_2000_Eur.J.Pharm.Sci_9_259Stability study of a new antidote drug combination (Atropine-HI-6-Prodiazepam) for treatment of organophosphate poisoning
Clapper_2000_Curr.Oncol.Rep_2_251Genetic polymorphism and cancer risk
Clark_2000_Brain.Behav.Evol_56_235Mammal-like striatal functions in Anolis. I. Distribution of serotonin receptor subtypes, and absence of striosome and matrix organization
Claudianos_2000_in.PESTICIDE.RESISTANCEA genomics perspective on mutant aliesterases and metabolic resistance to organophosphates
Clee_2000_J.Lipid.Res_41_521Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis
Clemente_2000_Appl.Microbiol.Biotechnol_53_420Sequence of PHA synthase gene from two strains of Rhodospirillum rubrum and in vivo substrate specificity of four PHA synthases across two heterologous expression systems
Clementi_2000_Eur.J.Pharmacol_393_1Special issue nicotinic neuronal receptors
Clementi_2000_Eur.J.Pharmacol_393_3Neuronal nicotinic receptors, important new players in brain function
Clementi_2000_Handb.Exp.Pharmacol_144_751Involvement of Neuronal Nicotinic Receptors in Disease
Clementi_2000_Trends.Pharmacol.Sci_21_35Neuronal nicotinic acetylcholine receptors: from structure to therapeutics
Cohen_2000_Infect.Immun_68_4549Attenuated nontoxinogenic and nonencapsulated recombinant Bacillus anthracis spore vaccines protect against anthrax
Coiro_2000_J.Investig.Med_48_133Dopaminergic and cholinergic involvement in the inhibitory effect of dexamethasone on the TSH response to TRH
Combes_2000_J.Mol.Biol_300_727Four genes encode acetylcholinesterases in the nematodes Caenorhabditis elegans and Caenorhabditis briggsae. cDNA sequences, genomic structures, mutations and in vivo expression
Conroy_2000_Neuropharmacol_39_2699Cluster formation of alpha7-containing nicotinic receptors at interneuronal interfaces in cell culture
Conti-Fine_2000_Eur.J.Pharmacol_393_279Neuronal nicotinic receptors in non-neuronal cells: new mediators of tobacco toxicity?
Cook_2000_Aliment.Pharmacol.Ther_14_1287Abnormal contractile properties of rectal smooth muscle in chronic ulcerative colitis
Cooper_2000_J.Neuroophthalmol_20_5Accommodative and vergence findings in ocular myasthenia: a case analysis
Copping_2000_Pest.Manag.Sci_56_651Biopesticides: a review of their action, applications and efficacy
Cordeiro_2000_Neurosci.Res_38_385Ca(2+) regulation of the carrier-mediated gamma-aminobutyric acid release from isolated synaptic plasma membrane vesicles
Cornell_2000_Development_127_2873Delta signaling mediates segregation of neural crest and spinal sensory neurons from zebrafish lateral neural plate
Coronas_2000_Neurosci_98_213Acetylcholine induces neuritic outgrowth in rat primary olfactory bulb cultures
Corrigall_2000_Psychopharmacology.(Berl)_149_107Response of nicotine self-administration in the rat to manipulations of mu-opioid and gamma-aminobutyric acid receptors in the ventral tegmental area
Costa_2000_Bioseparation_9_231Scale-up of recombinant cutinase recovery by whole broth extraction with PEG-phosphate aqueous two-phase
Costello_2000_Histol.Histopathol_15_861Eosinophils and airway nerves in asthma
Cote_2000_Microbiology_146 ( Pt 7)_1555A novel beta-glucoside-specific PTS locus from Streptococcus mutans that is not inhibited by glucose
Cotman_2000_Mol.Cell.Neurosci_15_183Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain
Cottrell_2000_Biochemistry_39_15129Identification of critical residues in the active site of porcine membrane-bound aminopeptidase P
Coulson_2000_Neurochem.Int_36_175What the evolution of the amyloid protein precursor supergene family tells us about its function
Couture_2000_Arterioscler.Thromb.Vasc.Biol_20_815Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles: The Framingham Offspring Study
Cowles_2000_J.Bacteriol_182_6339BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
Crapo_2000_Am.J.Respir.Crit.Care.Med_161_309Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999
Creason_2000_J.Neurochem_74_882Isolation and functional characterization of the chick M5 muscarinic acetylcholine receptor gene
Crumpton_2000_Brain.Res.Dev.Brain.Res_121_189Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?
Crumpton_2000_Brain.Res_857_87Developmental neurotoxicity of chlorpyrifos in vivo and in vitro: effects on nuclear transcription factors involved in cell replication and differentiation
Csanady_2000_Toxicol.Appl.Pharmacol_165_1A physiological toxicokinetic model for exogenous and endogenous ethylene and ethylene oxide in rat, mouse, and human: formation of 2-hydroxyethyl adducts with hemoglobin and DNA
Csillik_2000_Neurotoxicol_21_343Effect of the pesticide Deltamethrin on the Mauthner cells of Lake Balaton fish
Cuajungco_2000_Ann.N.Y.Acad.Sci_920_292Metal chelation as a potential therapy for Alzheimer's disease
Cuevas_2000_Chemistry_6_3228Toward an artifical acetylcholinesterase
Cuevas_2000_J.Physiol_525 Pt 3_735Two distinct classes of functional 7-containing nicotinic receptor on rat superior cervical ganglion neurons
Culetto_2000_Hum.Mol.Genet_9_869A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes
Cummings_2000_Am.J.Geriatr.Psychiatry_8_134The relationship between donepezil and behavioral disturbances in patients with Alzheimer's disease
Cummings_2000_Am.J.Psychiatry_157_4Cholinesterase inhibitors: A new class of psychotropic compounds
Cummings_2000_Lancet_356_2024Cholinesterase inhibitors: expanding applications
Cunha_2000_Bioseparation_9_203Effect of salts and surfactants on the partitioning of Fusarium solani pisi cutinase in aqueous two-phase systems of thermoseparating ethylene oxide/propylene oxide random copolymer and hydroxypropyl starch
Curtis_2000_Eur.J.Pharmacol_393_155A new look at the neuronal nicotinic acetylcholine receptor pharmacophore
Cusson_2000_Gen.Comp.Endocrinol_117_343Functional significance of parasitism-induced suppression of juvenile hormone esterase activity in developmentally delayed Choristoneura fumiferana larvae
D'Agostino_2000_Br.J.Pharmacol_129_493Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype
D'Agostino_2000_Eur.J.Pharmacol_396_29Tachykinin NK(2) receptors facilitate acetylcholine release from guinea-pig isolated trachea
D'Auria_2000_Proteins_40_473The esterase from the thermophilic eubacterium Bacillus acidocaldarius: structural-functional relationship and comparison with the esterase from the hyperthermophilic archaeon Archaeoglobus fulgidus
Dahlqvist_2000_Proc.Natl.Acad.Sci.U.S.A_97_6487Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants
Dai_2000_J.Cell.Biol_150_1321The actin-driven movement and formation of acetylcholine receptor clusters
Dajas-Bailador_2000_Neuropharmacol_39_2799The alpha7 nicotinic acetylcholine receptor subtype mediates nicotine protection against NMDA excitotoxicity in primary hippocampal cultures through a Ca(2+) dependent mechanism
Dallocchio_2000_J.Clin.Psychiatry_61_64Combination of donepezil and gabapentin for behavioral disorders in Alzheimer's disease
Dalmau_2000_Enzyme.Microb.Technol_26_657Effect of different carbon sources on lipase production by Candida rugosa
Daly_2000_Nat.Prod.Rep_17_131Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics
Daly_2000_Proc.Natl.Acad.Sci.U.S.A_97_6120Synaptophysin regulates clathrin-independent endocytosis of synaptic vesicles
Dam_2000_Brain.Res.Dev.Brain.Res_121_179Chlorpyrifos exposure during a critical neonatal period elicits gender-selective deficits in the development of coordination skills and locomotor activity
Damaj_2000_Eur.J.Pharmacol_404_103The involvement of spinal Ca(2+)/calmodulin-protein kinase II in nicotine-induced antinociception in mice
Damaj_2000_Neuropharmacol_39_2785The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model
Damborsky_2000_Folia.Microbiol.(Praha)_45_35Effect of the carbon source on assessment of degrading bacteria with the spread-plating technique during in situ bioremediation
Dandekar_2000_Nucleic.Acids.Res_28_3278Re-annotating the Mycoplasma pneumoniae genome sequence: adding value, function and reading frames
Danet_2000_Biopolymers_57_37Flow analysis for determination of paraoxon with use of immobilized acetylcholinesterase reactor and new type of chemiluminescent reaction
Dani_2000_Epilepsia_41_1063Properties underlying the influence of nicotinic receptors on neuronal excitability and epilepsy
Dani_2000_Eur.J.Pharmacol_393_31Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas
Darroch_2000_Eur.J.Pharmacol_402_161Characterisation of muscarinic receptor subtypes in avian smooth muscle
Dart_2000_Ann.Emerg.Med_36_126Combined evidence-based literature analysis and consensus guidelines for stocking of emergency antidotes in the United States
Das_2000_J.Assoc.Physicians.India_48_540Encephalopathy, intermediate syndrome and delayed polyneuropathy in acute black Danadar (Phorate 10 CG) poisoning
Das_2000_J.Biol.Chem_275_23847Structural basis for the insensitivity of a serine enzyme (palmitoyl-protein thioesterase) to phenylmethylsulfonyl fluoride
Das_2000_Pharmacol.Res_42_213Immobilization stress-induced changes in brain acetylcholinesterase activity and cognitive function in mice
Das_2000_Toxicol.Lett_114_11Chronic toxic effects of quinalphos on some biochemical parameters in labeo rohita (Ham.)
Daub_2000_Annu.Rev.Phytopathol_38_461The Photoactivated Cercospora Toxin Cercosporin: Contributions to Plant Disease and Fundamental Biology
Dave_2000_Z.Naturforsch.C_55_100Tissue cholinesterases. A comparative study of their kinetic properties
Davitt_2000_J.Pediatr.Ophthalmol.Strabismus_37_5Childhood myasthenia
Dawson_2000_Rheumatology.(Oxford)_39_1226An investigation of interactions between the immune system and stimulus-secretion coupling in mouse submandibular acinar cells. A possible mechanism to account for reduced salivary flow rates associated with the onset of Sjogren's syndrome
De Amici_2000_Farmaco_55_535Synthesis and pharmacological characterization of new chiral derivatives of muscarine and allo-muscarine
De Berardinis_2000_Mol.Pharmacol_58_542Human microsomal epoxide hydrolase is the target of germander-induced autoantibodies on the surface of human hepatocytes
De Biasi_2000_Eur.J.Pharmacol_393_137Nicotinic acetylcholine receptors in the autonomic control of bladder function
De Gois_2000_J.Biol.Chem_275_36683Is RE1/NRSE a common cis-regulatory sequence for ChAT and VAChT genes?
De Jaco_2000_J.Neurochem_75_1123Modulation of acetylcholinesterase and voltage-gated Na(+) channels in choline acetyltransferase- transfected neuroblastoma clones
De Simone_2000_J.Mol.Biol_303_761A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase
De Vos_2000_Nucl.Med.Biol_27_745Pharmacological evaluation of [11C]donepezil as a tracer for visualization of acetylcholinesterase by PET
De Voss_2000_Proc.Natl.Acad.Sci.U.S.A_97_1252The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages
DeLucchi_2000_Int.Tinnitus.J_6_37Transtympanic pilocarpine in tinnitus
Dean_2000_Mayo.Clin.Proc_75_872Physostigmine treatment of gamma-hydroxybutyric acid overdose: appropriate or inappropriate use of a reversal agent?
Deeb_2000_J.Lipid.Res_41_155The C-514T polymorphism in the human hepatic lipase gene promoter diminishes its activity
Degrassi_2000_Microbiology_146 ( Pt 7)_1585The acetyl xylan esterase of Bacillus pumilus belongs to a family of esterases with broad substrate specificity
Degroot_2000_Learn.Mem_7_293Increasing acetylcholine levels in the hippocampus or entorhinal cortex reverses the impairing effects of septal GABA receptor activation on spontaneous alternation
Deleu_2000_Arch.Neurol_57_1380Donepezil in the treatment of Alzheimer disease
Delfini_2000_J.Magn.Reson_144_1291H NMR relaxation investigation of inhibitors interacting with Torpedo californica acetylcholinesterase
Dembele_2000_Ecotoxicol.Environ.Saf_45_49Concentration effects of selected insecticides on brain acetylcholinesterase in the common carp (Cyprinus carpio L.)
Deneris_2000_Eur.J.Pharmacol_393_69Transcriptional control of the neuronal nicotinic acetylcholine receptor gene cluster by the beta43' enhancer, Sp1, SCIP and ETS transcription factors
Deneris_2000_Handb.Exp.Pharmacol_144_57Transcriptional Regulation of Neuronal nAChR Subunit Genes
Deprez_2000_Biochem.J_350 Pt 1_283Interaction of the collagen-like tail of asymmetric acetylcholinesterase with heparin depends on triple-helical conformation, sequence and stability
Deprez_2000_Protein.Eng_13_27Molecular modeling of the collagen-like tail of asymmetric acetylcholinesterase
Despres_2000_Arterioscler.Thromb.Vasc.Biol_20_1932Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study
Dessen_2000_Biochim.Biophys.Acta_1488_40Structure and mechanism of human cytosolic phospholipase A(2)
Devedjiev_2000_Structure_8_1137Crystal structure of the human acyl protein thioesterase I from a single X-ray data set to 1.5 A
Devlin_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_125_53Pharmacological identification of acetylcholine receptor subtypes in echinoderm smooth muscle (Sclerodactyla briareus)
Di Angelantonio_2000_Br.J.Pharmacol_129_1771Antagonism of nicotinic receptors of rat chromaffin cells by N,N, N-trimethyl-1-(4-trans-stilbenoxy)-2-propylammonium iodide: a patch clamp and ligand binding study
Di Chiara_2000_Eur.J.Pharmacol_393_295Role of dopamine in the behavioural actions of nicotine related to addiction
Di Chiara_2000_Handb.Exp.Pharmacol_144_603Behavioural Pharmacology and Neurobiology of Nicotine Reward and Dependence
Diamantino_2000_Ecotoxicol.Environ.Saf_45_253Toxicity of Sodium Molybdate and Sodium Dichromate to Daphnia magna Straus Evaluated in Acute, Chronic, and Acetylcholinesterase Inhibition Tests
Diaz_2000_Ann.N.Y.Acad.Sci_916_628Insecticide resistance studies on Blattella germanica (Dictyoptera:Blattellidae) from Cuba
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Diez_2000_Clin.Endocrinol.(Oxf)_53_587Cholinergic modulation of growth hormone responses to growth hormone-releasing hormone in uraemic patients on peritoneal dialysis
Diez_2000_Neurosci_100_259Neuropeptides in hippocampus and cortex in transgenic mice overexpressing V717F beta-amyloid precursor protein--initial observations
Dileep_2000_Indian.J.Exp.Biol_38_1245Influence of metham sodium on suppression of collar rot disease of peanut, in vitro antibiosis, siderophore production and root colonization by a fluorescent pseudomonad strain FPO4
Dineley_2000_J.Biol.Chem_275_13974Amino acid determinants of alpha 7 nicotinic acetylcholine receptor surface expression
Ding_2000_Genes.Cells_5_169Large-scale screening of intracellular protein localization in living fission yeast cells by the use of a GFP-fusion genomic DNA library.
Ding_2000_J.Neurochem_74_1514Dopamine receptor-mediated regulation of striatal cholinergic activity: positron emission tomography studies with norchloro[18F]fluoroepibatidine
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Dominguez_2000_FEBS.Lett_482_109Interactions of bile salt micelles and colipase studied through intermolecular nOes
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Donaghy_2000_J.Appl.Microbiol_88_458Purification and characterization of an extracellular feruloyl esterase from the thermophilic anaerobe Clostridium stercorarium
Donny_2000_Eur.J.Pharmacol_402_231Differential effects of response-contingent and response-independent nicotine in rats
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Doss-Pepe_2000_Biochemistry_39_14884Interaction of collagen-like peptide models of asymmetric acetylcholinesterase with glycosaminoglycans: spectroscopic studies of conformational changes and stability
Drake_2000_Lab.Invest_80_1491Structural and functional denervation of human detrusor after spinal cord injury
Draper_2000_Arch.Biochem.Biophys_376_199Identification of CYP2C9 as a human liver microsomal linoleic acid epoxygenase
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Dringenberg_2000_Neurobiol.Aging_21_135Effect of tacrine on EEG slowing in the rat: enhancement by concurrent monoamine therapy
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Drisdel_2000_J.Neurosci_20_133Neuronal alpha-bungarotoxin receptors are alpha7 subunit homomers
Dronfield_2000_J.Psychopharmacol_14_275Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat
Drouault_2000_Appl.Environ.Microbiol_66_588Expression of the Staphylococcus hyicus lipase in Lactococcus lactis
Du_2000_Chem.Biol_7_623The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
Du_2000_FEMS.Microbiol.Lett_189_171An oxidation domain in the BlmIII non-ribosomal peptide synthetase probably catalyzing thiazole formation in the biosynthesis of the anti-tumor drug bleomycin in Streptomyces verticillus ATCC15003
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Dudai_2000_Nature_406_686Neurobiology. The shaky trace
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Duthoit_2000_Endocrinology_141_2518Production of immunoreactive thyroglobulin C-terminal fragments during thyroid hormone synthesis
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Efange_2000_Nucl.Med.Biol_27_749Synthesis and biological characterization of stable and radioiodinated (+/-)-trans-2-hydroxy-3-P[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalen e (3'-IBVM)
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Egmond_2000_Biochimie_82_1015Fusarium solani pisi cutinase
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Ellis_2000_Nucleic.Acids.Res_28_377The University of Minnesota Biocatalysis/Biodegradation database: microorganisms, genomics and prediction
Emilien_2000_Arch.Neurol_57_454Prospects for pharmacological intervention in Alzheimer disease
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Erickson_2000_FASEB.J_14_2450Molecular analysis of vesicular amine transporter function and targeting to secretory organelles
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Espanol_2000_Pharmacol.Res_42_489Participation of nitric oxide synthase and cyclo-oxygenase in the signal transduction pathway of ileal muscarinic acetylcholine receptors
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Fanucchi_2000_Toxicol.Appl.Pharmacol_168_253Development of phase II xenobiotic metabolizing enzymes in differentiating murine clara cells
Farag_2000_Reprod.Toxicol_14_457Reproductive toxicology of acephate in male mice
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Farlow_2000_Eur.Neurol_44_236A 52-week study of the efficacy of rivastigmine in patients with mild to moderately severe Alzheimer's disease
Farrow_2000_Antimicrob.Agents.Chemother_44_411The macrolide-lincosamide-streptogramin B resistance determinant from Clostridium difficile 630 contains two erm(B) genes
Fatani_2000_Toxicon_38_1787The effects of lignocaine on actions of the venom from the yellow scorpion Leiurus quinquestriatus in vivo and in vitro
Faundez_2000_Mol.Biol.Cell_11_2591The AP-3 complex required for endosomal synaptic vesicle biogenesis is associated with a casein kinase Ialpha-like isoform
Felder_2000_J.Med.Chem_43_4333Therapeutic opportunities for muscarinic receptors in the central nervous system
Felgenhauer_2000_J.Toxicol.Clin.Toxicol_38_803Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss
Fellowes_2000_Parasitol_121 ( Pt 3)_325Classical neurotransmitters in the ovijector of Ascaris suum: localization and modulation of muscle activity
Fergusson_2000_Int.J.Geriatr.Psychiatry_15_280Donepezil for the treatment of psychosis in dementia with Lewy bodies
Fernandez_2000_Appl.Environ.Microbiol_66_1360Cloning, Characterization, Controlled Overexpression, and Inactivation of the Major Tributyrin Esterase Gene of Lactococcus lactis.
Fernandez_2000_Mov.Disord_15_173Donepezil for Huntington's disease
Ferreira_2000_Bioseparation_9_1Anion exchange purification of plasmid DNA using expanded bed adsorption
Ferretti_2000_Bioorg.Med.Chem.Lett_10_2665Chain-lengthened and imidazoline analogues of nicotine
Fett_2000_Lett.Appl.Microbiol_31_25Production of cutinolytic esterase by filamentous bacteria
Fetterer_2000_J.Parasitol_86_1Characterization of acid phosphatase and phosphorylcholine hydrolase in adult Haemonchus contortus
Fetzner_2000_Naturwiss_87_59Enzymes Involved in the Aerobic Bacterial Degradation of N-Heteroaromatic Compounds: Molybdenum Hydroxylases and Ring-Opening 2,4-Dioxygenases
Ffrench-Constant_2000_Appl.Environ.Microbiol_66_3310A genomic sample sequence of the entomopathogenic bacterium Photorhabdus luminescens W14: potential implications for virulence
File_2000_Eur.J.Pharmacol_393_231Neurobiological mechanisms by which nicotine mediates different types of anxiety
File_2000_Pharmacol.Biochem.Behav_66_65The role of the dorsal hippocampal serotonergic and cholinergic systems in the modulation of anxiety
Fillit_2000_Am.J.Manag.Care_6_S1139The pharmacoeconomics of Alzheimer's disease
Fillit_2000_Am.J.Manag.Care_6_S1149Managed care decisions in Alzheimer's disease
Fillit_2000_Manag.Care.Interface_13_51Practice guidelines for the diagnosis and treatment of Alzheimer's disease in a managed care setting: Part II--Pharmacologic therapy. Alzheimer's Disease (AD) Managed Care Advisory Council
Finney_2000_J.Clin.Invest_106_125Albuterol-induced downregulation of Gsalpha accounts for pulmonary beta(2)-adrenoceptor desensitization in vivo
Fischer_2000_FEMS.Microbiol.Lett_190_21Site-directed mutagenesis of potential catalytic residues in 1H-3-hydroxy-4-oxoquinoline 2,4-dioxygenase, and hypothesis on the catalytic mechanism of 2,4-dioxygenolytic ring cleavage
Fisher_2000_Ann.N.Y.Acad.Sci_920_315M1 muscarinic agonists as potential disease-modifying agents in Alzheimer's disease. Rationale and perspectives
Fisher_2000_Jpn.J.Pharmacol_84_101Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists
Fisher_2000_Neuropharmacol_39_2756Nicotinic receptors on hippocampal cultures can increase synaptic glutamate currents while decreasing the NMDA-receptor component
Fitzpatrick_2000_J.Am.Coll.Cardiol_36_179Tilt methodology in reflex syncope: emerging evidence
Fleming_2000_Biochemistry_39_1522Catalytic mechanism of a C-C hydrolase enzyme: evidence for a gem-diol intermediate, not an acyl enzyme
Flora_2000_Cytobios_103_103Alterations in some membrane properties in rat brain following exposure to lead
Flora_2000_Eur.J.Pharmacol_393_85Transcriptional regulation of the human alpha5 nicotinic receptor subunit gene in neuronal and non-neuronal tissues
Fojan_2000_Biochimie_82_1033What distinguishes an esterase from a lipase: a novel structural approach
Forster_2000_Eur.J.Neurosci_12_3596Laterodorsal tegmental stimulation elicits dopamine efflux in the rat nucleus accumbens by activation of acetylcholine and glutamate receptors in the ventral tegmental area
Forstl_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S103Clinical issues in current drug therapy for dementia
Fort_2000_Teratog.Carcinog.Mutagen_20_35Evaluation of the developmental toxicity of thalidomide using frog embryo teratogenesis assay-xenopus (FETAX): biotransformation and detoxification
Fostieri_2000_FEBS.Lett_481_127The conformation of the main immunogenic region on the alpha-subunit of muscle acetylcholine receptor is affected by neighboring receptor subunits
Fotiou_2000_Int.J.Psychophysiol_37_111Changes in pupil reaction to light in Alzheimer's disease patients: a preliminary report
Foy_2000_Psychother.Psychosom_69_59Assessment and treatment of dementia in medical patients
Franceschini_2000_Behav.Brain.Res_113_3Altered baroreflex responses in alpha7 deficient mice
Francis_2000_Handb.Exp.Pharmacol_144_301The Functional Diversity of Nicotinic Receptors in the Nervous System: Perspectives on Receptor Subtypes and Receptor Specialization
Francis_2000_Mol.Pharmacol_58_109Subtype-selective inhibition of neuronal nicotinic acetylcholine receptors by cocaine is determined by the alpha4 and beta4 subunits
Franken_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_361_107Testing the specificity of allosteric modulators of muscarinic receptors in phylogenetically closely related histamine H1-receptors
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Freedman_2000_J.Chem.Neuroanat_20_299The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia
Freeman_2000_Proc.Natl.Acad.Sci.U.S.A_97_13877Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathology
Fremion_2000_Embo.J_19_4463Amalgam is a ligand for the transmembrane receptor neurotactin and is required for neurotactin-mediated cell adhesion and axon fasciculation in Drosophila
Frenkel_2000_J.Neuroimmunol_106_23Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody
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Frenzel_2000_J.Anal.Toxicol_24_365Rapid multimethod for verification and determination of toxic pesticides in whole blood by means of capillary GC-MS
Fretland_2000_Chem.Biol.Interact_129_41Epoxide hydrolases: biochemistry and molecular biology
Fujie_2000_J.Antibiot.(Tokyo)_53_912FR901469, a novel antifungal antibiotic from an unidentified fungus No.11243. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological properties
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Fujii_2000_Can.J.Physiol.Pharmacol_78_392Enhancement of hippocampal cholinergic neurotransmission through 5-HT1A receptor-mediated pathways by repeated lithium treatment in rats
Fujii_2000_Gen.Pharmacol_35_71YM905, a novel M3 antagonist, inhibits Ca2+ signaling and c-fos gene expression mediated via muscarinic receptors in human T cells
Fujii_2000_Jpn.J.Pharmacol_84_124Calcium signaling and c-Fos gene expression via M3 muscarinic acetylcholine receptors in human T- and B-cells
Fujii_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_362_14Ca2+ oscillation and c-fos gene expression induced via muscarinic acetylcholine receptor in human T- and B-cell lines
Fujii_2000_Neurosci.Lett_289_181Effects of physostigmine and calcium on acetylcholine efflux from the hippocampus of freely moving rats as determined by in vivo microdialysis and a radioimmunoassay
Fujimoto_2000_Alcohol.Clin.Exp.Res_24_48SPlasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance
Fujino_2000_Biochim.Biophys.Acta_1478_102Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase
Fujino_2000_J.Biochem.(Tokyo)_127_1087Identification of the cleavage sites of oxidized protein that are susceptible to oxidized protein hydrolase (OPH) in the primary and tertiary structures of the protein
Fujitani_2000_Food.Chem.Toxicol_38_617Subchronic toxicity of chlorpropham (CIPC) in ICR mice
Fukuda_2000_Proc.Natl.Acad.Sci.U.S.A_97_14715Role of the conserved WHXL motif in the C terminus of synaptotagmin in synaptic vesicle docking
Fukuhara_2000_J.Biol.Chem_275_21730Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway
Fulop_2000_EMBO.Rep_1_277Catalysis of serine oligopeptidases is controlled by a gating filter mechanism
Fureder_2000_Cancer.Genet.Cytogenet_121_133Reciprocal translocation (3;5)(q26;q22) and possible BCHE gene involvement in an unusual myelogenous disorder with both myeloproliferative and dysplastic features
Furey_2000_Brain.Res.Bull_51_213Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: a positron emission tomography regional cerebral blood flow study in healthy humans
Furey_2000_Pharmacol.Biochem.Behav_66_475Time course of pharmacodynamic and pharmacokinetic effects of physostigmine assessed by functional brain imaging in humans
Furey_2000_Science_290_2315Cholinergic enhancement and increased selectivity of perceptual processing during working memory
Furlong_2000_Neurotoxicol_21_91Genetic and temporal determinants of pesticide sensitivity: role of paraoxonase (PON1)
Futagawa_2000_Toxicol.Appl.Pharmacol_165_27The role of cholinergic and noncholinergic mechanisms in the cardiorespiratory failure produced by N-methylcarbamate cholinesterase inhibitors in rabbits
Fylkesnes_2000_Tidsskr.Nor.Laegeforen_120_905[Dementia and hypothyroidism]
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Galeotti_2000_Jpn.J.Pharmacol_84_418Role of 5-HT1A receptors in a mouse passive avoidance paradigm
Galindo-Reyes_2000_Chemosphere_40_233Enzymatic and osmoregulative alterations in white shrimp Litopenaeus vannamei exposed to pesticides
Galisteo_2000_J.Pharmacol.Exp.Ther_294_160Hepatotoxicity of tacrine: occurrence of membrane fluidity alterations without involvement of lipid peroxidation
Gallopin_2000_Nature_404_992Identification of sleep-promoting neurons in vitro
Gandhi_2000_Biochem.Soc.Trans_28_977Papaya (Carica papaya) lipase with some distinct acyl and alkyl specificities as compared with microbial lipases
Gandhi_2000_J.Agric.Food.Chem_48_566Specificity of papaya lipase in esterification with respect to the chemical structure of substrates
Gao_2000_J.Agric.Food.Chem_48_4717Comparative toxicity of selected organophosphate insecticides against resistant and susceptible clones of the greenbug, Schizaphis graminum (Homoptera: aphididae)
Garces_2000_J.Neurosci.Res_60_1FGF9: a motoneuron survival factor expressed by medial thoracic and sacral motoneurons
Garcia_2000_Biomarkers_5_274Characterization of cholinesterase from guppy (Poecilia reticulata) muscle and its in vitro inhibition by environmental contaminants
Garenc_2000_Metabolism_49_432Linkage and association studies of the lipoprotein lipase gene with postheparin plasma lipase activities, body fat, and plasma lipid and lipoprotein concentrations: the HERITAGE Family Study
Garner_2000_Curr.Opin.Neurobiol_10_321Molecular determinants of presynaptic active zones
Geen_2000_J.Neurol.Sci_176_37Autoantibodies to acetylcholinesterase revisited
Gelinas_2000_J.Geriatr.Psychiatry.Neurol_13_9Metrifonate enhances the ability of Alzheimer's disease patients to initiate, organize, and execute instrumental and basic activities of daily living
George_2000_J.Pharmacol.Exp.Ther_295_58Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization
Getova_2000_Folia.Med.(Plovdiv)_42_5Effects of the anticholinesterase drug tacrine on the development of PTZ kindling and on learning and memory processes in mice
Ghelardini_2000_Br.J.Pharmacol_129_1633Loss of muscarinic antinociception by antisense inhibition of M(1) receptors
Ghelardini_2000_Fitoterapia_71 Suppl 1_S124Pro-cognitive activity induced in the rat by low doses of R-(+)-hyoscyamine
Ghosh_2000_Physiol.Genomics_2_1Cholesteryl ester hydrolase in human monocyte/macrophage: cloning, sequencing, and expression of full-length cDNA
Giacobini_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S3Cholinesterase inhibitor therapy stabilizes symptoms of Alzheimer disease
Giacobini_2000_Ann.N.Y.Acad.Sci_920_321Cholinesterase inhibitors stabilize Alzheimer's disease
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Giacobini_2000_Neurochem.Res_25_1185Cholinesterase inhibitors stabilize Alzheimer disease
Gimenez-Pardo_2000_Parasite_7_237Detection of acetylcholinesterase activity and gamma-aminobutyric acid binding sites in Dicrocoelium dendriticum
Gimenez-Pardo_2000_Parasite_7_47Presence of cholinesterases in Echinococcus granulosus protoscolices
Giorgetti_2000_Eur.J.Neurosci_12_1941Local GABAergic modulation of acetylcholine release from the cortex of freely moving rats
Giraud_2000_Proc.Natl.Acad.Sci.U.S.A_97_14795Effect of Bradyrhizobium photosynthesis on stem nodulation of Aeschynomene sensitiva
Girbal_2000_Appl.Environ.Microbiol_66_1202Reductive cleavage of demeton-S-methyl by Corynebacterium glutamicum in cometabolism on more readily metabolizable substrates
Girbal_2000_Biodegradation_11_371Growth rate influences reductive biodegradation of the organophosphorus pesticide demeton by Corynebacterium glutamicum
Girod_2000_Neuropharmacol_39_2715Facilitation of glutamatergic neurotransmission by presynaptic nicotinic acetylcholine receptors
Glass_2000_Nature_407_757The complete sequence of the mucosal pathogen Ureaplasma urealyticum
Glatz_2000_J.Chromatogr.A_895_219Determination of haloalkane dehalogenase activity by capillary zone electrophoresis
Glauser_2000_Epilepsia_41 Suppl 8_S16Idiosyncratic reactions: new methods of identifying high-risk patients
Glozman_2000_Biochim.Biophys.Acta_1487_135Docosahexaenoic acid-deficient phosphatidyl serine and high alpha-tocopherol in a fetal mouse brain over-expressing Cu/Zn-superoxide dismutase
Godfraind_2000_J.Cereb.Blood.Flow.Metab_20_145Hypoxia on hippocampal slices from mice deficient in dystrophin (mdx) and isoforms (mdx3cv)
Goding_2000_J.Leukoc.Biol_67_285Ecto-enzymes: physiology meets pathology
Goel_2000_Biol.Trace.Elem.Res_74_171Protective effects of zinc in chlorpyrifos induced hepatotoxicity: a biochemical and trace elemental study
Gogol_2000_Talanta_53_379Amperometric biosensors based on nafion coated screen-printed electrodes for the determination of cholinesterase inhibitors
Golbraikh_2000_Eur.J.Med.Chem_35_123Validation of protein-based alignment in 3D quantitative structure-activity relationships with CoMFA models
Goldblum_2000_J.Ocul.Pharmacol.Ther_16_29Topical rivastigmine, a selective acetylcholinesterase inhibitor, lowers intraocular pressure in rabbits
Goldstein_2000_J.Biol.Chem_275_2554Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform
Gomez_2000_Brain.Res.Bull_52_263The effect of isoflurane on the release of [(3)H]-acetylcholine from rat brain cortical slices
Gomez_2000_J.Neurosci.Res_62_134Muscular dystrophy alters the processing of light acetylcholinesterase but not butyrylcholinesterase forms in liver of Lama2(dy) mice
Gommans_2000_Neuropharmacol_39_2840Antagonism of the discriminative and aversive stimulus properties of nicotine in C57BL/6J mice
Goncalves_2000_Biochim.Biophys.Acta_1480_92Effects of ionic surfactants used in reversed micelles on cutinase activity and stability
Gopal_2000_Biochem.Biophys.Res.Commun_279_516Mutagenesis of organophosphorus hydrolase to enhance hydrolysis of the nerve agent VX
Gordon_2000_Toxicology_146_1Prolonged elevation in blood pressure in the unrestrained rat exposed to chlorpyrifos
Gorini_2000_Neurochem.Res_25_867Effect of in vivo administration of naloxone on ATP-ase's enzyme systems of synaptic plasma membranes from rat cerebral cortex
Gorokhov_2000_Biophys.J_79_2909Heparan sulfate biosynthesis: a theoretical study of the initial sulfation step by N-deacetylase/N-sulfotransferase
Gotti_2000_Behav.Brain.Res_113_183Drugs selective for nicotinic receptor subtypes: a real possibility or a dream?
Gotti_2000_Handb.Exp.Pharmacol_144_359Properties of Heterologously and Lipid Bilayer Reconstituted Nicotinic Acetylcholine Receptors
Gou_2000_Anal.Chem_72_2774In-tube solid-phase microextraction coupled to capillary LC for carbamate analysis in water samples
Grace_2000_Int.J.Geriatr.Psychiatry_15_1028A comparison of sleep profiles in patients with dementia with lewy bodies and Alzheimer's disease
Gralewicz_2000_Acta.Neurobiol.Exp_60_203Hyposensitivity to amphetamine following exposure to chlorphenvinphos--protection by amphetamine preexposure
Grando_2000_Arch.Dermatol_136_1269Nicotine and pemphigus
Grando_2000_Dermatology_201_290Autoimmunity to keratinocyte acetylcholine receptors in pemphigus
Grauer_2000_Toxicol.Appl.Pharmacol_164_301Stress does not enable pyridostigmine to inhibit brain cholinesterase after parenteral administration
Gray_2000_Cell.Transplant_9_153Conditionally immortalized, multipotential and multifunctional neural stem cell lines as an approach to clinical transplantation
Gray_2000_Risk.Anal_20_665Risk/risk trade-offs in pesticide regulation: an exploratory analysis of the public health effects of a ban on organophosphate and carbamate pesticides
Green_2000_Psychopharmacology.(Berl)_152_289Nornicotine pretreatment decreases intravenous nicotine self-administration in rats
Greenberg_2000_Arch.Neurol_57_94Donepezil therapy in clinical practice: a randomized crossover study
Greene_2000_Arch.Biochem.Biophys_376_420Metabolism of monoepoxides of methyl linoleate: bioactivation and detoxification
Greene_2000_Chem.Res.Toxicol_13_217Toxicity of epoxy fatty acids and related compounds to cells expressing human soluble epoxide hydrolase
Greene_2000_J.Clin.Psychopharmacol_20_350A 12-week, open trial of donepezil hydrochloride in patients with multiple sclerosis and associated cognitive impairments
Greig_2000_Acta.Neurol.Scand.Suppl_176_74The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics
Grigoryan_2000_Restor.Neurol.Neurosci_17_1Conditionally immortal neuroepithelial stem cell grafts restore spatial learning in rats with lesions at the source of cholinergic forebrain projections cholinergic forebrain projections Conditionally immortal neuroepithelial stem cell grafts restore spatial leaming in rats with lesions at the source of cholinergic forebrain projections
Groenewold_2000_J.Am.Soc.Mass.Spectrom_11_69Characterization of VX on concrete using ion trap secondary ionization mass spectrometry
Grosman_2000_J.Gen.Physiol_115_621Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants
Grosman_2000_J.Gen.Physiol_115_637Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist
Grosman_2000_J.Gen.Physiol_116_327The extracellular linker of muscle acetylcholine receptor channels is a gating control element
Grosman_2000_J.Membr.Biol_174_59Single-channel characterization of a nonselective cation channel from human placental microvillus membranes. Large conductance, multiplicity of conductance states, and inhibition by lanthanides
Grosman_2000_Nature_403_773Mapping the conformational wave of acetylcholine receptor channel gating
Grossberg_2000_Int.J.Geriatr.Psychiatry_15_242Lack of adverse pharmacodynamic drug interactions with rivastigmine and twenty-two classes of medications
Groszek_2000_Przegl.Lek_57_577[Self-poisoning with Datura stramonium]
Grottick_2000_J.Pharmacol.Exp.Ther_294_1112Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine
Grove_2000_Toxicol.Appl.Pharmacol_162_34Differential protection by rat UDP-glucuronosyltransferase 1A7 against Benzo[a]pyrene-3,6-quinone- versus Benzo[a]pyrene-induced cytotoxic effects in human lymphoblastoid cells
Gruttadauria_2000_G.Chir_21_353Correlation between cytochrome P-450 system and liver function tests during experimental liver transplantation
Grynberg_2000_Microbiology_146 ( Pt 10)_2695The Aspergillus nidulans cysA gene encodes a novel type of serine O-acetyltransferase which is homologous to homoserine O-acetyltransferases
Gu_2000_Int.J.Dev.Neurosci_18_177Repeated immunolesions display diminished stress response signal
Gu_2000_Toxicol.Appl.Pharmacol_165_158Expression of biotransformation enzymes in human fetal olfactory mucosa: potential roles in developmental toxicity
Gualtieri_2000_Pharm.Acta.Helv_74_85Cholinergic receptors and neurodegenerative diseases
Guan_2000_Cancer.Res_60_749Drg-1 as a differentiation-related, putative metastatic suppressor gene in human colon cancer
Guerrero_2000_Insect.Biochem.Mol.Biol_30_1107Cloning of a horn fly cDNA, HialphaE7, encoding an esterase whose transcript concentration is elevated in diazinon-resistant flies
Guidry_2000_Auton.Neurosci_82_97Absence of cholinergic sympathetic innervation from limb muscle vasculature in rats and mice
Guilhermino_2000_Sci.Total.Environ_247_137In vitro and in vivo inhibition of Daphnia magna acetylcholinesterase by surfactant agents: possible implications for contamination biomonitoring
Guillou_2000_Bioorg.Med.Chem.Lett_10_637Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts
Gultekin_2000_Arch.Toxicol_74_533The effect of organophosphate insecticide chlorpyrifos-ethyl on lipid peroxidation and antioxidant enzymes (in vitro)
Gundelfinger_2000_Handb.Exp.Pharmacol_144_497Insect Nicotinic Acetylcholine Receptors: Genes, Structure, Physiological and Pharmacological Properties
Gundelfinger_2000_Naturwiss_87_513Molecular organization of excitatory chemical synapses in the mammalian brain
Gupta_2000_Alcohol_20_9Influence of ethanol on lead distribution and biochemical changes in rats exposed to lead
Gupta_2000_Hum.Exp.Toxicol_19_297Cholinergic and noncholinergic brain biomarkers of insecticide exposure and effects
Gupta_2000_Prim.Care.Companion.J.Clin.Psychiatry_2_227Acetylcholinesterase Inhibitors: Treatment of Dementia-Related Behavioral Disturbances
Gura_2000_Science_288_1718Neurobiology. Trigger found for synapse formation
Gutierrez_2000_J.Comp.Neurol_419_61Neurochemical and connectional organization of the dorsal pulvinar complex in monkeys
Guven_2000_Am.J.Emerg.Med_18_640Intravenous organophosphate intoxication
Haas_2000_Neurosci_97_25Entorhinal cortex lesion does not alter reelin messenger RNA expression in the dentate gyrus of young and adult rats
Haeggstrom_2000_Am.J.Respir.Crit.Care.Med_161_S25Structure, function, and regulation of leukotriene A4 hydrolase
Haeggstrom_2000_Ernst.Schering.Res.Found.Workshop__85Leukotriene-A4 hydrolase: probing the active sites and catalytic mechanisms by site-directed mutagenesis
Hagforsen_2000_Br.J.Dermatol_142_234The distribution of choline acetyltransferase- and acetylcholinesterase-like immunoreactivity in the palmar skin of patients with palmoplantar pustulosis
Hahn_2000_Neuropharmacol_39_2848Kappa-opioid receptor modulation of nicotine-induced behaviour
Hakulinen_2000_J.Struct.Biol_132_180Three-dimensional structure of the catalytic core of acetylxylan esterase from Trichoderma reesei: insights into the deacetylation mechanism
Hala_2000_Immunobiology_201_598Expression of nonspecific esterase (NSE) by thyroid follicular epithelium as a marker for the target organ susceptibility to immune system attack
Hall_2000_Genet.Epidemiol_18_203Frequency and allelic association of common variants in the lipoprotein lipase gene in different ethnic groups: the Wandsworth Heart and Stroke Study
Hamers_2000_Toxicol.Sci_58_60A small-volume bioassay for quantification of the esterase inhibiting potency of mixtures of organophosphate and carbamate insecticides in rainwater: development and optimization
Hand_2000_Mol.Cell.Biochem_204_65Stabilization of collagen-tailed acetylcholinesterase in muscle cells through extracellular anchorage by transglutaminase-catalyzed cross-linking
Haninec_2000_Ann.Anat_182_123Acellular nerve graft re-seeded by Schwann cells migrating from the nerve stump can stimulate spinal motoneurons for functional reinnervation of the rat muscle
Hanson_2000_Cleve.Clin.J.Med_67_441Effective treatment of Alzheimer disease and its complications
Harada_2000_Neurosci.Lett_284_163Enhancement of cerebral cortical acetylcholine release by intraperitoneal acetic acid and its suppression by analgesics in freely moving rats
Harel_2000_Protein.Sci_9_1063Three-dimensional structures of Drosophila melanogaster acetylcholinesterase and of its complexes with two potent inhibitors
Harkany_2000_Ann.N.Y.Acad.Sci_903_374beta-Amyloid excitotoxicity in rat magnocellular nucleus basalis. Effect of cortical deafferentation on cerebral blood flow regulation and implications for Alzheimer's disease
Harold_2000_Arch.Insect.Biochem.Physiol_45_47Characterization of esterases associated with profenofos resistance in the tobacco budworm, Heliothis virescens (F.)
Harris_2000_Exp.Neurol_161_517The neurotoxicity of the venom phospholipases A(2), notexin and taipoxin
Harris_2000_Food.Addit.Contam_17_491How the variability issue was uncovered: the history of the UK residue variability findings
Harte_2000_Atherosclerosis_149_343Low level expression of hormone-sensitive lipase in arterial macrophage-derived foam cells: potential explanation for low rates of cholesteryl ester hydrolysis
Hartsfield_2000_Mamm.Genome_11_915The Ephx1(d) allele encoding an Arg338Cys substitution is associated with heat lability
Hashimoto_2000_Lancet_356_568Urinary incontinence: an unrecognised adverse effect with donepezil
Hasler_2000_Gastroenterology_118_443Neostigmine for acute colonic pseudo-obstruction: new use for an old drug?
Hathway_2000_Biol.Rev.Camb.Philos.Soc_75_95Toxic action/toxicity
Hatjian_2000_Mutat.Res_472_85Cytogenetic response without changes in peripheral cholinesterase enzymes following exposure to a sheep dip containing diazinon in vivo and in vitro
Hattori_2000_Endocrinology_141_3353Epoxide hydrolase affects estrogen production in the human ovary
Hattori_2000_Nature_405_311The DNA sequence of human chromosome 21
Hauber_2000_Clin.Ther_22_439Savings in the cost of caring for patients with Alzheimer's disease in Canada: an analysis of treatment with rivastigmine
Haux_2000_Chem.Res.Toxicol_13_646Phosphobutyrylcholinesterase: phosphorylation of the esteratic site of butyrylcholinesterase by ethephon [(2-chloroethyl)phosphonic acid] dianion
Hayashi_2000_Brain.Res_858_167The development of terminal schwann cells associated with periodontal ruffini endings in the rat incisor ligament
Hayashi_2000_Gene.Ther_7_1664In vivo transfer of human hepatocyte growth factor gene accelerates re-endothelialization and inhibits neointimal formation after balloon injury in rat model
Hayashida_2000_Genomics_66_221Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32
Hayes_2000_Neurosci.Lett_287_146Human rotation-mediated fetal mixed brain cell aggregate culture: characterization and N-methyl-D-aspartate toxicity
He_2000_Neurotoxicol_21_829Neurotoxic effects of insecticides--current and future research: a review
Heidelberg_2000_Nature_406_477DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae
Heijenbrok_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_362_504The influence of chronic inhibition of nitric oxide synthesis on contractile and relaxant properties of rat carotid and mesenteric arteries
Hein_2000_Drug.Metab.Dispos_28_1425Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber
Heindl_2000_Dtsch.Med.Wochenschr_125_1361[Etiology of initially unexplained confusion of excitability in deadly nightshade poisoning with suicidal intent. Symptoms, differential diagnosis, toxicology and physostigmine therapy of anticholinergic syndrome]
Heinonen_2000_Mol.Genet.Metab_69_123Expression of palmitoyl protein thioesterase in neurons
Heinonen_2000_Molec.Genet.Metab_69_123Expression of palmitoyl protein thioesterase in neurons.
Heinzmann_2000_Clin.Exp.Allergy_30_1555Studies on linkage and association of atopy with the chromosomal region 12q13-24
Heller_2000_Acta.Anaesthesiol.Scand_44_1024Epidural abscess after epidural catheter for pain release during pancreatitis
Hellgren_2000_Cell.Mol.Life.Sci_57_175Muscarinic M3 receptor subtype gene expression in the human heart
Hellstrom-Lindahl_2000_Behav.Brain.Res_113_159Nicotinic acetylcholine receptors during prenatal development and brain pathology in human aging
Hellstrom-Lindahl_2000_Eur.J.Pharmacol_393_255Modulation of beta-amyloid precursor protein processing and tau phosphorylation by acetylcholine receptors
Hellstrom-Lindahl_2000_J.Neurochem_74_777Increased levels of tau protein in SH-SY5Y cells after treatment with cholinesterase inhibitors and nicotinic agonists
Hengstler_2000_Drug.Metab.Rev_32_81Cryopreserved primary hepatocytes as a constantly available in vitro model for the evaluation of human and animal drug metabolism and enzyme induction
Henne_2000_Appl.Environ.Microbiol_66_3113Screening of environmental DNA libraries for the presence of genes conferring lipolytic activity on Escherichia coli
Heo_2000_Mol.Cells_10_253Inhibitory effect of Artemisia asiatica alkaloids on acetylcholinesterase activity from rat PC12 cells
Herholz_2000_J.Neural.Transm.(Vienna)_107_1457In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism
Hering_2000_J.Comp.Neurol_424_153Distribution of the integrin beta 1 subunit on radial cells in the embryonic and adult avian retina
Hernaez_2000_J.Bacteriol_182_5448Identification of a serine hydrolase which cleaves the alicyclic ring of tetralin
Hernandez_2000_Insect.Biochem.Mol.Biol_30_969Identification of a point mutation in an esterase gene in different populations of the southern cattle tick, Boophilus microplus
Hernandez_2000_J.Pharmacol.Exp.Ther_293_962Dextromethorphan and its metabolite dextrorphan block alpha3beta4 neuronal nicotinic receptors
Herrgard_2000_Biochemistry_39_2921Role of an electrostatic network of residues in the enzymatic action of the Rhizomucor miehei lipase family
Herrman_2000_Food.Addit.Contam_17_551Acute intake assessment: evolution within the Codex Committee on Pesticide Residues. WHO Joint Secretary of the Joint FAO/WHO meeting on pesticide residues JMPR
Hersi_2000_Brain.Res.Mol.Brain.Res_76_336Dopamine D-5 receptor modulates hippocampal acetylcholine release
Hess_2000_Proc.Natl.Acad.Sci.U.S.A_97_13895Mechanism-based discovery of ligands that counteract inhibition of the nicotinic acetylcholine receptor by cocaine and MK-801
Heuser_2000_N.Engl.J.Med_342_1674; author reply 1675Mass psychogenic illness attributed to toxic exposure at a high school
Hewitt_2000_Drug.Metab.Dispos_28_755Metabolism of fluroxypyr, fluroxypyr methyl ester, and the herbicide fluroxypyr methylheptyl ester. II: in rat skin homogenates
Hicks_2000_J.Physiol_529 Pt 3_579Regulation of the sensitivity of acetylcholine receptors to nicotine in rat habenula neurons
Higashijima_2000_J.Neurosci_20_206Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the islet-1 promoter/enhancer
Hill_2000_Food.Addit.Contam_17_539Residue variability and sampling--practical problems and consequences for residues monitoring
Hill_2000_Toxicon_38_1663Characterization of venom (Duvernoy's secretion) from twelve species of colubrid snakes and partial sequence of four venom proteins
Himmel_2000_Mol.Pharmacol_58_449Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes
Hiol_2000_Enzyme.Microb.Technol_26_421Purification and characterization of an extracellular lipase from a thermophilic Rhizopus oryzae strain isolated from palm fruit
Hirabayashi_2000_Eur.J.Biochem_267_2525M1 muscarinic acetylcholine receptors activate zif268 gene expression via small G-protein Rho-dependent and lambda-independent pathways in PC12D cells
Hirashima_2000_Bioorg.Med.Chem_8_653Docking study of enantiomeric fonofos oxon bound to the active site of Torpedo californica acetylcholinesterase
Hiratsu_2000_Mol.Gen.Genet_263_1015Cloning and analysis of the replication origin and the telomeres of the large linear plasmid pSLA2-L in Streptomyces rochei
Hishinuma_2000_Endocrinology_141_4050A novel missense mutation (G2320R) in thyroglobulin causes hypothyroidism in rdw rats
Ho_2000_Yeast_17_272Comparison of Mycobacterium tuberculosis genomes reveals frequent deletions in a 20 kb variable region in clinical isolates
Hock_2000_Ann.N.Y.Acad.Sci_920_285Treatment with the selective muscarinic agonist talsaclidine decreases cerebrospinal fluid levels of total amyloid beta-peptide in patients with Alzheimer's disease
Hock_2000_Praxis.(Bern.1994)_89_529[Alzheimer dementia]
Hoffer_2000_Atherosclerosis_151_443The V73M mutation in the hepatic lipase gene is associated with elevated cholesterol levels in four Dutch pedigrees with familial combined hyperlipidemia
Hoffmann_2000_FEMS.Microbiol.Lett_184_253The Pseudomonas aeruginosa phaG gene product is involved in the synthesis of polyhydroxyalkanoic acid consisting of medium-chain-length constituents from non-related carbon sources
Hoffmann_2000_J.Clin.Endocrinol.Metab_85_4795Type I hyperlipoproteinemia due to a novel loss of function mutation of lipoprotein lipase, Cys(239)-->Trp, associated with recurrent severe pancreatitis
Hoglund_2000_J.Pharmacol.Exp.Ther_295_100Effects of microdialyzed oxotremorine, carbachol, epibatidine, and scopolamine on intraspinal release of acetylcholine in the rat
Holley_2000_Curr.Top.Dev.Biol_47_247Somitogenesis in zebrafish
Holm_2000_Annu.Rev.Nutr_20_365Molecular mechanisms regulating hormone-sensitive lipase and lipolysis
Holmer_2000_Cardiovasc.Res_47_806Lipoprotein lipase gene polymorphism, cholesterol subfractions and myocardial infarction in large samples of the general population
Holmes_2000_N.Z.Med.J_113_129Fantasy-drug of abuse
Holmquist_2000_Curr.Protein.Pept.Sci_1_209Alpha/Beta-hydrolase fold enzymes: structures, functions and mechanisms
Holz_2000_J.Biol.Chem_275_17878A pleckstrin homology domain specific for phosphatidylinositol 4, 5-bisphosphate (PtdIns-4,5-P2) and fused to green fluorescent protein identifies plasma membrane PtdIns-4,5-P2 as being important in exocytosis
Holzgrabe_2000_Pharm.Acta.Helv_74_149Ligands for the common allosteric site of acetylcholine M2-receptors: development and application
Holzl_2000_J.Lipid.Res_41_734Two novel mutations in the lipoprotein lipase gene in a family with marked hypertriglyceridemia in heterozygous carriers. Potential interaction with the polymorphic marker D1S104 on chromosome 1q21-q23
Homma_2000_Alzheimer.Dis.Assoc.Disord_14 Suppl 1_S123Current status of clinical trials for Alzheimer-type dementia in Japan: strategies to facilitate the development of antidementia drugs
Homma_2000_Dement.Geriatr.Cogn.Disord_11_299Clinical efficacy and safety of donepezil on cognitive and global function in patients with Alzheimer's disease. A 24-week, multicenter, double-blind, placebo-controlled study in Japan. E2020 Study Group
Honda_2000_Brain.Res_859_38Involvement of M(3) muscarinic receptors of the spinal cord in formalin-induced nociception in mice
Hong_2000_Proc.Natl.Acad.Sci.U.S.A_97_8717An ethylene-induced cDNA encoding a lipase expressed at the onset of senescence.
Horti_2000_Life.Sci_67_4636-[18F]fluoro-A-85380, a novel radioligand for in vivo imaging of central nicotinic acetylcholine receptors
Horton_2000_Parasitol_121 Suppl_S147An analysis of the safety of the single dose, two drug regimens used in programmes to eliminate lymphatic filariasis
Horvath_2000_Eur.J.Pharmacol_405_33Postnatal treatment with ACTH-(4-9) analog ORG 2766 attenuates N-methyl-D-aspartate-induced excitotoxicity in rat nucleus basalis in adulthood
Hoshino_2000_Vis.Neurosci_17_893Distribution of terminals from pedunculopontine tegmental nucleus and synaptic organization in lateralis medialis-suprageniculate nucleus of cat's thalamus: anterograde tracing, immunohistochemical studies, and quantitative analysis
Hosli_2000_Int.J.Dev.Neurosci_18_101Histochemical and electrophysiological evidence for estrogen receptors on cultured astrocytes: colocalization with cholinergic receptors
Hosli_2000_Neurochem.Int_36_301Colocalization of neurotransmitter receptors on astrocytes in explant cultures of rat CNS
Hosoda_2000_Biochem.Biophys.Res.Commun_279_909Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue
Hou_2000_Am.J.Chin.Med_28_379Honokiol and magnolol increased hippocampal acetylcholine release in freely-moving rats
Houlihan_2000_Neuropharmacol_39_2533Effects of diltiazem on human nicotinic acetylcholine and GABA(A) receptors
Houston_2000_Parasitol_121 Suppl_S161Salt fortified with diethylcarbamazine (DEC) as an effective intervention for lymphatic filariasis, with lessons learned from salt iodization programmes
Hoyos_2000_J.Pineal.Res_28_150Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats
Hu_2000_Proc.Natl.Acad.Sci.U.S.A_97_9543Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
Huang_2000_Genetics_156_1219A misexpression screen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster
Huang_2000_Neurosci.Lett_284_116Cloning, heterologous expression and co-assembly of Mpbeta1, a nicotinic acetylcholine receptor subunit from the aphid Myzus persicae
Hube_2000_Arch.Microbiol_174_362Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members
Huckstorf_2000_Brain.Res.Dev.Brain.Res_119_169Effects of hindlimb unloading on neuromuscular development of neonatal rats
Hung_2000_Fundam.Clin.Pharmacol_14_387Identification of opioid receptors in the sympathetic and parasympathetic nerves of guinea-pig atria
Hunt_2000_Cell.Biochem.Biophys_32 Spring_317Acyl-CoA thioesterases belong to a novel gene family of peroxisome proliferator-regulated enzymes involved in lipid metabolism
Hunt_2000_FEMS.Microbiol.Lett_192_249Characterisation of a Pasteurella multocida esterase gene which confers a hemolytic phenotype in Escherichia coli under anaerobic conditions
Hurh_2000_Biopharm.Drug.Dispos_21_331Effects of physostigmine on the pharmacokinetics of intravenous parathion in rats
Hussein_2000_Eur.J.Biochem_267_2276Determinants of substrate specificity of a second non-neuronal secreted acetylcholinesterase from the parasitic nematode Nippostrongylus brasiliensis
Huxley_2000_Philos.Trans.R.Soc.Lond.B.Biol.Sci_355_539Past, present and future experiments on muscle
Hwang_2000_Anesth.Analg_90_421An analysis of drug interaction between morphine and neostigmine in rats with nerve-ligation injury
Iannaccone_2000_Muscle.Nerve_23_1129Congenital myasthenic syndrome with sleep hypoventilation
Iannazzo_2000_Br.J.Pharmacol_130_2008No involvement of nicotinic receptors in the facilitation of acetylcholine outflow in mouse cortex in the presence of neostigmine and atropine
Ikarashi_2000_J.Chromatogr.B.Biomed.Sci.Appl_742_295Effect of 2-deoxy-D-glucose on acetylcholine and histamine levels in gastric juice of pylorus-ligated rats anesthetized with urethane
Ikeda_2000_Clin.Sci.(Lond)_99_569A compound heterozygote for a novel missense mutation (G105R) in exon 3 and a missense mutation (D204E) in exon 5 of the lipoprotein lipase gene in a Japanese infant with hyperchylomicronaemia
Ikemoto_2000_Nihon.Hinyokika.Gakkai.Zasshi_91_556[Changes in liver function induced by flutamide in patients with prostate cancer (studies in patients treated with total androgen blockage)]
Iliev_2000_J.Pharm.Pharmacol_52_1151A post-ischaemic single administration of galanthamine, a cholinesterase inhibitor, improves learning ability in rats
Imai_2000_Genetics_155_261Analysis of chromosomal rearrangements induced by postmeiotic mutagenesis with ethylnitrosourea in zebrafish
Imamura_2000_J.Biochem_127_419Purification and characterization of a monoacylglycerol lipase from the moderately thermophilic Bacillus sp. H-257
Imbimbo_2000_Dement.Geriatr.Cogn.Disord_11_17A 6-month, double-blind, placebo-controlled trial of eptastigmine in Alzheimer's disease
Inestrosa_2000_Acta.Neurol.Scand.Suppl_176_53Acetylcholinesterase-amyloid-beta-peptide interaction and Wnt signaling involvement in Abeta neurotoxicity
Ingkaninan_2000_J.Chromatogr.A_872_61High-performance liquid chromatography with on-line coupled UV, mass spectrometric and biochemical detection for identification of acetylcholinesterase inhibitors from natural products
Ingkaninan_2000_J.Nat.Prod_63_803The application of HPLC with on-line coupled UV/MS-biochemical detection for isolation of an acetylcholinesterase inhibitor from narcissus 'Sir Winston Churchill'
Inoue_2000_Biochem.Biophys.Res.Commun_268_553Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains
Ishigaki_2000_J.Biosci.Bioeng_90_400Enzymatic degradation of cellulose acetate plastic by Novel degrading bacterium Bacillus sp. S2055
Ishihara_2000_Curr.Med.Chem_7_341Central Selective Acetylcholinesterase Inhibitor with Neurotrophic Activity: Structure-Activity Relationships of TAK-147 and Related Compounds
Israel_2000_Trends.Neurosci_23_47Ladislav Tauc (1926-1999)
Ito_2000_J.Biochem_128_673Substrate recognition mechanism of prolyl aminopeptidase from Serratia marcescens
Iturriaga_2000_Brain.Res_868_380Lack of correlation between cholinergic-induced changes in chemosensory activity and dopamine release from the cat carotid body in vitro
Iwagami_2000_Appl.Environ.Microbiol_66_1499Characterization of the protocatechuic acid catabolic gene cluster from Streptomyces sp. strain 2065
Izurieta-Sanchez_2000_Brain.Res_856_250Neostigmine influences the L-dopa-induced extracellular dopamine levels in the striatum
Jacoby_2000_Am.J.Physiol.Lung.Cell.Mol.Physiol_279_L59Effects of neurokinin receptor antagonists in virus-infected airways
Jaeger_2000_Curr.Opin.Chem.Biol_4_68Directed evolution of enantioselective enzymes for organic chemistry
Jaganathan_2000_BMC.Biochem_1_3A direct method to visualise the aryl acylamidase activity on cholinesterases in polyacrylamide gels
Jaganathan_2000_Bioorg.Chem_28_242Distinct Effect of Benzalkonium Chloride on the Esterase and Aryl Acylamidase Activities of Butyrylcholinesterase
Jain_2000_Expert.Opin.Investig.Drugs_9_1397Evaluation of memantine for neuroprotection in dementia
Jakubik_2000_J.Biol.Chem_275_18836Evidence for a tandem two-site model of ligand binding to muscarinic acetylcholine receptors
Jakubowski_2000_J.Nutr_130_377SHomocysteine thiolactone: metabolic origin and protein homocysteinylation in humans
James_2000_Circulation_101_2252Smoking is associated with reduced serum paraoxonase activity and concentration in patients with coronary artery disease
James_2000_Diabetes_49_1390Promoter polymorphism T(-107)C of the paraoxonase PON1 gene is a risk factor for coronary heart disease in type 2 diabetic patients
Jamroz_2000_J.Insect.Physiol_46_685Molecular and biochemical survey of acaricide resistance mechanisms in larvae from Mexican strains of the southern cattle tick, Boophilus microplus
Jann_2000_J.Am.Pharm.Assoc.(Wash)_40_S50Supportive care for the patient with Alzheimer's disease
Jann_2000_Pharmacotherapy_20_1Rivastigmine, a new-generation cholinesterase inhibitor for the treatment of Alzheimer's disease
Jaspers_2000_J.Bacteriol_182_405HbpR, a new member of the XylR/DmpR subclass within the NtrC family of bacterial transcriptional activators, regulates expression of 2-hydroxybiphenyl metabolism in Pseudomonas azelaica HBP1
Jenkins_2000_Sci.Total.Environ_250_73Phosphine generation by mixed- and monoseptic-cultures of anaerobic bacteria
Jensen_2000_J.Econ.Entomol_93_464Mechanisms associated with methiocarb resistance in Frankliniella occidentalis (Thysanoptera: Thripidae)
Jensen_2000_Ugeskr.Laeger_162_161[Mutation of the plasma cholinesterase gene and anesthesia. Information from the Danish Cholinesterase Registry]
Jerusalinsky_2000_Toxicon_38_747Muscarinic toxins: novel pharmacological tools for the muscarinic cholinergic system
Jesenska_2000_Appl.Environ.Microbiol_66_219Dehalogenation of haloalkanes by Mycobacterium tuberculosis H37Rv and other mycobacteria
Jett_2000_Neurotoxicol_21_141In vitro and in vivo effects of chlorpyrifos on glutathione peroxidase and catalase in developing rat brain
Jeyarasasingam_2000_J.Pharmacol.Exp.Ther_295_314Nitric oxide is involved in acetylcholinesterase inhibitor-induced myopathy in rats
Jeyarasasingam_2000_Neuroreport_11_1173Tacrine, a reversible acetylcholinesterase inhibitor, induces myopathy
Ji_2000_Anat.Rec_259_86Intrinsic interrelation of lymphatic endothelia with nerve elements in the monkey urinary bladder
Ji_2000_J.Neurophysiol_83_2682Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons
Jia_2000_Biochemistry_39_3927Lipases provide a new mechanistic model for polyhydroxybutyrate (PHB) synthases: characterization of the functional residues in chromatium vinosum PHB synthase
Jing_2000_Embo.J_19_164New structural motifs on the chymotrypsin fold and their potential roles in complement factor B
Johnson_2000_Appl.Biochem.Biotechnol_83_131Localization of a novel adhesion-promoting site on acetylcholinesterase using catalytic antiacetylcholinesterase antibodies displaying cholinesterase-like activity
Johnson_2000_Int.J.Dev.Neurosci_18_781Cholinesterases modulate cell adhesion in human neuroblastoma cells in vitro
Johnson_2000_Mol.Immunol_37_707Cholinesterase-like catalytic antibodies: reaction with substrates and inhibitors
Johnson_2000_Mol.Plant.Microbe.Interact_13_742Cloning and characterization of a cyclic peptide synthetase gene from Alternaria alternata apple pathotype whose product is involved in AM-toxin synthesis and pathogenicity
Jonas_2000_Biochim.Biophys.Acta_1529_245Lecithin cholesterol acyltransferase
Jones_2000_Biochem.Biophys.Res.Commun_275_233Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase.
Jones_2000_Biochem.J_346 Pt 1_233Regulation of the juvenile hormone esterase gene by a composite core promoter
Jones_2000_Eur.J.Pharmacol_391_105Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats
Jones_2000_J.Bacteriol_182_2018sal genes determining the catabolism of salicylate esters are part of a supraoperonic cluster of catabolic genes in Acinetobacter sp. strain ADP1
Jones_2000_J.Pharmacol.Exp.Ther_294_1017Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex
Jones_2000_J.Toxicol.Environ.Health.A_61_695Subchronic effects following a single sarin exposure on blood-brain and blood-testes barrier permeability, acetylcholinesterase, and acetylcholine receptors in the central nervous system of rat: a dose-response study
Jose_2000_Neuropharmacol_39_2808Nicotine-induced fos expression in the pedunculopontine mesencephalic tegmentum in the rat
Jourenkova-Mironova_2000_Cancer.Res_60_534High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers
Julien_2000_Gene_249_153Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
Jung_2000_Neurosci_97_495Targeted disruption of the dopamine D(2) and D(3) receptor genes leads to different alterations in the expression of striatal calbindin-D(28k)
Jutila_2000_Biophys.J_78_1634Detergent-induced conformational changes of Humicola lanuginosa lipase studied by fluorescence spectroscopy
Kadono-Okuda_2000_Biochem.Biophys.Res.Commun_272_12Distinctive structural and kinetic properties of an unusual juvenile hormone-hydrolyzing esterase
Kahl_2000_Neurosci.Lett_285_17Influence of muscarinic ligands on the amplitudes of the evoked surface potential's late components in the optic tectum of the urodele Plethodon jordani
Kaiser_2000_Handb.Exp.Pharmacol_144_193Presynaptic Neuronal Nicotinic Receptors: Pharmacology, Heterogeneity, and Cellular Mechanisms
Kaiser_2000_Mol.Pharmacol_58_312alpha-bungarotoxin-sensitive nicotinic receptors indirectly modulate [(3)H]dopamine release in rat striatal slices via glutamate release
Kaksonen_2000_J.Cell.Sci_113 Pt 24_4421Association of cortactin with dynamic actin in lamellipodia and on endosomal vesicles
Kalaydjieva_2000_Am.J.Hum.Genet_67_47N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom
Kamal_2000_Biochem.Pharmacol_60_561Kinetics of human acetylcholinesterase inhibition by the novel experimental Alzheimer therapeutic agent, tolserine
Kamal_2000_J.Enzyme.Inhib_15_201Dual substrate model for novel approach towards a kinetic study of acetylcholinesterase inhibition by diazinon
Kamal_2000_Proc.Natl.Sci.Counc.Repub.China.B_24_108Thermodynamic analysis of human retinal acetylcholinesterase inhibition using an anti-Alzheimer's drug, tacrine, through the development of a dual substrate and temperature model
Kamei_2000_Brain.Res_887_183Mechanism responsible for epileptogenic activity by first-generation H1-antagonists in rats
Kandel_2000_Brain.Res.Brain.Res.Rev_32_3Michael V.L. Bennett and the cellular study of neural systems at Albert Einstein and Woods Hole
Kaneko_2000_DNA.Res_7_217Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC clones
Kaneko_2000_DNA.Res_7_331Complete genome structure of the nitrogen-fixing symbiotic bacterium Mesorhizobium loti
Kaneko_2000_Hepatogastroenterology_47_1636A new method of functional scintiphotosplenoportography using technetium-99m-DTPA-galactosylated human serum albumin
Kaneko_2000_Methods.Find.Exp.Clin.Pharmacol_22_163The mechanism responsible for the drowsiness caused by first generation H1 antagonists on the EEG pattern
Kanno_2000_Rinsho.Byori__21[Investigative application of a laboratory database]
Kansal_2000_J.Control.Release_68_157An observational study on neurobehavioural effects of acute oxydemeton-methyl (insecticide and acaricide) exposure in rats
Karan_2000_Methods.Find.Exp.Clin.Pharmacol_22_169Effect of muscarinic receptor agonists on animal models of psychosis
Karch_2000_Am.J.Emerg.Med_18_635Interpretation of blood cocaine and metabolite concentrations
Kardos_2000_Toxicol.Sci_58_118Interactions of the organophosphates paraoxon and methyl paraoxon with mouse brain acetylcholinesterase
Karlsson_2000_Biochimie_82_793Snake toxins with high selectivity for subtypes of muscarinic acetylcholine receptors
Karlsson_2000_Protein.Expr.Purif_18_286Expression, purification, and characterization of histidine-tagged mouse monoglyceride lipase from baculovirus-infected insect cells
Karpouzas_2000_J.Appl.Microbiol_89_40Factors influencing the ability of Pseudomonas putida strains epI and II to degrade the organophosphate ethoprophos
Karunaratne_2000_Med.Vet.Entomol_14_430Insecticide resistance spectra and resistance mechanisms in populations of Japanese encephalitis vector mosquitoes, Culex tritaeniorhynchus and Cx. gelidus, in Sri Lanka
Kasa_2000_Neurosci.Lett_278_117Human amyloid-beta1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat
Kasa_2000_Neurosci_101_89Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain
Kashima_2000_J.Biosci.Bioeng_89_81Role of intracellular esterases in the production of esters by Acetobacter pasteurianus
Kassa_2000_Cas.Lek.Cesk_139_237[Importance of reactivation of fosdrin-inhibited acetylcholinesterase in the brain and diaphragm for the in vivo therapeutic effect of oximes in rats poisoned with fosdrin]
Kassa_2000_Pharmacol.Biochem.Behav_67_663Neuroprotective effects of currently used antidotes in soman-poisoned rats
Katami_2000_J.Agric.Food.Chem_48_2499Migration of organophosphorus insecticides cyanophos and prothiofos residues from impregnated paper bags to Japanese apple-pears (Pyrus pyrifolia nakai cv. Nijisseiki)
Kataoka_2000_Eur.J.Biochem_267_33,4-Dihydrocoumarin hydrolase with haloperoxidase activity from Acinetobacter calcoaceticus F46
Kato_2000_J.Anesth_14_30Inhibition of human plasma cholinesterase and erythrocyte acetylcholinesterase by nondepolarizing neuromuscular blocking agents
Kato_2000_J.Biosci.Bioeng_90_332Efficient preparation of optically active ketoprofen by Mucor javanicus lipase immobilized on an inorganic support
Kato_2000_Microbiol.Immunol_44_719Molecular cloning and partial characterization of rat procarboxypeptidase R and carboxypeptidase N
Katsoudas_2000_J.Food.Prot_63_1758Enzyme inhibition and enzyme-linked immunosorbent assay methods for carbamate pesticide residue analysis in fresh produce
Katz_2000_Hear.Res_141_117High calcium permeability and calcium block of the alpha9 nicotinic acetylcholine receptor
Kauderer_2000_Proc.Natl.Acad.Sci.U.S.A_97_13342Capture of a protein synthesis-dependent component of long-term depression
Kaur_2000_Curr.Med.Chem_7_273Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors
Kawahara_2000_Org.Lett_2_675An efficient synthesis of optically active physostigmine from tryptophan via alkylative cyclization
Kawai_2000_Biochemistry_39_3867Interaction of a semirigid agonist with Torpedo acetylcholine receptor
Kawasaki_2000_J.Hand.Surg.[Am]_25_104Identification of myelinated motor and sensory axons in a regenerating mixed nerve
Kawashima_2000_Pharmacol.Ther_86_29Extraneuronal cholinergic system in lymphocytes
Kawashima_2000_Proc.Natl.Acad.Sci.U.S.A_97_14257Archaeal adaptation to higher temperatures revealed by genomic sequence of Thermoplasma volcanium
Keifer_2000_Am.J.Prev.Med_18_80Effectiveness of interventions in reducing pesticide overexposure and poisonings
Keller_2000_J.Neurochem_74_1739Modification of cysteines reveals linkage to acetylcholine and vesamicol binding sites in the vesicular acetylcholine transporter of Torpedo californica
Keller_2000_Neurochem.Int_36_113A critical histidine in the vesicular acetylcholine transporter
Kelton_2000_Brain.Cogn_43_274The effects of nicotine on Parkinson's disease
Kenny_2000_Brain.Res.Mol.Brain.Res_85_234Acute nicotine decreases, and chronic nicotine increases the expression of brain-derived neurotrophic factor mRNA in rat hippocampus
Kenny_2000_J.Neurochem_75_2409Evidence for a complex influence of nicotinic acetylcholine receptors on hippocampal serotonin release
Kenny_2000_Neuropharmacol_39_300Anxiogenic effects of nicotine in the dorsal hippocampus are mediated by 5-HT1A and not by muscarinic M1 receptors
Kerjean_2000_Hum.Mol.Genet_9_2183Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis
Kerr_2000_Clin.Exp.Pharmacol.Physiol_27_934Effects of tachykinin receptor agonists and antagonists on the guinea-pig isolated oesophagus
Kessler_2000_Cancer.Res_60_1403Identification of the putative brain tumor antigen BF7/GE2 as the (de)toxifying enzyme microsomal epoxide hydrolase
Keyser_2000_Vis.Neurosci_17_743Amacrine, ganglion, and displaced amacrine cells in the rabbit retina express nicotinic acetylcholine receptors
Khakh_2000_Nature_406_405State-dependent cross-inhibition between transmitter-gated cation channels
Khan_2000_Toxicol.Sci_57_112Acute sarin exposure causes differential regulation of choline acetyltransferase, acetylcholinesterase, and acetylcholine receptors in the central nervous system of the rat
Khanna_2000_Cancer.Res_60_4725Proficient metabolism of irinotecan by a human intestinal carboxylesterase
Khrunin_2000_Gig.Sanit__66[Anticholinesterase effect of potential organophosphorus synergists of pyrethroids]
Khurana_2000_Arch.Neurol_57_600Organophosphorus intoxication
Kiderlen_2000_Arch.Toxicol_74_27The phosphoryl oxime-destroying activity of human plasma
Kikuchi_2000_Ecotoxicol.Environ.Saf_47_239Screening of organophosphate insecticide pollution in water by using Daphnia magna
Kikusui_2000_Pharmacol.Biochem.Behav_65_131The allocentric place discrimination task is selectively and highly dependent on the central muscarinic system in rats
Kim_2000_Environ.Res_84_303A convenient method for oxidation of organophosphorus pesticides in organic solvents
Kim_2000_Food.Addit.Contam_17_469Determination of ethyl carbamate in some fermented Korean foods and beverages
Kim_2000_J.Biol.Chem_275_6175Mutational analysis of basic residues in the rat vesicular acetylcholine transporter. Identification of a transmembrane ion pair and evidence that histidine is not involved in proton translocation
Kim_2000_Liver_20_319Inhibition of lipopolysaccharide-induced I-kappaB degradation and tumor necrosis factor-alpha expression by dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB): minor role in hepatic detoxifying enzyme expression
Kim_2000_Mol.Endocrinol_14_1944A missense mutation G2320R in the thyroglobulin gene causes non-goitrous congenital primary hypothyroidism in the WIC-rdw rat
Kimata-Ariga_2000_EMBO.J_19_5041Differential electron flow around photosystem I by two C(4)-photosynthetic-cell-specific ferredoxins
Kimura_2000_Am.J.Ophthalmol_130_769Genetic association of manganese superoxide dismutase with exudative age-related macular degeneration
Kimura_2000_J.Exp.Zool_286_656cDNA cloning of rat prolyl oligopeptidase and its expression in the ovary during the estrous cycle
Kitamura_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_126_259Whole-body metabolism of the organophosphorus pesticide, fenthion, in goldfish, Carassius auratus
Kittl_2000_Clin.Chem.Lab.Med_38_205Serum protein 90K/Mac-2BP is an independent predictor of disease severity during hepatitis C virus infection
Kivela_2000_Duodecim_116_1016[Lice and crab lice in the eye lashes]
Kleinjung_2000_Biopolymers_53_113The third-dimensional structure of the complex between an Fv antibody fragment and an analogue of the main immunogenic region of the acetylcholine receptor: a combined two-dimensional NMR, homology, and molecular modeling approach
Klichkhanov_2000_Biull.Eksp.Biol.Med_129_326[Temperature-dependent activity of acetylcholinesterase in synaptic membranes from the rat brain during hypothermia]
Kliman_2000_Genetics_156_1913The population genetics of the origin and divergence of the Drosophila simulans complex species
Kluchova_2000_Bratisl.Lek.Listy_101_18[Coexistence of cholinergic and nitrergic neurotransmitters in the spinal cord of rabbits]
Kluchova_2000_Physiol.Res_49_151Partial colocalization of NADPH-diaphorase and acetylcholinesterase positivity in spinal cord neurons
Knopman_2000_Int.J.Neuropsychopharmacol_3_13Management of cognition and function: new results from the clinical trials programme of Aricept(R) (donepezil HCl)
Knott_2000_Methods.Find.Exp.Clin.Pharmacol_22_115Pharmaco-EEG test dose response predicts cholinesterase inhibitor treatment outcome in Alzheimer's disease
Knott_2000_Neuropsychobiology_41_210Acute nicotine administration in Alzheimer's disease: an exploratory EEG study
Kobayashi_2000_FEMS.Microbiol.Lett_188_165Accumulation of an artificial cell wall-binding lipase by Bacillus subtilis wprA and/or sigD mutants
Kobayashi_2000_J.Biosci.Bioeng_90_422Accumulation of a recombinant Aspergillus oryzae lipase artificially localized on the Bacillus subtilis cell surface
Koebmann_2000_J.Bacteriol_182_4738The membrane bound H+-ATPase complex is essential for growth of Lactococcus lactis.
Koellner_2000_J.Mol.Biol_296_713Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica
Koenig_2000_Rev.Reprod_5_189Role of progesterone in peripheral nerve repair
Kofalvi_2000_J.Pharmacol.Exp.Ther_295_453Long-lasting facilitation of 4-amino-n-[2,3-(3)H]butyric acid ([(3)H]GABA) release from rat hippocampal slices by nicotinic receptor activation
Kohn_2000_Environ.Health.Perspect_108 Suppl 5_911The privileged access model of 1,3-butadiene disposition
Kojic_2000_Proc.Natl.Acad.Sci.U.S.A_97_1841Columnar distribution of serotonin-dependent plasticity within kitten striate cortex
Kolaczinski_2000_Bull.Entomol.Res_90_125Experimental and molecular genetic analysis of the impact of pyrethroid and non-pyrethroid insecticide impregnated bednets for mosquito control in an area of pyrethroid resistance
Kolesnikov_2000_Proc.Natl.Acad.Sci.U.S.A_97_13526Enzyme mimicry by the antiidiotypic antibody approach
Kolf-Clauw_2000_Vet.Hum.Toxicol_42_216Acetyl- and pseudo-cholinesterase activities of plasma, erythrocytes, and whole blood in male beagle dogs using Ellman's assay
Kontou_2000_Eur.J.Biochem_267_2389The crystal structure of the Fab fragment of a rat monoclonal antibody against the main immunogenic region of the human muscle acetylcholine receptor
Koppenhofer_2000_J.Econ.Entomol_93_71Biological control agents for white grubs (Coleoptera: Scarabaeidae) in anticipation of the establishment of the Japanese beetle in California
Korczyn_2000_Expert.Opin.Investig.Drugs_9_2259Muscarinic M(1) agonists in the treatment of Alzheimer's disease
Kosaki_2000_Am.J.Hum.Genet_66_309Isoform-specific imprinting of the human PEG1/MEST gene
Kosasa_2000_Eur.J.Pharmacol_389_173Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats
Koudinova_2000_Neurochem.Res_25_653Alzheimer's Abeta1-40 peptide modulates lipid synthesis in neuronal cultures and intact rat fetal brain under normoxic and oxidative stress conditions
Koutcherov_2000_J.Comp.Neurol_423_299Organization of the human paraventricular hypothalamic nucleus
Kovoor_2000_J.Biol.Chem_275_3397Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins
Kozlowski_2000_Bioorg.Med.Chem.Lett_10_2255Diphenyl sulfoxides as selective antagonists of the muscarinic M2 receptor
Kraut_2000_Mol.Pharmacol_57_1243Inactivation studies of acetylcholinesterase with phenylmethylsulfonyl fluoride
Kreft_2000_Pflugers.Arch_439_r066Nonradioactive northern blotting for the determination of acetylcholinesterase mRNA. Comparison to the radioactive technique
Kretzschmar_2000_Anaesthesiol.Reanim_25_37[Initiation of lipid peroxidation (LPO) in blood during intraoperative mechanical autotransfusion--is hepatotoxicity of lipid peroxidation products of clinical significance?]
Krieger_2000_Arch.Environ.Contam.Toxicol_38_546Malathion deposition, metabolite clearance, and cholinesterase status of date dusters and harvesters in California
Krishnamoorthy_2000_Indian.J.Med.Res_111_81Cost of mass annual single dose diethylcarbamazine distribution for the large scale control of lymphatic filariasis
Kristensen_2000_J.Econ.Entomol_93_1788Selection and reversion of azamethipos-resistance in a field population of the housefly Musca domestica (Diptera: Muscidae), and the underlying biochemical mechanisms
Krivit_2000_Bone.Marrow.Transplant_26_567Wolman disease successfully treated by bone marrow transplantation
Krnjevic_2000_J.Neurophysiol_83_8792-Deoxyglucose-induced long-term potentiation of monosynaptic IPSPs in CA1 hippocampal neurons
Krol_2000_J.Comp.Neurol_427_54Absence of p75(NTR) expression reduces nerve growth factor immunolocalization in cholinergic septal neurons
Kronman_2000_J.Biol.Chem_275_29488Hierarchy of post-translational modifications involved in the circulatory longevity of glycoproteins. Demonstration of concerted contributions of glycan sialylation and subunit assembly to the pharmacokinetic behavior of bovine acetylcholinesterase
Kroon_2000_Eur.J.Biochem_267_6740A modular esterase from Penicillium funiculosum which releases ferulic acid from plant cell walls and binds crystalline cellulose contains a carbohydrate binding module
Krovat_2000_Toxicol.Sci_55_352Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells
Krudewig_2000_J.Neurochem_74_1721Distinct internalization of M2 muscarinic acetylcholine receptors confers selective and long-lasting desensitization of signaling to phospholipase C
Kruse_2000_Am.J.Hum.Genet_66_1522The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma
Kryger_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1385Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
Kubo_2000_Brain.Res.Bull_53_275Cholinergic inputs to rostral ventrolateral medulla pressor neurons from hypothalamus
Kucheriavykh_2000_Ross.Fiziol.Zh.Im.I.M.Sechenova_86_1669[Effects of acetylcholine and histamine on leukocyte and neutrophil numbers in the endometrium of rats in various phases of the estrous cycle (by imprints)]
Kudo_2000_J.Pharmacol.Exp.Ther_294_80Phenacetin deacetylase activity in human liver microsomes: distribution, kinetics, and chemical inhibition and stimulation
Kuhl_2000_Ann.Neurol_48_391Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex
Kumagai_2000_Infect.Immun_68_716Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence
Kumar_2000_Biomacromolecules_1_133Candida antartica lipase B catalyzed polycaprolactone synthesis: effects of organic media and temperature
Kumar_2000_Eur.J.Neurol_7_159An efficacy and safety analysis of Exelon in Alzheimer's disease patients with concurrent vascular risk factors
Kumar_2000_J.Org.Chem_65_7800Poly(3-hydroxybutyrate)-depolymerase from Pseudomonas lemoignei: catalysis of esterifications in organic media
Kumura_2000_Clin.Chim.Acta_294_27DX-9065a, a specific factor Xa inhibitor, as a universal anticoagulant for blood collection tubes
Kunzle_2000_Anat.Embryol.(Berl)_202_491The subrhinal paleocortex in the hedgehog tenrec: a multiarchitectonic characterization and an analysis of its connections with the olfactory bulb
Kunzle_2000_Anat.Embryol.(Berl)_202_507Multiarchitectonic characterization of insular, perirhinal and related regions in a basal mammal, Echinops telfairi
Kuo_2000_Mol.Cell.Biochem_214_121Protein nitration
Kuryatov_2000_Eur.J.Pharmacol_393_11Acetylcholine receptor extracellular domain determines sensitivity to nicotine-induced inactivation
Kwak_2000_Lancet_355_2222Relation between cholinesterase inhibitor and Pisa syndrome
Kwan_2000_Zhonghua.Yi.Xue.Za.Zhi.(Taipei)_63_153Coexistence of epilepsy, myasthenia gravis and psoriasis vulgaris
Kwong_2000_Histochem.J_32_521Neurotransmitters, neuropeptides and calcium binding proteins in developing human cerebellum: a review
Lahiri_2000_Acta.Neurol.Scand.Suppl_176_60Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease
Lai_2000_Genome.Res_10_703Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics
Laine_2000_Duodecim_116_1620[Toxic syndromes that accompany poisonings]
Lakritz_2000_Am.J.Vet.Res_61_152Hepatic and pulmonary enzyme activities in horses
Lall_2000_Indian.J.Pediatr_67_583Neonatal Hirschsprung's disease
Lallement_2000_Ann.Pharm.Fr_58_13[Pretreatment of organophosphate poisoning: potential interests of huperzine A]
Lallement_2000_Ann.Pharm.Fr_58_18[Interest in an glutamate antagonistic compound for the treatment of organophosphate poisoning]
Lam_2000_Pharmacol.Toxicol_87_11Four weeks' inhalation exposure of Long Evans rats to 4-tert-butyltoluene: effect on evoked potentials, behaviour, and brain neurochemistry
Lamb_2000_Drug.Metab.Dispos_28_1018Early events in the induction of rat hepatic UDP-glucuronosyltransferases, glutathione S-transferase, and microsomal epoxide hydrolase by 1,7-phenanthroline: comparison with oltipraz, tert-butyl-4-hydroxyanisole, and tert-butylhydroquinone
Lambrecht_2000_Eur.J.Pharmacol_387_R19The novel pyridoxal-5'-phosphate derivative PPNDS potently antagonizes activation of P2X(1) receptors
Lamprea_2000_Behav.Brain.Res_117_97Dissociation of memory and anxiety in a repeated elevated plus maze paradigm: forebrain cholinergic mechanisms
Lanca_2000_Neurosci_96_735The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study
Lanctot_2000_Int.J.Geriatr.Psychiatry_15_338Donepezil for behavioural disorders associated with Lewy bodies: a case series
Landry_2000_Rev.Mal.Respir_17_539[Control of bronchial contractility, regulation of receptor activity and expression]
Langen_2000_Electrophoresis_21_411Two-dimensional map of the proteome of Haemophilus influenzae
Lansdell_2000_Neuropharmacol_39_2604Cloning and heterologous expression of Dalpha4, a Drosophila neuronal nicotinic acetylcholine receptor subunit: identification of an alternative exon influencing the efficiency of subunit assembly
Lansdell_2000_Neuropharmacol_39_671The influence of nicotinic receptor subunit composition upon agonist, alpha-bungarotoxin and insecticide (imidacloprid) binding affinity
Lau_2000_Br.J.Pharmacol_130_1013Cholinergic facilitation of neurotransmission to the smooth muscle of the guinea-pig prostate gland
Lauer_2000_Eur.J.Biochem_267_1698Molecular characterization of two genes from Streptomyces tendae Tu901 required for the formation of the 4-formyl-4-imidazolin-2-one-containing nucleoside moiety of the peptidyl nucleoside antibiotic nikkomycin
Laurin_2000_Mamm.Genome_11_972The hormone-sensitive lipase gene is transcribed from at least five alternative first exons in mouse adipose tissue
Le_2000_Alcohol.Clin.Exp.Res_24_155Involvement of nicotinic receptors in alcohol self-administration
Leckie_2000_Expert.Opin.Investig.Drugs_9_3Novel therapy for COPD
Lee_2000_Am.J.Med.Genet_96_167No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese
Lee_2000_Biosens.Bioelectron_14_795Rapid detection and identification of biological and chemical agents by immunoassay, gene probe assay and enzyme inhibition using a silicon-based biosensor
Lee_2000_J.Biol.Chem_275_35767Acidic amino acids flanking phosphorylation sites in the M2 muscarinic receptor regulate receptor phosphorylation, internalization, and interaction with arrestins
Lee_2000_J.Biol.Chem_275_9284Arrestin binding to the M(2) muscarinic acetylcholine receptor is precluded by an inhibitory element in the third intracellular loop of the receptor
Lee_2000_J.Biomol.Struct.Dyn_18_297Computational studies of essential dynamics of Pseudomonas cepacia lipase
Lee_2000_J.Biosci.Bioeng_90_684Cloning and sequence analysis of the estA gene encoding enzyme for producing (R)-beta-acetylmercaptoisobutyric acid from Pseudomonas aeruginosa 1001
Lee_2000_Med.Vet.Entomol_14_11Biochemical characterization of insecticide resistance in the German cockroach, Blattella germanica, from Malaysia
Lee_2000_Nucl.Med.Biol_27_741Synthesis and biological evaluation of 1-(4-[18F]fluorobenzyl)-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine for in vivo studies of acetylcholinesterase
Lee_2000_Proc.Natl.Acad.Sci.U.S.A_97_6091The complete unique long sequence and the overall genomic organization of the GA strain of Marek's disease virus
Lee_2000_Res.Commun.Mol.Pathol.Pharmacol_108_155Enhanced expression of microsomal epoxide hydrolase and glutathione S-transferase by imidazole correlates with the radioprotective effect
Lee_2000_Xenobiotica_30_1123Effects of flupyrazofos on liver microsomal cytochrome P450 in the male Fischer 344 rat
Lefferts_2000_Food.Addit.Contam_17_511Pesticide residues variability and acute dietary risk assessment: a consumer perspective
Legay_2000_Microsc.Res.Tech_49_56Why so many forms of acetylcholinesterase?
Legendre_2000_J.Neurosci_20_140Recovery from open channel block by acetylcholine during neuromuscular transmission in zebrafish
Lehfeldt_2000_Plant.Cell_12_1295Cloning of the SNG1 gene of Arabidopsis reveals a role for a serine carboxypeptidase-like protein as an acyltransferase in secondary metabolism
Lehmann_2000_Hum.Genet_106_447Association of butyrylcholinesterase K variant with cholinesterase-positive neuritic plaques in the temporal cortex in late-onset Alzheimer's disease
Leibowitz_2000_FEBS.Lett_473_333Activation of PPARdelta alters lipid metabolism in db/db mice
Leiros_2000_J.Auton.Nerv.Syst_79_99Differential activation of nitric oxide synthase through muscarinic acetylcholine receptors in rat salivary glands
Leitinger_2000_J.Comp.Neurol_416_345Cytochemical evidence that acetylcholine is a neurotransmitter of neurons that make excitatory and inhibitory outputs in the locust ocellar visual system
Lenigk_2000_Biosens.Bioelectron_15_541Enzyme biosensor for studying therapeutics of Alzheimer's disease
Leonard_2000_Eur.J.Pharmacol_393_237Smoking and schizophrenia: abnormal nicotinic receptor expression
Lepinard_2000_Prenat.Diagn_20_70Prenatal diagnosis of pyloric atresia-junctional epidermolysis bullosa syndrome in a fetus not known to be at risk
Leposavic_2000_Neuroimmunomodulation_7_59Castration of sexually immature rats affects sympathetic innervation of the adult thymus
Lermontova_2000_Bull.Exp.Biol.Med_129_544Dimebon improves learning in animals with experimental Alzheimer's disease
Lesser_2000_J.Toxicol.Environ.Health_59_57Comparison of oxime-initiated reactivation of organophosphorous-inhibited acetylcholinesterase in brains of avian embryos
Lev-Lehman_2000_J.Mol.Neurosci_14_93Synaptogenesis and myopathy under acetylcholinesterase overexpression
Levandoski_2000_J.Neurochem_74_1279Recombinant expression of alpha-bungarotoxin in Pichia pastoris facilitates identification of mutant toxins engineered to recognize neuronal nicotinic acetylcholine receptors
Leviev_2000_Arterioscler.Thromb.Vasc.Biol_20_516Promoter polymorphisms of human paraoxonase PON1 gene and serum paraoxonase activities and concentrations
Levin_2000_Eur.J.Pharmacol_393_141Development of nicotinic drug therapy for cognitive disorders
Levin_2000_Handb.Exp.Pharmacol_144_587The Role of Nicotinic Acetylcholine Receptors in Cognitive Function
Levy_2000_Neuropsychology_14_288Acetylcholine affects the spatial scale of attention: evidence from Alzheimer's disease
Lewis_2000_Environ.Microbiol_2_407A Pseudomonas stutzeri gene cluster encoding the biosynthesis of the CCl4-dechlorination agent pyridine-2,6-bis(thiocarboxylic acid)
Li_2000_Biochim.Biophys.Acta_1481_237Hyperactivity and interactions of a chimeric myristoryl-ACP thioesterase from the lux system of luminescent bacteria
Li_2000_Dev.Biol_217_394Double-stranded RNA injection produces null phenotypes in zebrafish
Li_2000_J.Neurochem_75_1320Abundant tissue butyrylcholinesterase and its possible function in the acetylcholinesterase knockout mouse
Li_2000_J.Neurosci_20_149Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression
Li_2000_Mol.Med_6_1008Potent induction of apoptosis by beta-lapachone in human multiple myeloma cell lines and patient cells
Li_2000_Neurotoxicol_21_541Muscarinic receptor-mediated pyridostigmine-induced neuronal apoptosis
Li_2000_Pharmacogenet_10_767Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds
Li_2000_Proc.Natl.Acad.Sci.U.S.A_97_6902An acyltransferase catalyzing the formation of diacylglucose is a serine carboxypeptidase-like protein
Li_2000_Sheng.Wu.Hua.Xue.Yu.Sheng.Wu.Wu.Li.Xue.Bao.(Shanghai)_32_183High-efficiency Expression of Prolyl Endopeptidase from Aeromonas punctata subsp. Punctata in Escherichia coli
Liang_2000_J.Biol.Chem_275_24040Importance of arginines 63 and 423 in modulating the bile salt-dependent and bile salt-independent hydrolytic activities of rat carboxyl ester lipase
Liao_2000_Zhongguo.Shi.Yan.Xue.Ye.Xue.Za.Zhi_8_192[Expression of the Cholinesterase-Related Cell Division Controller Gene in Peripheral Blood Cell from Patients with Myelodysplastic Syndrome]
Liebeton_2000_Chem.Biol_7_709Directed evolution of an enantioselective lipase
Lim_2000_Eur.J.Pharmacol_404_353Acetylcholinesterase-independent action of diisopropyl-flurophosphate in the rat aorta
Lin_2000_Bioorg.Med.Chem_8_2601Quantitative structure-activity relationships for the pre-steady-state inhibition of cholesterol esterase by 4-nitrophenyl-N-substituted carbamates
Lin_2000_Br.J.Cancer_82_852Association of CYP1A1 and microsomal epoxide hydrolase polymorphisms with lung squamous cell carcinoma
Lin_2000_Dig.Dis.Sci_45_1517Alterations of GTP-binding proteins (Gsalpha and Gq/11alpha) in gastric smooth muscle cells from streptozotocin-induced and WBN/Kob diabetic rats
Lin_2000_Proc.Natl.Acad.Sci.U.S.A_97_1299Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice
Lindahl_2000_J.Mol.Biol_295_613Identification of related proteins on family, superfamily and fold level
Linderman_2000_Insect.Biochem.Mol.Biol_30_767Inhibition of insect juvenile hormone epoxide hydrolase: asymmetric synthesis and assay of glycidol-ester and epoxy-ester inhibitors of trichoplusia ni epoxide hydrolase
Lindstrom_2000_Handb.Exp.Pharmacol_144_101The Structures of Neuronal Nicotinic Receptors
Lindstrom_2000_Muscle.Nerve_23_453Acetylcholine receptors and myasthenia
Linseman_2000_J.Neurochem_74_2010A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase
Lintern_2000_Neurosci.Lett_284_101Effect of halothane administration on acetylcholinesterase activity in guinea-pig muscle and brain
Lioudyno_2000_Hear.Res_149_167Morphine inhibits an alpha9-acetylcholine nicotinic receptor-mediated response by a mechanism which does not involve opioid receptors
Liu_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_900Expression, purification and preliminary crystallographic studies of a hyperthermophilic esterase from Archaeoglobus fulgidus
Liu_2000_J.Biol.Chem_275_41364Interaction of MyoD family proteins with enhancers of acetylcholine receptor subunit genes in vivo
Liu_2000_J.Econ.Entomol_93_667Amplified esterases B1 and A2-B2 in field populations of Culex pipiens from China
Liu_2000_Neurosci.Lett_282_165Bis(7)-tacrine, a novel acetylcholinesterase inhibitor, reverses AF64A-induced deficits in navigational memory in rats
Liu_2000_Neurotoxicol.Teratol_22_389Effects of cholinesterase inhibitors on a two-component chained schedule performance in rats
Liu_2000_Zhong.Yao.Cai_23_524[Morphological and histological identification and essential oil GC-MS assay of Aralia decaisneana]
Livingston_2000_Int.J.Geriatr.Psychiatry_15_203How useful are cholinesterase inhibitors in the treatment of Alzheimer's disease? A number needed to treat analysis
Lloyd_2000_J.Pharmacol.Exp.Ther_292_461Neuronal nicotinic acetylcholine receptors as novel drug targets
Lluel_2000_Am.J.Physiol.Regul.Integr.Comp.Physiol_278_R964Functional and morphological modifications of the urinary bladder in aging female rats
Lo_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_756Crystallization and preliminary X-ray crystallographic analysis of thioesterase I from Escherichia coli
Lockridge_2000_Neurotoxicol_21_113Pesticides and susceptible populations: people with butyrylcholinesterase genetic variants may be at risk
Loftus_2000_Science_288_2379Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
Lohse_2000_J.Lipid.Res_41_23Compound heterozygosity for a Wolman mutation is frequent among patients with cholesteryl ester storage disease
London_2000_Lung.Cancer_28_147Lung cancer risk in relation to genetic polymorphisms of microsomal epoxide hydrolase among African-Americans and Caucasians in Los Angeles County
Longshaw_2000_Microbiology_146 ( Pt 6)_1419Identification of a second lipase gene, gehD, in Staphylococcus epidermidis: comparison of sequence with those of other staphylococcal lipases
Lopes_2000_Bioorg.Med.Chem_8_707Acyloxymethyl as a drug protecting group. Part 6: N-acyloxymethyl- and N-[(aminocarbonyloxy)methyl]sulfonamides as prodrugs of agents containing a secondary sulfonamide group
Lowe_2000_Biochimie_82_997Properties and function of pancreatic lipase related protein 2
Lu_2000_J.Biol.Chem_275_5682A network of conserved intramolecular contacts defines the off-state of the transmembrane switch mechanism in a seven-transmembrane receptor
Lucinei_2000_Horm.Res_54_186Insulin secretion and acetylcholinesterase activity in monosodium l-glutamate-induced obese mice
Lukomskaya_2000_Neurosci.Behav.Physiol_30_543The involvement of glutamatergic transmission in the mechanism of movement disorders induced by reversive rotation of white mice
Lund_2000_Aquat.Toxicol_48_127The sensitivity of grass shrimp, Palaemonetes pugio, embryos to organophosphate pesticide induced acetylcholinesterase inhibition
Lupardus_2000_J.Physiol_526 Pt 3_527Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP
Lutz_2000_Br.J.Plast.Surg_53_149Selection of donor nerves--an important factor in end-to-side neurorrhaphy
Lutz_2000_Int.J.Occup.Med.Environ.Health_13_215Long-term effects of acute exposure to chlorphenvinphos on behavioural responsiveness to amphetamine and scopolamine in rats
MacKness_2000_Eur.J.Clin.Invest_30_4Paraoxonase activity in two healthy populations with differing rates of coronary heart disease
MacPhee_2000_Biochemistry_39_3433Apolipoprotein C-II39-62 activates lipoprotein lipase by direct lipid-independent binding
Machado_2000_Hum.Pathol_31_3Cardiac autonomic denervation in congestive heart failure: comparison of Chagas' heart disease with other dilated cardiomyopathy
Machard_2000_Antimicrob.Agents.Chemother_44_546A sensitive amphotericin B immunoassay for pharmacokinetic and distribution studies
Machida_2000_Yeast_16_71A 38 kb segment containing the cdc2 gene from the left arm of fission yeast chromosome II: sequence analysis and characterization of the genomic DNA and cDNAs encoded on the segment
Mack_2000_Prog.Neurobiol_60_607The key role of butyrylcholinesterase during neurogenesis and neural disorders: an antisense-5'butyrylcholinesterase-DNA study
Mackness_2000_Biochem.Biophys.Res.Commun_276_729Low paraoxonase in Persian Gulf War Veterans self-reporting Gulf War Syndrome
Mackness_2000_Clin.Sci.(Lond)_98_355Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy
Mae_2000_Xenobiotica_30_565Identification of enzymes responsible for rifalazil metabolism in human liver microsomes
Maelicke_2000_Behav.Brain.Res_113_199Allosterically potentiating ligands of nicotinic receptors as a treatment strategy for Alzheimer's disease
Maelicke_2000_Eur.J.Pharmacol_393_165Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease
Maelicke_2000_Handb.Exp.Pharmacol_144_477Neuronal Nicotinic Acetylcholine Receptors in Non-neuronal Cells, Expression and Renaturation of Ligand Binding Domain, and Modulatory Control by Allosterically Acting Ligands
Maheut-Lourmiere_2000_Neurochirurgie_46_117[Hydrocephalus during pregnancy with or without neurosurgical history in childhood. Practical advice for management]
Malany_2000_Biochemistry_39_15388Orientation of alpha-neurotoxin at the subunit interfaces of the nicotinic acetylcholine receptor
Malik_2000_Fresenius.J.Anal.Chem_367_211Capillary electrophoretic determination of dithiocarbamates and ethyl xanthate
Mallender_2000_Biochemistry_39_7753Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway
Mallouk_2000_Proc.Natl.Acad.Sci.U.S.A_97_4950Elevated subsarcolemmal Ca2+ in mdx mouse skeletal muscle fibers detected with Ca2+-activated K+ channels
Maloney_2000_J.Neurosci_20_4669c-Fos expression in GABAergic, serotonergic, and other neurons of the pontomedullary reticular formation and raphe after paradoxical sleep deprivation and recovery
Manco_2000_Arch.Biochem.Biophys_373_182Cloning, overexpression, and properties of a new thermophilic and thermostable esterase with sequence similarity to hormone-sensitive lipase subfamily from the archaeon Archaeoglobus fulgidus
Manco_2000_Protein.Eng_13_197Homology modeling and identification of serine 160 as nucleophile of the active site in a thermostable carboxylesterase from the archaeon Archaeoglobus fulgidus
Manetti_2000_Biochim.Biophys.Acta_1543_146Design and realization of a tailor-made enzyme to modify the molecular recognition of 2-arylpropionic esters by Candida rugosa lipase
Mang_2000_Br.J.Pharmacol_131_94Modulation of acetylcholine release in the guinea-pig trachea by the nitric oxide donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP)
Manns_2000_J.Neurosci_20_1505Discharge properties of juxtacellularly labeled and immunohistochemically identified cholinergic basal forebrain neurons recorded in association with the electroencephalogram in anesthetized rats
Manns_2000_J.Neurosci_20_9252Discharge profiles of juxtacellularly labeled and immunohistochemically identified GABAergic basal forebrain neurons recorded in association with the electroencephalogram in anesthetized rats
Mansvelder_2000_Neuron_27_349Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Marcel_2000_J.Biol.Chem_275_11603Exploration of the Drosophila acetylcholinesterase substrate activation site using a reversible inhibitor (Triton X-100) and mutated enzymes
Marek_2000_Biochemistry_39_14082Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26
Marenco_2000_Br.J.Pharmacol_129_147Effects of nicotine and chlorisondamine on cerebral glucose utilization in immobilized and freely-moving rats
Marguet_2000_Proc.Natl.Acad.Sci.U.S.A_97_6874Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
Marighetto_2000_Learn.Mem_7_159Further evidence for a dissociation between different forms of mnemonic expressions in a mouse model of age-related cognitive decline: effects of tacrine and S 17092, a novel prolyl endopeptidase inhibitor
Marks_2000_Neuropharmacol_39_2632Nicotinic-agonist stimulated (86)Rb(+) efflux and [(3)H]epibatidine binding of mice differing in beta2 genotype
Marques_2000_Biochem.Biophys.Res.Commun_279_832A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs
Marrs_2000_Food.Addit.Contam_17_487The health significance of pesticide variability in individual commodity items
Marti_2000_Neurologia_15_15[Dementia with Lewy bodies]
Martin-Ruiz_2000_Neuropharmacol_39_2830Alpha and beta nicotinic acetylcholine receptors subunits and synaptophysin in putamen from Parkinson's disease
Martin_2000_Curr.Opin.Neurobiol_10_587Local protein synthesis and its role in synapse-specific plasticity
Martin_2000_J.Pharmacol.Exp.Ther_294_1209Cannabinoid properties of methylfluorophosphonate analogs
Martinez-Ciriano_2000_Histol.Histopathol_15_1093Intrinsic innervation in the intestine of the lizard Podarcis hispanica
Martinez_2000_Biochemistry_39_6979Structural differences in the two agonist binding sites of the Torpedo nicotinic acetylcholine receptor revealed by time-resolved fluorescence spectroscopy
Martinez_2000_Bioorg.Med.Chem_8_731Lipase-catalysed synthesis of new acetylcholinesterase inhibitors: N-benzylpiperidine aminoacid derivatives
Martinez_2000_Eur.J.Med.Chem_35_913N-Benzylpiperidine derivatives of 1,2,4-thiadiazolidinone as new acetylcholinesterase inhibitors
Martos_2000_An.Esp.Pediatr_53_330[High levels of alanine aminotransferase and cholinesterase in obese pre-pubertal children: correlation with basal insulin concentration and anthropometric measures]
Martyn_2000_Anesthesiology_92_31Neuromuscular effects of mivacurium in 2- to 12-yr-old children with burn injury
Marubio_2000_Eur.J.Pharmacol_393_113Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function
Marubio_2000_Handb.Exp.Pharmacol_144_525Knockout Mice as Animal Models for Studying Nicotinic Acetylcholine Receptor Function
Marx_2000_Thromb.Haemost_83_297Characterization of mouse thrombin-activatable fibrinolysis inhibitor
Masaki_2000_Am.J.Physiol.Regul.Integr.Comp.Physiol_279_R1305Impaired response of UCP family to cold exposure in diabetic (db/db) mice
Mason_2000_Hum.Exp.Toxicol_19_511Rates of spontaneous reactivation and aging of acetylcholinesterase in human erythrocytes after inhibition by organophosphorus pesticides
Mason_2000_Occup.Med.(Lond)_50_343The recovery of plasma cholinesterase and erythrocyte acetylcholinesterase activity in workers after over-exposure to dichlorvos
Masunaka_2000_Phytopathology_90_762Distribution and Characterization of AKT Homologs in the Tangerine Pathotype of Alternaria alternata
Masuoka_2000_Rinsho.Ketsueki_41_1226[Recovery from pancytopenia and liver dysfunction after administration of thiamazole for hyperthyroidism]
Materi_2000_Neurosci_97_219Inhibition of synaptically evoked cortical acetylcholine release by adenosine: an in vivo microdialysis study in the rat
Matsuda_2000_Br.J.Pharmacol_130_981Role of loop D of the alpha7 nicotinic acetylcholine receptor in its interaction with the insecticide imidacloprid and related neonicotinoids
Matsuda_2000_Leg.Med.(Tokyo)_2_55Changes in mRNA expression levels of synaptic- and target tissue-specific proteins after organophosphate exposure
Matter_2000_Handb.Exp.Pharmacol_144_33Gene Structure and Transcriptional Regulation of the Neuronal Nicotinic Acetylcholine Receptors
Matthysse_2000_Biochim.Biophys.Acta_1490_208A region of the Agrobacterium tumefaciens chromosome containing genes required for virulence and attachment to host cells
Mattila_2000_J.Med.Genet_37_766Dipeptidyl carboxypeptidase 1 (DCP1) and butyrylcholinesterase (BCHE) gene interactions with the apolipoprotein E epsilon4 allele as risk factors in Alzheimer's disease and in Parkinson's disease with coexisting Alzheimer pathology
Mattsson_2000_Toxicol.Sci_53_438Lack of differential sensitivity to cholinesterase inhibition in fetuses and neonates compared to dams treated perinatally with chlorpyrifos
Maugard_2000_Biotechnol.Prog_16_358Study of vitamin ester synthesis by lipase-catalyzed transesterification in organic media
Maurissen_2000_Neurotoxicol.Teratol_22_237Chlorpyrifos: lack of cognitive effects in adult Long-Evans rats
Mazurek_2000_N.Engl.J.Med_342_821Treatment of Alzheimer's disease [letter]
McCallum_2000_Psychopharmacology.(Berl)_150_1Mecamylamine prevents tolerance but enhances whole brain [3H]epibatidine binding in response to repeated nicotine administration in rats
McCarroll_2000_Nature_407_961Insecticides and mosquito-borne disease
McConkey_2000_Anaesth.Intensive.Care_28_82Congenital myasthenic syndrome: a rare, potentially treatable cause of respiratory failure in a floppy infant
McGaughy_2000_Behav.Brain.Res_115_251The role of cortical cholinergic afferent projections in cognition: impact of new selective immunotoxins
McGehee_2000_Anesthesiology_93_510Cholinesterase inhibition by potato glycoalkaloids slows mivacurium metabolism
McGirr_2000_Ulster.Med.J_69_123Drugs for dementia: the first year. An audit of prescribing practice
McGrath_2000_Cochrane.Database.Syst.Rev__CD000207Cholinergic medication for neuroleptic-induced tardive dyskinesia
McIlroy_2000_J.Med.Genet_37_182Butyrylcholinesterase K variant is genetically associated with late onset Alzheimer's disease in Northern Ireland
McIntosh_2000_Eur.J.Pharmacol_393_205Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function
McIntosh_2000_Handb.Exp.Pharmacol_144_Toxin Antagonists of the Neuronal Nicotinic Acetylcholine Receptor
McKeand_2000_Parasitol_120 Suppl_S17Vaccine development and diagnostics of Dictyocaulus viviparus
McKeith_2000_Int.J.Geriatr.Psychiatry_15_387Rivastigmine in the treatment of dementia with Lewy bodies: preliminary findings from an open trial
McKeith_2000_Lancet_356_2031Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study
McNeel_2000_J.Anim.Sci_78_934Effect of feed restriction on adipose tissue transcript concentrations in genetically lean and obese pigs
McNeel_2000_J.Nutr.Biochem_11_139Nutritional deprivation reduces the transcripts for transcription factors and adipocyte-characteristic proteins in porcine adipocytes(1)
Mediavilla_2000_Mol.Microbiol_38_955Genome organization and characterization of mycobacteriophage Bxb1
Mega_2000_Int.J.Neuropsychopharmacol_3_3The cholinergic deficit in Alzheimer's disease: impact on cognition, behaviour and function
Mega_2000_J.Neuropsychiatry.Clin.Neurosci_12_209Orbital and dorsolateral frontal perfusion defect associated with behavioral response to cholinesterase inhibitor therapy in Alzheimer's disease
Meier-Ruge_2000_Pediatr.Surg.Int_16_2Histopathologic observations of anorectal abnormalities in anal atresia
Melnikova_2000_Eur.J.Pharmacol_393_75Interactions between regulatory proteins that bind to the nicotinic receptor beta4 subunit gene promoter
Melo_2000_Chem.Phys.Lipids_106_181Dynamic light scattering of cutinase in AOT reverse micelles
Melter_2000_Am.J.Gastroenterol_95_3522Progressive familial intrahepatic cholestasis: partial biliary diversion normalizes serum lipids and improves growth in noncirrhotic patients
Messer_2000_Pharm.Acta.Helv_74_135Design and development of selective muscarinic agonists for the treatment of Alzheimer's disease: characterization of tetrahydropyrimidine derivatives and development of new approaches for improved affinity and selectivity for M1 receptors
Meuret_2000_Anesthesiology_93_708Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers
Meurs_2000_Br.J.Pharmacol_130_1793Modulation of cholinergic airway reactivity and nitric oxide production by endogenous arginase activity
Meyer_2000_Eur.J.Pharmacol_393_171The identification of novel structural compound classes exhibiting high affinity for neuronal nicotinic acetylcholine receptors and analgesic efficacy in preclinical models of pain
Meyer_2000_Keio.J.Med_49 Suppl 1_A95XE-CT CBF changes during normative aging, cognitive decline and dementia
Michalet_2000_J.Biol.Chem_275_25608Relative spatial position of a snake neurotoxin and the reduced disulfide bond alpha (Cys192-Cys193) at the alpha gamma interface of the nicotinic acetylcholine receptor
Michaux_2000_Mol.Phylogenet.Evol_17_280The Bushlike Radiation of Muroid Rodents Is Exemplified by the Molecular Phylogeny of the LCAT Nuclear Gene
Micic_2000_J.Alzheimers.Dis_2_1Acetylcholinesterase Activity in the Mongolian Gerbil Brain after Acute Poisoning with Aluminum
Mike_2000_Brain.Res_873_112Ca(2+)-sensitive inhibition by Pb(2+) of alpha7-containing nicotinic acetylcholine receptors in hippocampal neurons
Mike_2000_Brain.Res_882_155Choline and acetylcholine have similar kinetic properties of activation and desensitization on the alpha7 nicotinic receptors in rat hippocampal neurons
Milan_2000_J.Comp.Neurol_419_96Patterns of calretinin, calbindin, and tyrosine-hydroxylase expression are consistent with the prosomeric map of the frog diencephalon
Milatovic_2000_Free.Radic.Biol.Med_28_597Atypical effect of some spin trapping agents: reversible inhibition of acetylcholinesterase
Milatovic_2000_Neurosci.Lett_278_25Spin trapping agent phenyl-N-tert-butylnitrone prevents diisopropylphosphorofluoridate-induced excitotoxicity in skeletal muscle of the rat
Miled_2000_Biochim.Biophys.Acta_1476_165A conformational transition between an open and closed form of human pancreatic lipase revealed by a monoclonal antibody
Miled_2000_Biochimie_82_973Digestive lipases: from three-dimensional structure to physiology
Miller_2000_Neuropharmacol_39_2654Lobeline inhibits nicotine-evoked [(3)H]dopamine overflow from rat striatal slices and nicotine-evoked (86)Rb(+) efflux from thalamic synaptosomes
Mills_2000_J.Urol_163_646Studies of the pathophysiology of idiopathic detrusor instability: the physiological properties of the detrusor smooth muscle and its pattern of innervation
Mine_2000_J.Biosci.Bioeng_90_631Preparation of detergent-lipase complexes utilizing water-soluble amphiphiles in single aqueous phase and catalysis of transesterifications in homogeneous organic solvents
Minier_2000_Mar.Environ.Res_50_373Flounder health status in the Seine Bay. A multibiomarker study
Miranda_2000_Prog.Neurobiol_62_633The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease
Mirza_2000_Psychopharmacology.(Berl)_148_243The role of nicotinic and muscarinic acetylcholine receptors in attention
Mishima_2000_Jpn.J.Pharmacol_84_163The scopolamine-induced impairment of spatial cognition parallels the acetylcholine release in the ventral hippocampus in rats
Miura_2000_Appl.Environ.Microbiol_66_4883Screening of genes involved in isooctane tolerance in Saccharomyces cerevisiae by using mRNA differential display
Miyazaki_2000_J.Polym.Environ_8_175Properties of a Poly(3-hydroxybutyrate) Depolymerase from Penicillium funiculosum
Miyazawa_2000_Hematol_5_233Megakaryocytic Maturation is Regulated by Maintaining a Balance Against Cytokine Induced-cell Proliferation: Steel Factor Retards Thrombopoietin-induced Megakaryocytic Differentiation While Synergistically Stimulating Mitogenesis; Hematopoiesis
Miyo_2000_Genes.Genet.Syst_75_97Seasonal fluctuation in susceptibility to insecticides within natural populations of Drosophila melanogaster: empirical observations of fitness costs of insecticide resistance
Mizuno_2000_Epilepsy.Res_40_187Effects of carbamazepine on acetylcholine release and metabolism
Moennig_2000_Atherosclerosis_149_395Detection of missense mutations in the genes for lipoprotein lipase and hepatic triglyceride lipase in patients with dyslipidemia undergoing coronary angiography
Mohsin_2000_Biotechnol.Bioeng_69_591Use of ion chromatography-electrospray mass spectrometry for the determination of ionic compounds in agricultural chemicals
Molgaard_2000_Structure.Fold.Des_8_373Rhamnogalacturonan acetylesterase elucidates the structure and function of a new family of hydrolases
Molnar_2000_Chem.Biol_7_97The biosynthetic gene cluster for the microtubule-stabilizing agents epothilones A and B from Sorangium cellulosum So ce90
Monnet-Tschudi_2000_Toxicol.Appl.Pharmacol_165_175Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures
Monserrat_2000_Environ.Toxicol.Pharmacol_9_39Methodological and biological aspects to be considered in acetylcholinesterase reactivation assays using 2-PAM
Montero_2000_Exp.Nephrol_8_258Reciprocal regulation of LTA(4) hydrolase expression in human monocytes by gamma-interferon and interleukins 4 and 13: potential relevance to leukotriene regulation in glomerular disease
Moon_2000_Bioorg.Med.Chem.Lett_10_1435Synthesis of tetrakis(multifluoro-4-pyridyl)porphin derivatives as acetylcholinesterase inhibitors
Mora_2000_Ecotoxicol.Environ.Saf_46_234Relationship between toxicokinetics of carbaryl and effect on acetylcholinesterase activity in Pomacea patula snail
Morain_2000_Br.J.Clin.Pharmacol_50_350Pharmacodynamic and pharmacokinetic profile of S 17092, a new orally active prolyl endopeptidase inhibitor, in elderly healthy volunteers. A phase I study
Moralev_2000_Dokl.Biochem_373_156Variability of the structure of the cholinesterase active center as studied by factor analysis
Moralev_2000_Dokl.Biochem_375_215New data on the structure of the acyl pocket in cholinesterases
Morel_2000_J.Biol.Chem_275_7304Comparative expression of homologous proteins. A novel mode of transcriptional regulation by the coding sequence folding compatibility of chimeras
Moretto_2000_Arch.Toxicol_73_655The relevance of inhibitor-substrate interactions when measuring neuropathy target esterase inhibition
Mori_2000_Clin.Biochem_33_323Improved method for direct DNA sequencing of the human lipoprotein lipase gene using an auto DNA sequencer
Mori_2000_Nihon.Ronen.Igakkai.Zasshi_37_772[Dementia with Lewy bodies]
Morisseau_2000_Arch.Biochem.Biophys_378_321Cress and potato soluble epoxide hydrolases: purification, biochemical characterization, and comparison to mammalian enzymes
Morley_2000_Hear.Res_147_104Cholinergic receptors: dual roles in transduction and plasticity
Morton_2000_Cancer.Res_60_4206Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase
Morton_2000_Mol.Biotechnol_16_193Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase
Moser_2000_Neurotoxicol.Teratol_22_713Dose-response and time-course of neurobehavioral changes following oral chlorpyrifos in rats of different ages
Motamed_2000_Anesth.Analg_91_732The mechanism of pancuronium potentiation of mivacurium block: use of the isolated-arm technique
Mourier_2000_Protein.Eng_13_217Chemical engineering of a three-fingered toxin with anti-alpha7 neuronal acetylcholine receptor activity
Moussou_2000_Enzyme.Microb.Technol_26_414Clues for the existence of two different epoxide hydrolase activities in the fungus Beauveria bassiana
Moya_2000_Eur.J.Endocrinol_143_789Genomic organization of the 5' region of the human thyroglobulin gene
Mu_2000_Anat.Rec_260_308Neuromuscular specializations of the pharyngeal dilator muscles: II. Compartmentalization of the canine genioglossus muscle
Mufson_2000_Neuropharmacol_39_1404Galanin receptor plasticity within the nucleus basalis in early and late Alzheimer's disease: an in vitro autoradiographic analysis
Mukhin_2000_Mol.Pharmacol_57_6425-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors
Mukhtarov_2000_Ross.Fiziol.Zh.Im.I.M.Sechenova_86_335[Modulation of the intensity of the non-quantal transmitter release by nitric oxide (NO) at the neuromuscular junction]
Mullaney_2000_Ophthalmology_107_504The natural history and ophthalmic involvement in childhood myasthenia gravis at the hospital for sick children
Mullins_2000_Mayo.Clin.Proc_75_871Physostigmine treatment of gamma-hydroxybutyric acid overdose: appropriate or inappropriate use of a reversal agent?
Mundt-Petersen_2000_Exp.Neurol_164_112Caspase inhibition increases embryonic striatal graft survival
Murakami_2000_Behav.Brain.Res_109_83Ameliorative effect of tacrine on spatial memory deficit in chronic two-vessel occluded rats is reversible and mediated by muscarinic M1 receptor stimulation
Murthy_2000_Am.J.Physiol.Cell.Physiol_279_C925Heterologous desensitization of response mediated by selective PKC-dependent phosphorylation of G(i-1) and G(i-2)
Murthy_2000_J.Biol.Chem_275_30211Heterologous desensitization mediated by G protein-specific binding to caveolin
Mushiroda_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_126_225The house musk shrew (Suncus murinus): a unique animal with extremely low level of expression of mRNAs for CYP3A and flavin-containing monooxygenase
Myers_2000_Science_287_2196A whole-genome assembly of Drosophila
Nachmansohn_2000_Yale.J.Biol.Med_73_241On the physiological significance of choline esterase. 1939
Nagao_2000_J.Biosci.Bioeng_89_446Amino acid residues contributing to stabilization of Fusarium heterosporum lipase
Nagase_2000_DNA.Res_7_143Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
Nagase_2000_DNA.Res_7_65Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro
Nagy_2000_Proc.Natl.Acad.Sci.U.S.A_97_829Stability of cytotoxic luteinizing hormone-releasing hormone conjugate (AN-152) containing doxorubicin 14-O-hemiglutarate in mouse and human serum in vitro: implications for the design of preclinical studies
Nagymajtenyi_2000_Cent.Eur.J.Public.Health_8 Suppl_64Experimentally induced functional changes of the nervous system caused by subchronic combined administration of heavy metals and an organophosphate pesticide
Nakagawa_2000_Bioorg.Med.Chem_8_26633-D QSAR analysis of inhibition of murine soluble epoxide hydrolase (MsEH) by benzoylureas, arylureas, and their analogues
Nakagawa_2000_Org.Lett_2_953A concise synthesis of physostigmine from skatole and activated aziridine via alkylative cyclization
Nakagawasai_2000_Brain.Res.Bull_52_189Immunohistochemical estimation of brain choline acetyltransferase and somatostatin related to the impairment of avoidance learning induced by thiamine deficiency
Nakajima_2000_J.Biosci.Bioeng_90_347Regioselective acylation of flavonoid glucoside with aromatic acid by an enzymatic reaction system from cultured cells of Ipomoea batatas
Nakajima_2000_J.Chem.Neuroanat_18_31Immunohistochemical demonstration of choline acetyltransferase of a peripheral type (pChAT) in the enteric nervous system of rats
Nakazato_2000_Life.Sci_67_1139Cholinergic and glutamatergic activation reverses working memory failure by hippocampal histamine H1 receptor blockade in rats
Namekata_2000_Surg.Today_30_403Significant changes in the serum levels of IL-6, h-HGF, and type IV collagen 7S during the perioperative period of a hepatectomy: relevance to SIRS
Napoli_2000_Minerva.Gastroenterol.Dietol_46_73Evolution of acute pancreatitis in diabetes mellitus
Narahashi_2000_Toxicol.Sci_57_193Symposium overview: mechanism of action of nicotine on neuronal acetylcholine receptors, from molecule to behavior
Nardini_2000_J.Biol.Chem_275_31219Crystal structure of pseudomonas aeruginosa lipase in the open conformation. The prototype for family I.1 of bacterial lipases
Naruse_2000_Genetics_154_1773A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution
Nasman_2000_Biochem.Biophys.Res.Commun_271_435Recombinant expression of a selective blocker of M(1) muscarinic receptors
Nassar_2000_J.Egypt.Soc.Parasitol_30_631Assessment of two natural marine toxins (Microcystis aeruginosa and Parasicyonis actinostoloides) for the control of some medical and agriculture insects with reference to the action on mice
Nathanson_2000_Proc.Natl.Acad.Sci.U.S.A_97_6245A multiplicity of muscarinic mechanisms: enough signaling pathways to take your breath away
Navab_2000_J.Lipid.Res_41_1495Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3
Navaratnam_2000_J.Neurochem_74_2146Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization
Nawani_2000_Mol.Cell.Biochem_206_91Purification, characterization and thermostability of lipase from a thermophilic Bacillus sp. J33
Nayak_2000_Neuropharmacol_39_2681Nicotinic receptors co-localize with 5-HT(3) serotonin receptors on striatal nerve terminals
Neumann_2000_Bioelectrochemistry_52_43Digression on chemical electromagnetic field effects in membrane signal transduction--cooperativity paradigm of the acetylcholine receptor
Newhouse_2000_Handb.Exp.Pharmacol_144_779Clinical Aspects of Nicotinic Agents: Therapeutic Applications in Central Nervous System Disorders
Newhouse_2000_Pharm.Acta.Helv_74_91Nicotinic systems in central nervous systems disease: degenerative disorders and beyond
Ng_2000_Proc.Natl.Acad.Sci.U.S.A_97_12176Genome sequence of Halobacterium species NRC-1
Nguyen_2000_Am.J.Pathol_157_1377Novel human alpha9 acetylcholine receptor regulating keratinocyte adhesion is targeted by Pemphigus vulgaris autoimmunity
Nguyen_2000_Development_127_1209Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway
Nguyen_2000_J.Biol.Chem_275_29466Pemphigus vulgaris antibody identifies pemphaxin. A novel keratinocyte annexin-like molecule binding acetylcholine
Nguyen_2000_J.Clin.Invest_106_1467Antibodies against keratinocyte antigens other than desmogleins 1 and 3 can induce pemphigus vulgaris-like lesions
Nguyen_2000_J.Dent.Res_79_939Choline acetyltransferase, acetylcholinesterase, and nicotinic acetylcholine receptors of human gingival and esophageal epithelia
Nguyen_2000_Learn.Mem_7_170Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice
Nicklas_2000_Hum.Genet_106_420Lipoprotein lipase gene variation is associated with adipose tissue lipoprotein lipase activity, and lipoprotein lipid and glucose concentrations in overweight postmenopausal women
Niesen_2000_Neurology_54_1873Pyridostigmine-induced microcephaly
Nigg_2000_Rev.Environ.Contam.Toxicol_163_29Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure
Nimmrich_2000_Cancer.Lett_160_37Seven genes that are differentially transcribed in colorectal tumor cell lines
Niranjan_2000_Mol.Cell.Biochem_204_57Membrane changes in rat erythrocyte ghosts on ghee feeding
Nishimune_2000_Nat.Cell.Biol_2_906Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway
Nishimura_2000_J.Biosci.Bioeng_90_564Inhibitory effects of carbohydrates on cholesterol esterase biosynthesis in Streptomyces lavendulae H646-SY2
Nistiar_2000_Folia.Microbiol.(Praha)_45_567Influence of intoxication with organophosphates on rumen bacteria and rumen protozoa and protective effect of clinoptilolite-rich zeolite on bacterial and protozoan concentration in rumen
Nitsch_2000_Ann.Neurol_48_913The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease
Nomura_2000_Pestic.Biochem.Physiol_66_73The Genotype and Heredity of Modified Acetylcholinesterase of the Green Rice Leafhopper (Nephotettix cincticeps Uhler)
Nordberg_2000_Handb.Exp.Pharmacol_144_539Noninvasive Exploration of Nicotinic Acetylcholine Receptors In Vivo
Nordberg_2000_Neurotox.Res_2_157Neuroprotection in Alzheimer's disease - new strategies for treatment
Novak_2000_Neurochem.Res_25_561Regulation of Myo-inositol homeostasis in differentiated human NT2-N neurons
Novitskii_2000_Dokl.Biochem_371_57Acetylcholine content and the localization of acetylcholine esterase activity in different tissues of magnetic-orientation types of radish
Nunes-Tavares_2000_An.Acad.Bras.Cienc_72_331Choline acetyltransferase detection in normal and denervated electrocyte from Electrophorus electricus (L.) using a confocal scanning optical microscopy analysis
Nussbaumer_2000_Insect.Biochem.Mol.Biol_30_307Isolation and characterization of juvenile hormone esterase from hemolymph of Lymantria dispar by affinity- and by anion-exchange chromatography
O'Hara_2000_West.J.Med_172_115Update on Alzheimer's disease: recent findings and treatments
O'Rourke_2000_J.Expo.Anal.Environ.Epidemiol_10_672Pesticide exposure and creatinine variation among young children
Oakeshott_2000_Genetica_110_231An episode of accelerated amino acid change in Drosophila esterase-6 associated with a change in physiological function
Oates_2000_Dev.Biol_224_20Too much interference: injection of double-stranded RNA has nonspecific effects in the zebrafish embryo
Obata_2000_Bioorg.Med.Chem.Lett_10_1315Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor
Ocampo_2000_J.Am.Mosq.Control.Assoc_16_331Insecticide susceptibility in Anopheles pseudopunctipennis from Colombia: comparison between bioassays and biochemical assays
Oelkers_2000_J.Biol.Chem_275_15609A lecithin cholesterol acyltransferase-like gene mediates diacylglycerol esterification in yeast
Oesch_2000_Toxicol.Pathol_28_382Metabolic detoxification: implications for thresholds
Ogino_2000_J.Biosci.Bioeng_89_451Purification and characterization of organic solvent-stable lipase from organic solvent-tolerant Pseudomonas aeruginosa LST-03
Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_609Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro
Ogura_2000_Methods.Find.Exp.Clin.Pharmacol_22_89Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats
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Oh_2000_Brain.Res_853_174Overexpression of neurotrophin receptor p75 contributes to the excitotoxin-induced cholinergic neuronal death in rat basal forebrain
Ohayo-Mitoko_2000_Occup.Environ.Med_57_195Self reported symptoms and inhibition of acetylcholinesterase activity among Kenyan agricultural workers
Ohba_2000_Jpn.J.Ophthalmol_44_320Introduction to genetics in ophthalmology, value of family studies
Ohi_2000_Scand.J.Gastroenterol_35_413Tissue concentration of platelet-derived endothelial cell growth factor in colorectal cancer
Ohnishi_2000_Syst.Appl.Microbiol_23_315Comparative analysis of the whole set of rRNA operons between an enterohemorrhagic Escherichia coli O157:H7 Sakai strain and an Escherichia coli K-12 strain MG1655
Ohno_2000_Ann.Neurol_47_162The spectrum of mutations causing end-plate acetylcholinesterase deficiency
Ohtsubo_2000_Gene_256_223Expression of the bph genes involved in biphenyl/PCB degradation in Pseudomonas sp. KKS102 induced by the biphenyl degradation intermediate, 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
Okumura_2000_Brain.Dev_22 Suppl 1_S27The cat neostriatum: relative distribution of cholinergic neurons versus serotonergic fibers
Olianas_2000_Br.J.Pharmacol_131_447Inhibition of acetylcholine muscarinic M(1) receptor function by the M(1)-selective ligand muscarinic toxin 7 (MT-7)
Oliveira-Lima_2000_Cad.Saude.Publica_16 Suppl 2_75[Peridomiciliary changes and implications for Triatoma brasiliensis control]
Oliveira-Silva_2000_Hum.Exp.Toxicol_19_173Cholinesterase activities determination in frozen blood samples: an improvement to the occupational monitoring in developing countries
Oliveira_2000_Cad.Saude.Publica_16 Suppl 2_105[Focal and total residual insecticide spraying to control Triatoma brasiliensis and Triatoma pseudomaculata in Northeast Brazil]
Omi_2000_Anim.Genet_31_413Molecular basis of esterase D polymorphism in the pig
Omiecinski_2000_Toxicol.Lett_112-113_365Epoxide hydrolase--polymorphism and role in toxicology
Orr-Urtreger_2000_J.Neurochem_74_2154Mice homozygous for the L250T mutation in the alpha7 nicotinic acetylcholine receptor show increased neuronal apoptosis and die within 1 day of birth
Osaka_2000_J.Biol.Chem_275_5478Pairwise electrostatic interactions between alpha-neurotoxins and gamma, delta, and epsilon subunits of the nicotinic acetylcholine receptor
Osman_2000_J.Egypt.Public.Health.Assoc_75_301Effect of the carbamate aldicarb on acetyl cholinesterase extracted from whole and different parts of rat brain (in vitro and in vivo studies)
Ostergaard_2000_Anesthesiology_92_1581The influence of drug-induced low plasma cholinesterase activity on the pharmacokinetics and pharmacodynamics of mivacurium
Osuga_2000_Proc.Natl.Acad.Sci.U.S.A_97_787Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
Otoguro_2000_J.Antibiot.(Tokyo)_53_50Arisugacins C and D, novel acetylcholinesterase inhibitors and their related novel metabolites produced by Penicilium sp. FO-4259-11
Ottea_2000_Pestic.Biochem.Physiol_66_20Mechanisms of Pyrethroid Resistance in Larvae and Adults from a Cypermethrin-Selected Strain of Heliothis virescens (F.)
Oue_2000_Pediatr.Surg.Int_16_267Muscarinic acetylcholine receptor expression in aganglionic bowel
Overstreet_2000_Neurotoxicol_21_75Organophosphate pesticides, cholinergic function and cognitive performance in advanced age
Owen_2000_Anesthesiology_92_361Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia
Paas_2000_Trends.Pharmacol.Sci_21_87How well can molecular modelling predict the crystal structure: the case of the ligand-binding domain of glutamate receptors
Pachaly_2000_Pharmazie_55_777[Angelicastigmin, a new eserine alkaloid from Angelica polymorpha]
Packard_2000_N.Engl.J.Med_343_1148Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study Group
Padilla_2000_Neurotoxicol_21_49Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophos
Padmanabhan_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1479Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B
Paiva_2000_Enzyme.Microb.Technol_27_187Kinetics and mechanisms of reactions catalyzed by immobilized lipases*
Pakaski_2000_Brain.Res_863_266In vitro effects of metrifonate on neuronal amyloid precursor protein processing and protein kinase C level
Pan_2000_Acta.Pharmacol.Sin_21_124Learning deficits induced by 4 belladonna alkaloids are preferentially attenuated by tacrine
Pandit_2000_J.Biol.Chem_275_30610Crystal structure of human squalene synthase. A key enzyme in cholesterol biosynthesis
Papanastasiou_2000_J.Neuroimmunol_104_124Prevention of passively transferred experimental autoimmune myasthenia gravis by Fab fragments of monoclonal antibodies directed against the main immunogenic region of the acetylcholine receptor
Papke_2000_Eur.J.Pharmacol_393_179alpha7 receptor-selective agonists and modes of alpha7 receptor activation
Parisi_2000_Pediatr.Neurol_23_185A female with central anticholinergic syndrome responsive to neostigmine
Park_2000_Biochem.Biophys.Res.Commun_276_321Hypoxia induces the expression of a 43-kDa protein (PROXY-1) in normal and malignant cells
Park_2000_J.Microbiol_38_275Cloning and Sequence Analysis of the xylL Gene Responsible for 4CBA-Dihydrodiol Dehydrogenase from Pseudomonas sp. S-47.
Park_2000_J.Reconstr.Microsurg_16_135Direct muscle neurotization in rat soleus muscle
Parker_2000_Arch.Environ.Contam.Toxicol_39_233Differential toxicities of organophosphate and carbamate insecticides in the nestling European starling (Sturnus vulgaris)
Parkhill_2000_Nature_403_665The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences
Parkhill_2000_Nature_404_502Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
Parkhomovskiy_2000_Biochem.Biophys.Res.Commun_270_899Alpha-galactosidase stimulates acetylcholine receptor aggregation in skeletal muscle cells via PNA-binding carbohydrates
Parkhomovskiy_2000_Mol.Cell.Neurosci_15_380N-acetyllactosamine and the CT carbohydrate antigen mediate agrin-dependent activation of MuSK and acetylcholine receptor clustering in skeletal muscle
Parnetti_2000_J.Neurol_247_163Therapeutic options in dementia
Parsons_2000_FASEB.J_14_2423Transport mechanisms in acetylcholine and monoamine storage
Passetti_2000_Eur.J.Neurosci_12_3051Increased acetylcholine release in the rat medial prefrontal cortex during performance of a visual attentional task
Paterson_2000_Prog.Neurobiol_61_75Neuronal nicotinic receptors in the human brain
Patterson_2000_Cell.Death.Differ_7_137Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition
Pautas_2000_Presse.Med_29_835[Myasthenia in the aged: a case with unusually late onset]
Pauza_2000_Anat.Rec_259_353Morphology, distribution, and variability of the epicardiac neural ganglionated subplexuses in the human heart
Pavia_2000_Neurosci.Lett_278_69Repeated intracerebroventricular administration of beta-amyloid(25-35) to rats decreases muscarinic receptors in cerebral cortex
Pawlik_2000_Mol.Ther_1_457Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11
Paysan_2000_J.Comp.Neurol_425_284The neurofilament infrastructure of a developing presynaptic calyx
Pearl_2000_Biochem.Soc.Trans_28_269Using the CATH domain database to assign structures and functions to the genome sequences
Peinado-Onsurbe_2000_Biol.Neonat_77_131Effect of fasting on hepatic lipase activity in the liver of developing rats
Pemberton_2000_Pflugers.Arch_440_452Modulation of low-threshold T-type calcium channels by the five muscarinic receptor subtypes in NIH 3T3 cells
Pennefather_2000_J.Auton.Pharmacol_20_193The autonomic and sensory innervation of the smooth muscle of the prostate gland: a review of pharmacological and histological studies
Penning_2000_J.Med.Chem_43_721Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase
Perez-Mendoza_2000_J.Econ.Entomol_93_31Alterations in esterases are associated with malathion resistance in Habrobracon hebetor (Hymenoptera: Braconidae)
Perkins_2000_Toxicol.Sci_53_308In vivo acetylcholinesterase inhibition, metabolism, and toxicokinetics of aldicarb in channel catfish: role of biotransformation in acute toxicity
Perrier_2000_J.Biol.Chem_275_34260Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface
Perrier_2000_J.Neurophysiol_83_3201Cooperation of muscle and cutaneous afferents in the feedback of contraction to peroneal motoneurons
Perrier_2000_J.Neurophysiol_83_3209Effects on peroneal motoneurons of cutaneous afferents activated by mechanical or electrical stimulations
Perry_2000_Eur.J.Pharmacol_393_215Nicotinic receptor subtypes in human brain ageing, Alzheimer and Lewy body diseases
Perry_2000_J.Pharm.Pharmacol_52_895In-vitro inhibition of human erythrocyte acetylcholinesterase by salvia lavandulaefolia essential oil and constituent terpenes
Peruzzi_2000_Ann.N.Y.Acad.Sci_903_394Differentiated cerebrovascular effects of physostigmine and tacrine in cortical areas deafferented from the nucleus basalis magnocellularis suggest involvement of basalocortical projections to microvessels
Petit_2000_Br.J.Pharmacol_130_1613Novel proline endopeptidase inhibitors do not modify Abeta40/42 formation and degradation by human cells expressing wild-type and swedish mutated beta-amyloid precursor protein
Petroianu_2000_J.Appl.Toxicol_20_249L-lactate protects in vitro acetylcholinesterase (AChE) from inhibition by paraoxon (E 600)
Petrovic_2000_Pharmazie_55_454The treatment of delayed polyneuropathy induced by diisopropylfluorophosphate in hens
Pfaffendorf_2000_J.Auton.Pharmacol_20_55Probing the selectivity of allosteric modulators of muscarinic receptors at other G-protein-coupled receptors
Philibert_2000_Gene_246_303The structure and expression of the human neuroligin-3 gene
Philippens_2000_Pharmacol.Biochem.Behav_65_175Scopolamine augments the efficacy of physostigmine against soman poisoning in guinea pigs
Philippens_2000_Toxicol.Sci_53_84Subchronic physostigmine pretreatment in marmosets: absence of side effects and effectiveness against soman poisoning with negligible postintoxication incapacitation
Piasecka_2000_Scand.J.Clin.Lab.Invest_60_395Effect of combined treatment with perindoprilat and low-power red light laser irradiation on human erythrocyte membrane fluidity, membrane potential and acetylcholinesterase activity
Picciotto_2000_Neuropsychopharmacology_22_451Nicotinic receptors in the brain. Links between molecular biology and behavior
Pignede_2000_J.Bacteriol_182_2802Characterization of an extracellular lipase encoded by LIP2 in yarrowia lipolytica
Pignol_2000_J.Biol.Chem_275_4220Critical role of micelles in pancreatic lipase activation revealed by small angle neutron scattering
Pihlajamaki_2000_Arterioscler.Thromb.Vasc.Biol_20_1789G-250A substitution in promoter of hepatic lipase gene is associated with dyslipidemia and insulin resistance in healthy control subjects and in members of families with familial combined hyperlipidemia
Pilon_2000_Mol.Biol.Cell_11_3277The diabetes autoantigen ICA69 and its Caenorhabditis elegans homologue, ric-19, are conserved regulators of neuroendocrine secretion
Pinot_2000_Biochem.Soc.Trans_28_867omega-Hydroxylation of epoxy- and hydroxy-fatty acids by CYP94A1: possible involvement in plant defence
Pitts_2000_Br.J.Anaesth_85_592Determination of succinylcholine in plasma by high-pressure liquid chromatography with electrochemical detection
Plataras_2000_Clin.Biochem_33_351Effect of CDP-choline on brain acetylcholinesterase and Na(+), K(+)-ATPase in adult rats
Platteborze_2000_Biotechnol.Appl.Biochem_31 ( Pt 3)_225Expression of biologically active human butyrylcholinesterase in the cabbage looper (Trichoplusia ni)
Pluth_2000_Mutat.Res_465_101Role of maternal exposures and newborn genotypes on newborn chromosome aberration frequencies
Pluth_2000_Pharmacogenet_10_311The relationship between genotype and chromosome aberration frequencies in a normal adult population
Podol'skii_2000_Zh.Vyssh.Nerv.Deiat.Im.I.P.Pavlova_50_982[Long-term changes in EEG spectra of the hippocampus and neocortex during pharmacological action on the cholinergic system]
Poelarends_2000_J.Bacteriol_182_2191Roles of horizontal gene transfer and gene integration in evolution of 1,3-dichloropropene- and 1,2-dibromoethane-degradative pathways
Pogun_2000_Eur.Neuropsychopharmacol_10_463Nicotine modulates nitric oxide in rat brain
Popke_2000_Pharmacol.Biochem.Behav_67_377Comparison of drug effects on the performance of two timing tasks in rats
Potter_2000_Mol.Biotechnol_15_105Construction of adenovirus for high level expression of small RNAs in mammalian cells. Application to a Bcl-2 ribozyme
Pouch_2000_Mol.Microbiol_35_368Characterization of the 20S proteasome from the actinomycete Frankia
Pouille_2000_J.Physiol_527 Pt 2_265Dendro-somatic distribution of calcium-mediated electrogenesis in purkinje cells from rat cerebellar slice cultures
Poulas_2000_Clin.Exp.Immunol_120_363Treatment of passively transferred experimental autoimmune myasthenia gravis using papain
Powell_2000_Anesth.Analg_90_1423Ondansetron given before induction of anesthesia reduces shivering after general anesthesia
Prall_2000_Life.Sci_66_835Acetylcholinesterase activity in chronic renal failure
Prasad_2000_Neurochem.Res_25_19Interactions of bovine brain tubulin with pyridostigmine bromide and N,N'-diethyl-m-toluamide
Pratt_2000_J.Biol.Chem_275_29441Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic
Pregelj_2000_Pflugers.Arch_440_R112Effect of mechanical load on acetylcholinesterase mRNA levels in the slow soleus muscle of the rat
Preston_2000_Br.J.Pharmacol_130_886Adenosine receptor expression and function in rat striatal cholinergic interneurons
Preston_2000_Neurosci_95_367Tachykinins increase [3H]acetylcholine release in mouse striatum through multiple receptor subtypes
Prim_2000_Res.Microbiol_151_303estA, a gene coding for a cell-bound esterase from Paenibacillus sp. BP-23, is a new member of the bacterial subclass of type B carboxylesterases
Prins_2000_Br.J.Pharmacol_129_1601An improved in vitro bioassay for the study of 5-HT(4) receptors in the human isolated large intestinal circular muscle
Prior_2000_Br.J.Pharmacol_129_1067Factors influencing the low-frequency associated nicotinic ACh autoreceptor-mediated depression of ACh release from rat motor nerve terminals
Proctor_2000_Curr.Med.Chem_7_295Synthesis of tacrine analogues and their structure-activity relationships
Proenza_2000_Int.J.Obes.Relat.Metab.Disord_24_93Association of sets of alleles of genes encoding beta3-adrenoreceptor, uncoupling protein 1 and lipoprotein lipase with increased risk of metabolic complications in obesity
Pruett_2000_J.Econ.Entomol_93_920Evaluation of horn flies (Diptera: Muscidae) from a pyrethroid susceptible colony for general and permethrin esterase activities
Pruvost_2000_J.Mass.Spectrom_35_625Fully automated determination of eserine N-oxide in human plasma using on-line solid-phase extraction with liquid chromatography coupled with electrospray ionization tandem mass spectrometry
Pudota_2000_Proc.Natl.Acad.Sci.U.S.A_97_13033Identification of the vitamin K-dependent carboxylase active site: Cys-99 and Cys-450 are required for both epoxidation and carboxylation
Puech_2000_Mol.Microbiol_35_1026Characterization of the in vivo acceptors of the mycoloyl residues transferred by the corynebacterial PS1 and the related mycobacterial antigens 85
Qualmann_2000_J.Cell.Biol_148_1047Syndapin isoforms participate in receptor-mediated endocytosis and actin organization
Querfurth_2000_Dement.Geriatr.Cogn.Disord_11_314Acetylcholinesterase inhibition in dementia with Lewy bodies: results of a prospective pilot trial
Quik_2000_Eur.J.Pharmacol_393_223Nicotinic receptors and Parkinson's disease
Quik_2000_Neurosci_100_63Differential alterations in nicotinic receptor alpha6 and beta3 subunit messenger RNAs in monkey substantia nigra after nigrostriatal degeneration
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Reetz_2000_Chemistry_6_407Enantioselective enzymes for organic synthesis created by directed evolution
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Riley_2000_J.Immunol_165_4870Graded deletion and virus-induced activation of autoreactive CD4+ T cells
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Robin_2000_Mol.Biol.Evol_17_563The Evolution of an alpha-Esterase Pseudogene Inactivated in the Drosophila melanogaster Lineage
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Robitzki_2000_Glia_31_195Regulation of the rat oligodendroglia cell line OLN-93 by antisense transfection of butyrylcholinesterase
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Shanmugavelu_2000_J.Biol.Chem_275_1802A novel protein that binds juvenile hormone esterase in fat body tissue and pericardial cells of the tobacco hornworm Manduca sexta L
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Sharples_2000_J.Neurosci_20_2783UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes
Sheets_2000_Neurotoxicol_21_57A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides
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Shibahara_2000_Cytotech_33_247Mannosylerythritol lipid increases levels of galactoceramide in and neurite outgrowth from PC12 pheochromocytoma cells
Shibata_2000_Genome.Res_10_1757RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer
Shigenobu_2000_Nature_407_81Genome sequence of the endocellular bacterial symbiont of aphids Buchnera sp. APS
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Shiotsuki_2000_Biosci.Biotechnol.Biochem_64_1681Characterization and affinity purification of juvenile hormone esterase from Bombyx mori
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Sieber_2000_Plant.Cell_12_721Transgenic Arabidopsis plants expressing a fungal cutinase show alterations in the structure and properties of the cuticle and postgenital organ fusions
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Sihver_2000_Behav.Brain.Res_113_143Development of ligands for in vivo imaging of cerebral nicotinic receptors
Silveira_2000_Brain.Res_878_223Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats
Simpson_2000_Nature_406_151The genome sequence of the plant pathogen Xylella fastidiosa. The Xylella fastidiosa Consortium of the Organization for Nucleotide Sequencing and Analysis
Sinal_2000_J.Biol.Chem_275_40504Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation
Singh_2000_Int.J.Clin.Pharmacol.Ther_38_315Aspirin esterases in North-West Indians: the influence of age and nutrition
Singh_2000_Pest.Manag.Sci_56_889Toxicity to the snail Limnaea acuminata of plant-derived molluscicides in combination with synergists
Sinton_2000_Toxicol.Appl.Pharmacol_165_99Stressful manipulations that elevate corticosterone reduce blood-brain barrier permeability to pyridostigmine in the Rat
Sivilotti_2000_Handb.Exp.Pharmacol_144_379Comparison of Native and Recombinant Neuronal Nicotinic Receptors: Problems of Measurement and Expression
Skehel_2000_Proc.Natl.Acad.Sci.U.S.A_97_1101Mouse VAP33 is associated with the endoplasmic reticulum and microtubules
Skjerve_2000_Int.J.Geriatr.Psychiatry_15_1147Improvement in sundowning in dementia with Lewy bodies after treatment with donepezil
Slack_2000_Biochem.J_348 Pt 2_381The m3 muscarinic acetylcholine receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase
Slemmer_2000_J.Pharmacol.Exp.Ther_295_321Bupropion is a nicotinic antagonist
Small_2000_Insect.Mol.Biol_9_647Molecular characterization of the amplified carboxylesterase gene associated with organophosphorus insecticide resistance in the brown planthopper, Nilaparvata lugens
Smialowski-Fleter_2000_Eur.J.Biochem_267_2227Structure-function relationships in the carboxylic-ester-hydrolase superfamily. Disulfide bridge arrangement in porcine intestinal glycerol-ester hydrolase
Smith_2000_Biochem.Educ_28_76How do proteins fold?
Smith_2000_Gene_247_119Identification and analysis of two snail genes in the pufferfish (Fugu rubripes) and mapping of human SNA to 20q
Smyth_2000_Heredity.(Edinb)_84 ( Pt 1)_63MCE activities and malathion resistances in field populations of the australian sheep blowfly (Lucilia cuprina)
Sohaskey_2000_J.Bacteriol_182_1930Spirochaeta aurantia has diacetyl chloramphenicol esterase activity
Solaiman_2000_Appl.Microbiol.Biotechnol_53_690Rapid and specific identification of medium-chain-length polyhydroxyalkanoate synthase gene by polymerase chain reaction
Solaiman_2000_Biotechnol.Lett_22_789Synthesis of poly(hydroxyalkanoates) by Escherichia coli expressing mutated and chimeric PHA synthase genes
Solomon_2000_Drugs.Today.(Barc)_36_655Vaccination for the prevention and treatment of Alzheimer's disease
Soloviev_2000_Eur.J.Biochem_267_634Mouse brain and muscle tissues constitutively express high levels of Homer proteins
Soloviev_2000_J.Mol.Biol_295_1185Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing
Somani_2000_J.Appl.Toxicol_20_327Interactive and delayed effects of pyridostigmine and physical stress on biochemical and histological changes in peripheral tissues of mice
Song_2000_Biomacromolecules_1_433In vitro polymerization and copolymerization of 3-hydroxypropionyl-CoA with the PHB synthase from Ralstonia eutropha
Song_2000_J.Neurophysiol_83_322Adenosine receptor expression and modulation of Ca(2+) channels in rat striatal cholinergic interneurons
Sorbi_2000_Clin.Neuropharmacol_23_114Double-blind, crossover, placebo-controlled clinical trial with L-acetylcarnitine in patients with degenerative cerebellar ataxia
Soreq_2000_Isr.Med.Assoc.J_2_81Anti-sense approach to anticholinesterase therapeutics
Sorger_2000_Nucl.Med.Biol_27_23In vivo [125I]-iodobenzovesamicol binding reflects cortical cholinergic deficiency induced by specific immunolesion of rat basal forebrain cholinergic system
Southgate_2000_J.R.Soc.Promot.Health_120_127Lessons to be learned: a case study approach. Unseasonal severe poisoning of two adults by deadly nightside (Atropa belladonna)
Spassova_2000_Comp.Biochem.Physiol.C.Toxicol.Pharmacol_126_79Acute effects of acephate and methamidophos on acetylcholinesterase activity, endocrine system and amino acid concentrations in rats
Spicuzza_2000_Br.J.Pharmacol_130_1720Characterization of the effects of cannabinoids on guinea-pig tracheal smooth muscle tone: role in the modulation of acetylcholine release from parasympathetic nerves
Spiegelstein_2000_Pharm.Res_17_216Structure activity relationship of human microsomal epoxide hydrolase inhibition by amide and acid analogues of valproic acid
Sramek_2000_Alzheimer.Dis.Assoc.Disord_14_216RBC cholinesterase inhibition: a useful surrogate marker for cholinesterase inhibitor activity in Alzheimer disease therapy?
Sramek_2000_Expert.Opin.Investig.Drugs_9_2393Review of the acetylcholinesterase inhibitor galanthamine
Srivastava_2000_Food.Chem.Toxicol_38_65Clinical, biochemical and neurobehavioural studies of workers engaged in the manufacture of quinalphos
Srivastava_2000_Vet.Hum.Toxicol_42_212Effect of diacetylmonoxime on blood enzymes in fenitrothion-dosed buffalo calves
Stahl_2000_J.Clin.Psychiatry_61_710The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different
Stahl_2000_J.Clin.Psychiatry_61_813The new cholinesterase inhibitors for Alzheimer's disease, Part 2: illustrating their mechanisms of action
Stander_2000_J.Agric.Food.Chem_48_5736Screening of commercial hydrolases for the degradation of ochratoxin A
Steevens_2000_Mar.Environ.Res_50_113Interactions of chlorpyrifos and methyl mercury: a mechanistic approach to assess chemical mixtures
Steinlein_2000_Eur.J.Pharmacol_393_243Neuronal nicotinic receptors in human epilepsy
Stern_2000_FEMS.Microbiol.Lett_185_163The polyester polyurethanase gene (pueA) from Pseudomonas chlororaphis encodes a lipase
Sternfeld_2000_Proc.Natl.Acad.Sci.U.S.A_97_8647Excess read-through acetylcholinesterase attenuates but the synaptic variant intensifies neurodeterioration correlates
Sternini_2000_Neurosci_98_233Role of agonist-dependent receptor internalization in the regulation of mu opioid receptors
Stinear_2000_J.Bacteriol_182_6322Comparative genetic analysis of Mycobacterium ulcerans and Mycobacterium marinum reveals evidence of recent divergence
Stitzel_2000_Handb.Exp.Pharmacol_144_563Genetic Regulation of Nicotine-Related Behaviors and Brain Nicotinic Receptors
Stockel-Maschek_2000_Adv.Exp.Med.Biol_477_117Potent inhibitors of dipeptidyl peptidase IV and their mechanisms of inhibition
Stocks_2000_Atherosclerosis_149_219A common lecithin: cholesterol acyltransferase gene variant (Ser208-->Thr)
Stolerman_2000_Eur.J.Pharmacol_393_147Nicotine in an animal model of attention
Stoltzman_2000_J.Insect.Physiol_46_771Stage-specific production and release of juvenile hormone esterase from the ovary of Diploptera punctata
Stone_2000_Brain.Res_882_9Protractive effects of chronic treatment with an acutely sub-toxic regimen of diisopropylflurophosphate on the expression of cholinergic receptor densities in rats
Stoppe_2000_Internist.(Berl)_41_538[Chief psychiatric problems in old age]
Storm_2000_Toxicology_150_1Occupational exposure limits for 30 organophosphate pesticides based on inhibition of red blood cell acetylcholinesterase
Stover_2000_Nature_406_959Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
Strnad_2000_Dtsch.Med.Wochenschr_125_835[The pharmacotherapy of the cognitive disorders in Alzheimer's disease. Guidelines for rational drug use--a review]
Stromgaard_2000_J.Med.Chem_43_4526Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues
Sucgang_2000_J.Eukaryot.Microbiol_47_334Toward the functional analysis of the Dictyostelium discoideum genome
Sudakin_2000_J.Toxicol.Clin.Toxicol_38_47Intermediate syndrome after malathion ingestion despite continuous infusion of pralidoxime
Sudweeks_2000_J.Physiol_527 Pt 3_515Functional and molecular characterization of neuronal nicotinic ACh receptors in rat CA1 hippocampal neurons
Sugimoto_2000_Curr.Med.Chem_7_303Donepezil Hydrochloride (E2020) and Other Acetylcholinesterase Inhibitors
Sulaiman_2000_J.Pathol_192_396Growth of nerve fibres into murine peritoneal adhesions
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Sun_2000_Arch.Oral.Biol_45_621Effects of low concentrations of paraoxon on Ca(2+) mobilization in a human parotid salivary cell-line HSY
Sun_2000_Virology_276_27Characterization of a beta-1,3-glucanase encoded by chlorella virus PBCV-1
Sunami_2000_J.Toxicol.Sci_25_403Evaluation of a 5-day Hershberger assay using young mature male rats: methyltestosterone and p,p'-DDE, but not fenitrothion, exhibited androgenic or antiandrogenic activity in vivo
Sunanda_2000_Neurochem.Res_25_1547Restraint stress-induced alterations in the levels of biogenic amines, amino acids, and AChE activity in the hippocampus
Sundquist_2000_Pharmacol.Toxicol_86_44Pharmacological characterisation of the enantiomers of BM-5, a muscarinic partial agonist with opposed enantioselectivity between affinity and efficacy
Suwa_2000_Gene_246_123Identification of two polyketide synthase gene clusters on the linear plasmid pSLA2-L in Streptomyces rochei
Suyatna_2000_Int.J.Clin.Pharmacol.Ther_38_339Butyrylcholinesterase and C5+ variant in a Javanese ethnic group in Indonesia
Suzuki_2000_Arch.Biochem.Biophys_379_344Mechanism of selective release of membrane proteins from human erythrocytes in the presence of liposomes
Suzuki_2000_Biochemistry_39_9477GPI-Linked proteins Do not transfer spontaneously from erythrocytes to liposomes. New aspects of reorganization of the cell membrane
Suzuki_2000_Gene_242_331Complete nucleotide sequence of a plant tumor-inducing Ti plasmid.
Svendsen_2000_Biochim.Biophys.Acta_1543_223Lipase protein engineering
Svensson_2000_Behav.Brain.Res_113_193Tacrine interacts with different sites on nicotinic receptor subtypes in SH-SY5Y neuroblastoma and M10 cells
Sweet_2000_J.Clin.Psychopharmacol_20_181Pharmacologic profile of perphenazine's metabolites
Sweileh_2000_Brain.Res.Mol.Brain.Res_75_293Multistep expression and assembly of neuronal nicotinic receptors is both host-cell- and receptor-subtype-dependent
Swiatkiewicz_2000_Folia.Biol.(Krakow)_48_97The presence of acetylcholinesterase-positive nerve fibres in the deep pineal gland and the pineal stalk but not in the superficial part of adult albino rats
Szeltner_2000_J.Biol.Chem_275_15000The noncatalytic beta-propeller domain of prolyl oligopeptidase enhances the catalytic capability of the peptidase domain
Szenohradszky_2000_Anesthesiology_92_708Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium
Szewczyk_2000_J.Cell.Sci_113_2003Genetic defects in acetylcholine signalling promote protein degradation in muscle cells of Caenorhabditis elegans
Szlendak_2000_Exp.Appl.Acarol_24_45Pirimiphos-methyl resistance in two stored product mites, Acarus siro and Acarus farris, as detected by impregnated paper bioassay and esterase activity assays
Tabata_2000_Nature_408_823Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana
Taghvaei_2000_J.Biotechnol_81_107Adsorptive immobilization of erythrocyte membrane
Takagi_2000_Biochim.Biophys.Acta_1502_433A newly identified lipoprotein lipase (LPL) gene mutation (F270L) in a Japanese patient with familial LPL deficiency
Takahashi_2000_Prostate_44_328Low-dose staurosporine suppresses proliferation and induces neurites in human prostatic cancer TSU-Pr1 cells
Takai_2000_Infect.Immun_68_6840DNA sequence and comparison of virulence plasmids from Rhodococcus equi ATCC 33701 and 103
Takami_2000_Nucleic.Acids.Res_28_4317Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans and genomic sequence comparison with Bacillus subtilis
Takamiya_2000_Trends.Plant.Sci_5_426Degradation pathway(s) of chlorophyll: what has gene cloning revealed?
Takeda_2000_J.Biosci.Bioeng_90_416Cloning and expression of the gene encoding thermostable poly(3-hydroxybutyrate) depolymerase.
Takeda_2000_Nippon.Ronen.Igakkai.Zasshi_37_879[Treatment of the elderly dementia patients]
Takeuchi_2000_World.J.Gastroenterol_6_651Stimulation by nizatidine, a histamine H(2)-receptor antagonist, of duodenal HCO(3)(-)secretion in rats:relation to anti-cholinesterase activity
Takeyabu_2000_Eur.Respir.J_15_891Gene polymorphism for microsomal epoxide hydrolase and susceptibility to emphysema in a Japanese population
Takiguchi_2000_J.Hum.Genet_45_200Structural and functional study of K453E mutant protective protein/cathepsin A causing the late infantile form of galactosialidosis
Talalay_2000_Biofactors_12_5Chemoprotection against cancer by induction of phase 2 enzymes
Talbot_2000_Genes.Dev_14_755Zebrafish mutations and functional analysis of the vertebrate genome
Tanaka_2000_J.Biochem_127_597Glutathione as an essential factor for chaperon-mediated activation of lactonizing lipase (LipL) from Pseudomonas sp. 109
Tanaka_2000_Pharmacol.Biochem.Behav_66_827Recovery of diminished mealtime-associated anticipatory behavior by aniracetam in aged rats
Tang_2000_Biophys.J_78_2735Effects of mobile buffers on facilitation: experimental and computational studies
Tang_2000_Science_287_640Cloning and heterologous expression of the epothilone gene cluster
Tariot_2000_Neurology_54_2269A 5-month, randomized, placebo-controlled trial of galantamine in AD. The Galantamine USA-10 Study Group
Tata_2000_Brain.Res_866_65Muscarinic receptors modulate intracellular calcium level in chick sensory neurons
Taten_2000_Proc.(Bayl.Univ.Med.Cent)_13_419Epigastric pain with elevated serum calcium, lipase, and amylase
Taura_2000_Biochem.Biophys.Res.Commun_273_1048Interaction between cytochrome P450 and other drug-metabolizing enzymes: evidence for an association of CYP1A1 with microsomal epoxide hydrolase and UDP-glucuronosyltransferase
Taylor_2000_Handb.Exp.Pharmacol_144_79Contributions of Studies of the Nicotinic Receptor from Muscle to Defining Structural and Functional Properties of Ligand-Gated Ion Channels
Taylor_2000_Pflugers.Arch_440_R115Subunit interface selective toxins as probes of nicotinic acetylcholine receptor structure
Tecle_2000_Pharm.Acta.Helv_74_141CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology
Tecles_2000_Vet.J_160_242Use of whole blood for spectrophotometric determination of cholinesterase activity in dogs
Teiber_2000_Carcinogenesis_21_1559Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine
Terao_2000_Lancet_355_2168Charles Bonnet syndrome and dementia
Terzyan_2000_Protein.Sci_9_1783Crystal structure of the catalytic domain of human bile salt activated lipase
Tessier_2000_Aquat.Toxicol_50_125Anomalies on capture nets of Hydropsyche slossonae larvae (Trichoptera; Hydropsychidae), a potential indicator of chronic toxicity of malathion (organophosphate insecticide)
Testai_2000_Neurochem.Int_36_27Histidine 186 of the nicotinic acetylcholine receptor alpha subunit requires the presence of the 192-193 disulfide bridge to interact with alpha-bungarotoxin
Tettelin_2000_Science_287_1809Complete genome sequence of Neisseria meningitidis serogroup B strain MC58
Thal_2000_Neurology_55_805A 1-year controlled trial of acetyl-l-carnitine in early-onset AD
Thatte_2000_IDrugs_3_1222Phenserine (Axonyx/NIH)
Theologis_2000_Nature_408_816Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana
Thomas_2000_Curr.Biol_10_1108Synaptic targeting and localization of discs-large is a stepwise process controlled by different domains of the protein
Thomas_2000_Insect.Biochem.Mol.Biol_30_529Isolation of juvenile hormone esterase and its partial cDNA clone from the beetle, Tenebrio molitor
Thomas_2000_Int.J.Biol.Macromol_27_145Endo-1,3;1,4-beta-glucanase from coleoptiles of rice and maize: role in the regulation of plant growth
Thor_2000_Brain.Res_870_126Central muscarinic inhibition of lower urinary tract nociception
Thornton_2000_Nat.Struct.Biol_7 Suppl_991From structure to function: approaches and limitations
Thum_2000_Lancet_355_979Gene expression in distinct regions of the heart
Tian_2000_Toxicol.Appl.Pharmacol_167_246Upregulation of tyrosine hydroxylase and downregulation of choline acetyltransferase in lead-exposed PC12 cells: the role of PKC activation
Tierney_2000_J.Mol.Biol_303_185Electron microscopic evidence for the assembly of soluble pentameric extracellular domains of the nicotinic acetylcholine receptor
Tillett_2000_Chem.Biol_7_753Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide-polyketide synthetase system
Toida_2000_FEMS.Microbiol.Lett_189_159Cloning and sequencing of the triacylglycerol lipase gene of Aspergillus oryzae and its expression in Escherichia coli
Tojima_2000_Neurosci.Res_37_153Acquisition of neuronal proteins during differentiation of NG108-15 cells
Tolstykh_2000_Embo.J_19_5682Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits
Tomita_2000_Insect.Biochem.Mol.Biol_30_325Absence of protein polymorphism attributable to insecticide-insensitivity of acetylcholinesterase in the green rice leafhopper, Nephotettix cincticeps
Tomita_2000_Keio.J.Med_49_26Regulation of cerebral microcirculation--update
Tomizawa_2000_J.Agric.Food.Chem_48_6016Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors
Tomizawa_2000_Toxicol.Appl.Pharmacol_169_114Imidacloprid, thiacloprid, and their imine derivatives up-regulate the alpha 4 beta 2 nicotinic acetylcholine receptor in M10 cells
Tong_2000_Eur.J.Neurosci_12_2769Basal forebrain nitric oxide synthase (NOS)-containing neurons project to microvessels and NOS neurons in the rat neocortex: cellular basis for cortical blood flow regulation
Torrao_2000_Brain.Res.Dev.Brain.Res_124_81Expression of cholinergic system molecules during development of the chick nervous system
Torrao_2000_Brain.Res_863_249Effects of cholinergic deafferentation upon the expression of the alpha2 subunit of the nicotinic acetylcholine receptors in the chick lateral spiriform nucleus
Toth_2000_Electromyogr.Clin.Neurophysiol_40_17The diagnostic value of stapedius reflex and stapedius reflex exhaustion in myasthenia gravis
Trabace_2000_Brain.Res_865_268In vivo neurochemical effects of the acetylcholinesterase inhibitor ENA713 in rat hippocampus
Trabace_2000_J.Pharmacol.Exp.Ther_294_187Biochemical and neurobehavioral profile of CHF2819, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease
Tramontano_2000_Appl.Biochem.Biotechnol_83_233Inhibition and labeling of enzymes and abzymes by phosphonate diesters
Tremere_2000_Neuroreport_11_2177Antibody for human p75 LNTR identifies cholinergic basal forebrain of non-primate species
Trevisani_2000_Dis.Colon.Rectum_43_599Neostigmine: safe and effective treatment for acute colonic pseudo-obstruction
Trinidad_2000_J.Neurosci_20_8762The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction
Troy_2000_J.Clin.Psychopharmacol_20_328Comparison of the effects of zaleplon, zolpidem, and triazolam on memory, learning, and psychomotor performance
Tsakiris_2000_Clin.Biochem_33_103Protective effect of L-phenylalanine on rat brain acetylcholinesterase inhibition induced by free radicals
Tsakiris_2000_Z.Naturforsch.C_55_852The effect of galactose metabolic disorders on rat brain acetylcholinesterase activity
Tsang_2000_Brain.Res_861_45Motor neurons are rich in non-phosphorylated neurofilaments: cross-species comparison and alterations in ALS
Tsigelny_2000_Protein.Sci_9_180Common EF-hand motifs in cholinesterases and neuroligins suggest a role for Ca2+ binding in cell surface associations
Tsouloufis_2000_Int.Immunol_12_1255Reconstitution of conformationally dependent epitopes on the N-terminal extracellular domain of the human muscle acetylcholine receptor alpha subunit expressed in Escherichia coli: implications for myasthenia gravis therapeutic approaches
Tsuga_2000_Neurotoxicol.Teratol_22_603Effects of short-term toluene exposure on ligand binding to muscarinic acetylcholine receptors in the rat frontal cortex and hippocampus
Tsugawa_2000_Appl.Biochem.Biotechnol_84-86_311Improvement of enantioselectivity of chiral organophosphate insecticide hydrolysis by bacterial phosphotriesterase
Tsukada_2000_Brain.Res_857_158Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain
Tullu_2000_Indian.Pediatr_37_88Dorfman-Chanarin syndrome: a rare neutral lipid storage disease
Tulman_2000_J.Virol_74_7980The genome of a very virulent Marek's disease virus
Tumiatti_2000_Arzneimittelforschung_50_11Muscarinic properties of compounds related to arecaidine propargyl ester
Tumiatti_2000_Bioorg.Med.Chem_8_681[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors
Turchi_2000_Eur.J.Neurosci_12_4505Cortical cholinergic inputs mediate processing capacity: effects of 192 IgG-saporin-induced lesions on olfactory span performance
Turi_2000_Acta.Vet.Hung_48_139Determination of residues of pyrethroid and organophosphorous ectoparasiticides in foods of animal origin
Turski_2000_Pol.J.Pharmacol_52_63Pilocarpine-induced seizures in rodents--17 years on
Ueda_2000_J.Biosci.Bioeng_90_125Cell surface engineering of yeast: construction of arming yeast with biocatalyst
Ueno_2000_Genes.Cells_5_859Involvement of fatty acid synthase in axonal development in mouse embryos
Unni_2000_Methods.Find.Exp.Clin.Pharmacol_22_57The recovery of cerebrospinal fluid acetylcholinesterase activity in Alzheimer's disease patients after treatment with metrifonate
Uphoff_2000_Leuk.Lymphoma_39_257Biology of monocyte-specific esterase
Uyeda_2000_Biochem.Biophys.Res.Commun_269_564MDP77: A novel neurite-outgrowth-promoting protein predominantly expressed in chick muscles
Uyeda_2000_Neurosci.Lett_284_61Chick muscle-derived protein 62: a novel neurite outgrowth promoting protein
Vailati_2000_Eur.J.Pharmacol_393_23beta3 subunit is present in different nicotinic receptor subtypes in chick retina
Vais_2000_FEBS.Lett_470_135A single amino acid change makes a rat neuronal sodium channel highly sensitive to pyrethroid insecticides
Vais_2000_J.Gen.Physiol_115_305Activation of Drosophila sodium channels promotes modification by deltamethrin. Reductions in affinity caused by knock-down resistance mutations
Van Belle_2000_J.Mol.Biol_298_705Pathways of ligand clearance in acetylcholinesterase by multiple copy sampling
Van Dyke_2000_Ann.Pharmacother_34_639Pharmacogenetic screening for susceptibility to fetal malformations in women
Van Renterghe_2000_Eur.J.Neurosci_12_3953alpha-latrotoxin forms calcium-permeable membrane pores via interactions with latrophilin or neurexin
VanDenBerg_2000_Drugs.Aging_16_123Cholinesterase inhibitors for the treatment of Alzheimer's disease in the elderly
Varmanen_2000_J.Bacteriol_182_146X-prolyl dipeptidyl aminopeptidase gene (pepX) is part of the glnRA operon in Lactobacillus rhamnosus
Varnagy_2000_Acta.Vet.Hung_48_113Interaction of Dithane M-45 (mancozeb) and lead acetate during a teratogenicity test in rats
Vayron_2000_Proc.Natl.Acad.Sci.U.S.A_97_7058Toward antibody-catalyzed hydrolysis of organophosphorus poisons
Vedler_2000_Gene_245_161TfdR, the LysR-type transcriptional activator, is responsible for the activation of the tfdCB operon of Pseudomonas putida 2, 4-dichlorophenoxyacetic acid degradative plasmid pEST4011
Vedler_2000_Gene_255_281Analysis of the 2,4-dichlorophenoxyacetic acid-degradative plasmid pEST4011 of Achromobacter xylosoxidans subsp. denitrificans strain EST4002
Verbitsky_2000_Neuropharmacol_39_2515Mixed nicotinic-muscarinic properties of the alpha9 nicotinic cholinergic receptor
Verhage_2000_Science_287_864Synaptic assembly of the brain in the absence of neurotransmitter secretion
Verma-Ahuja_2000_Arch.Toxicol_74_539Delayed effects of pyridostigmine and exercise training on acetylcholinesterase and muscle tension in mouse lower extremity
Vernino_2000_N.Engl.J.Med_343_847Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies
Verrico_2000_J.Am.Geriatr.Soc_48_1659Fulminant chemical hepatitis possibly associated with donepezil and sertraline therapy
Verripsab_2000_Enzyme.Microb.Technol_26_812From gene to product in yeast: production of fungal cutinase
Vijay_2000_Mol.Microbiol_35_180A PP2C phosphatase containing a PAS domain is required to convey signals of energy stress to the sigmaB transcription factor of Bacillus subtilis
Villalobos_2000_Aquat.Toxicol_48_309Thiobencarb-induced embryotoxicity in medaka (Oryzias latipes): stage-specific toxicity and the protective role of chorion
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Villatte_2000_Pestic.Biochem.Physiol_67_95A High Number of Mutations in Insect Acetylcholinesterase May Provide Insecticide Resistance
Viragh_2000_Biochemistry_39_16200NMR evidence for a short, strong hydrogen bond at the active site of a cholinesterase
Visser_2000_Appl.Microbiol.Biotechnol_53_415Cloning and characterization of an epoxide hydrolase-encoding gene from Rhodotorula glutinis
Vizi_2000_Pharmacol.Rev_52_63Role of high-affinity receptors and membrane transporters in nonsynaptic communication and drug action in the central nervous system
Vlahos_2000_J.Auton.Pharmacol_20_237Influence of the epithelium on acetylcholine release from parasympathetic nerves of the rat trachea
Volchegursky_2000_Mol.Microbiol_37_752Biosynthesis of the anti-parasitic agent megalomicin: transformation of erythromycin to megalomicin in Saccharopolyspora erythraea
Volsen_2000_Methods.Enzymol_314_290Application of antisense techniques to characterize neuronal ion channels in vitro
Waggoner_2000_J.Neurosci_20_8802Long-term nicotine adaptation in Caenorhabditis elegans involves PKC-dependent changes in nicotinic receptor abundance
Wajima_2000_Anaesth.Intensive.Care_28_46The effect of previous administration of nizatidine on the neuromuscular effects of vecuronium and the effect of nizatidine on gastric secretion
Walczak_2000_FEMS.Microbiol.Lett_183_171Nonactin biosynthesis: the potential nonactin biosynthesis gene cluster contains type II polyketide synthase-like genes.
Waldo_2000_Biol.Psychiatry_47_231Familial transmission of risk factors in the first-degree relatives of schizophrenic people
Waldstein_2000_J.Econ.Entomol_93_1768Synergism of tebufenozide in resistant and susceptible strains of obliquebanded leafroller (Lepidoptera: Tortricidae) and resistance to new insecticides
Waliany_2000_Hum.Mutat_15_206Identification of three novel mutations of the palmitoyl-protein thioesterase-1 (PPT1) gene in children with neuronal ceroid-lipofuscinosis
Walsh_2000_Mol.Cell.Neurosci_15_244Ectopic expression of NCAM in skeletal muscle of transgenic mice results in terminal sprouting at the neuromuscular junction and altered structure but not function
Wan_2000_Neurosci.Lett_288_81The promoter of human acetylcholinesterase is activated by a cyclic adenosine 3',5'-monophosphate-dependent pathway in cultured NG108-15 neuroblastoma cells
Wan_2000_Talanta_52_663Enzyme-octadecylamine Langmuir-Blodgett membranes for ENFET biosensors
Wang_2000_Am.J.Physiol.Gastrointest.Liver.Physiol_279_G1059Human esophageal smooth muscle cells express muscarinic receptor subtypes M(1) through M(5)
Wang_2000_Antimicrob.Agents.Chemother_44_3040Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489
Wang_2000_Arch.Biochem.Biophys_382_31Affinity purification and characterization of a cutinase from the fungal plant pathogen Monilinia fructicola (Wint.) honey
Wang_2000_Biochim.Biophys.Acta_1480_191Modifications of aclacinomycin T by aclacinomycin methyl esterase (RdmC) and aclacinomycin-10-hydroxylase (RdmB) from Streptomyces purpurascens
Wang_2000_Bioorg.Med.Chem.Lett_10_2247Design and synthesis of piperidinyl piperidine analogues as potent and selective M2 muscarinic receptor antagonists
Wang_2000_Environ.Health.Perspect_108_1103An unusual case of organophosphate intoxication of a worker in a plastic bottle recycling plant: an important reminder
Wang_2000_Eur.J.Pharmacol_398_65Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats
Wang_2000_J.Gen.Physiol_116_449Fundamental gating mechanism of nicotinic receptor channel revealed by mutation causing a congenital myasthenic syndrome
Wang_2000_Neuropharmacol_39_497Gender differences in the effect of rivastigmine on brain cholinesterase activity and cognitive function in rats
Ward_2000_Exp.Neurol_162_297BDNF is needed for postnatal maturation of basal forebrain and neostriatum cholinergic neurons in vivo
Ward_2000_Neurobiol.Aging_21_125Cholinergic medial septum neurons do not degenerate in aged 129/Sv control or p75(NGFR)-/-mice
Watanabe_2000_J.Biol.Chem_275_31016Versatile transcription of biphenyl catabolic bph operon in Pseudomonas pseudoalcaligenes KF707
Waterman_2000_Arthritis.Rheum_43_1647Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjogren's syndrome
Watkins_2000_J.Pharmacol.Exp.Ther_292_1053Reward and somatic changes during precipitated nicotine withdrawal in rats: centrally and peripherally mediated effects
Weber_2000_Chem.Phys.Lipids_105_215Antioxidants eliminate stereomutation and thioether formation during lipase-catalyzed thioesterification and transthioesterification for the preparation of uniform cis- and trans-unsaturated thioesters
Weber_2000_Structure_8_407Solution structure of PCP, a prototype for the peptidyl carrier domains of modular peptide synthetases
Wei_2000_Biochem.Pharmacol_60_121High-level expression of human butyrylcholinesterase gene in Bombyx mori and biochemical-pharmacological characteristic study of its product
Weihe_2000_FASEB.J_14_2435Chemical neuroanatomy of the vesicular amine transporters
Weik_2000_Proc.Natl.Acad.Sci.U.S.A_97_623Specific chemical and structural damage to proteins produced by synchrotron radiation
Weiland_2000_Behav.Brain.Res_113_43Neuronal nicotinic acetylcholine receptors: from the gene to the disease
Weill_2000_Anal.Biochem_285_267Quantitative polymerase chain reaction to estimate the number of amplified esterase genes in insecticide-resistant mosquitoes
Weill_2000_Insect.Mol.Biol_9_451The kdr mutation occurs in the Mopti form of Anopheles gambiae s.s. through introgression
Weinbroum_2000_Resuscitation_47_113Anaesthesia and critical care considerations in nerve agent warfare trauma casualties
Weiner_2000_J.Clin.Psychiatry_61_487Effects of donepezil on emotional/behavioral symptoms in Alzheimer's disease patients
Weinstock_2000_J.Neural.Transm.Suppl__157TV3326, a novel neuroprotective drug with cholinesterase and monoamine oxidase inhibitory activities for the treatment of Alzheimer's disease
Wenk_2000_Life.Sci_66_1079No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use
Wenker_2000_Toxicol.Appl.Pharmacol_169_52Metabolism of styrene-7,8-oxide in human liver in vitro: interindividual variation and stereochemistry
Werbonat_2000_J.Biol.Chem_275_21969Essential role of dynamin in internalization of M2 muscarinic acetylcholine and angiotensin AT1A receptors
Wester_2000_Toxicol.Appl.Pharmacol_168_149Predicted chemical warfare agent VX toxicity to uniformed soldier using parathion in vitro human skin exposure and absorption
Weston_2000_Exp.Cell.Res_260_374Laminin-1 activates Cdc42 in the mechanism of laminin-1-mediated neurite outgrowth
Weston_2000_J.Cell.Biol_150_205Agrin-induced acetylcholine receptor clustering is mediated by the small guanosine triphosphatases Rac and Cdc42
Wettstein_2000_Phytomedicine_6_393Cholinesterase inhibitors and Gingko extracts--are they comparable in the treatment of dementia? Comparison of published placebo-controlled efficacy studies of at least six months' duration
Whelan_2000_Ann.Clin.Psychiatry_12_131Donepezil in the treatment of cognitive dysfunction associated with traumatic brain injury
White_2000_Mol.Microbiol_36_662AglU, a protein required for gliding motility and spore maturation of Myxococcus xanthus, is related to WD-repeat proteins
Whiteaker_2000_Eur.J.Pharmacol_393_123Pharmacological and null mutation approaches reveal nicotinic receptor diversity
Wierdl_2000_Biochem.Pharmacol_59_773Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation
Wild_2000_Int.J.Cancer_86_1Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia
Wilens_2000_J.Child.Adolesc.Psychopharmacol_10_217Adjunctive donepezil in attention deficit hyperactivity disorder youth: case series
Willeman_2000_Enzyme.Microb.Technol_27_423Estimation of kinetic parameters by progress curve analysis for the synthesis of (R)-mandelonitrile by Prunus amygdalus hydroxynitrile lyase
Willett_2000_Toxicol.Sci_58_68Comparative metabolism and excretion of benzo(a)pyrene in 2 species of ictalurid catfish
Williams_2000_Cancer.Res_60_4667Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer
Wilson_2000_Faseb.J_14_791Glutathione S-transferase M1 null genotype is associated with a decreased risk of myocardial infarction
Wilson_2000_J.Androl_21_220Dipeptidylpeptidase IV activities are elevated in prostate cancers and adjacent benign hyperplastic glands
Wilson_2000_J.Gen.Physiol_115_93The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel
Windgassen_2000_FEMS.Microbiol.Lett_193_201Rapid gene inactivation in Pseudomonas aeruginosa
Windisch_2000_J.Neural.Transm.Suppl_59_301Approach towards an integrative drug treatment of Alzheimer's disease
Wlodek_2000_Biopolymers_53_265Electrostatic steering of substrate to acetylcholinesterase: analysis of field fluctuations
Wollenberg_2000_Acta.Derm.Venereol_80_39Dorfman-Chanarin syndrome in a Turkish kindred: conductor diagnosis requires analysis of multiple eosinophils
Wolpowitz_2000_Neuron_25_79Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses
Womer_2000_Neuropharmacol_39_2499Reversal of pertussis toxin-induced thermal allodynia by muscarinic cholinergic agonists in mice
Wong_2000_Biochemistry_39_5750Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis
Wong_2000_Biol.Psychiatry_47_818Reboxetine: a pharmacologically potent, selective, and specific norepinephrine reuptake inhibitor
Wong_2000_Toxicol.Lett_115_17Polymorphisms of the gene for microsomal epoxide hydrolase and susceptibility to alcoholic liver disease and hepatocellular carcinoma in a Caucasian population
Wonnacott_2000_Eur.J.Pharmacol_393_51Presynaptic nicotinic receptors modulating dopamine release in the rat striatum
Woodruff-Pak_2000_Behav.Brain.Res_113_11Nicotinic modulation in an animal model of a form of associative learning impaired in Alzheimer's disease
Worek_2000_Arch.Toxicol_74_21Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase
Wright_2000_J.Econ.Entomol_93_7Larval susceptibility of an insecticide-resistant western corn rootworm (Coleoptera: Chrysomelidae) population to soil insecticides: laboratory bioassays, assays of detoxification enzymes, and field performance
Wrobel_2000_Anat.Embryol.(Berl)_202_475Morphogenesis of the bovine rete testis: the intratesticular rete and its connection to the seminiferous tubules
Wrobel_2000_Ann.Anat_182_13On the innervation of the donkey testis
Wu_2000_EMBO.J_19_1963MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type
Wu_2000_EMBO.J_19_5672Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo
Wu_2000_Exp.Neurol_165_306Cyto- and chemoarchitecture of basal forebrain cholinergic neurons in the common marmoset (Callithrix jacchus)
Wu_2000_Gene_251_81The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units
Wu_2000_Hunan.Yi.Ke.Da.Xue.Xue.Bao_25_529[Innervation of medial olivocochlear efferents in the cochlea of gerbils]
Wu_2000_J.Comp.Neurol_423_140Converging evidence from microstimulation, architecture, and connections for multiple motor areas in the frontal and cingulate cortex of prosimian primates
Wu_2000_Neurosci.Lett_288_95Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor [corrected]
Wu_2000_Neurosci.Lett_290_84Corrigendum to 'Protection against ischemic injury in primary cultured mouse astrocytes by bis(7)-tacrine, a novel acetylcholinesterase inhibitor'
Xavier_2000_Biosens.Bioelectron_14_895Fiber optic monitoring of carbamate pesticides using porous glass with covalently bound chlorophenol red
Xiao_2000_J.Neurosci.Res_61_564Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury
Xiao_2000_Neurosci.Lett_286_155Protective effects of huperzine A on beta-amyloid(25-35) induced oxidative injury in rat pheochromocytoma cells
Xiao_2000_Neurosci.Lett_290_197Bis(7)-tacrine, a promising anti-Alzheimer's agent, reduces hydrogen peroxide-induced injury in rat pheochromocytoma cells: comparison with tacrine
Xie_2000_J.Pharmacol.Exp.Ther_293_896Postnatal developmental delay and supersensitivity to organophosphate in gene-targeted mice lacking acetylcholinesterase
Xin_2000_Enzyme.Microb.Technol_26_137Improvement of the enantioselectivity of lipase-catalyzed naproxen ester hydrolysis in organic solvent
Xiong_2000_Science_289_1724Molecular evidence for the early evolution of photosynthesis
Xu_2000_Am.J.Kidney.Dis_36_42Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome
Xue_2000_Gene_245_203Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides
Yada_2000_Zoolog.Sci_17_1123Effects of Desacetyl-alpha-MSH on Lipid Mobilization in the Rainbow Trout, Oncorhynchus mykiss
Yamada_2000_Atherosclerosis_150_209Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population
Yamada_2000_J.Biol.Chem_275_23082Biochemical evidence for the involvement of tyrosine in epoxide activation during the catalytic cycle of epoxide hydrolase
Yang_2000_Exp.Neurol_166_166Open-loop and closed-loop optokinetic nystagmus (OKN) in myasthenia gravis and nonmyasthenic subjects
Yang_2000_Int.J.Biochem.Cell.Biol_32_549Neurotoxin 6-aminonicotinamide affects levels of soluble proteins and enzyme activities in various tissues of golden hamsters
Yang_2000_J.Lipid.Res_41_48The open lid mediates pancreatic lipase function
Yang_2000_J.Toxicol.Clin.Toxicol_38_43Carbofuran-induced delayed neuropathy
Yang_2000_Pediatr.Res_47_184Discoordinate expression of pancreatic lipase and two related proteins in the human fetal pancreas
Yano_2000_Toxicol.Sci_53_135Lack of carcinogenicity of chlorpyrifos insecticide in a high-dose, 2-year dietary toxicity study in Fischer 344 rats
Yao_2000_J.Neurosci_20_2626Spontaneous acetylcholine secretion from developing growth cones of Drosophila central neurons in culture: effects of cAMP-pathway mutations
Yasuda_2000_J.Biosci.Bioeng_90_681Effect of additives on transesterification activity of Rhizopus chinensis lipase
Yates_2000_Mayo.Clin.Proc_75_401Physostigmine in the treatment of gamma-hydroxybutyric acid overdose
Ye_2000_Biochim.Biophys.Acta_1493_373Identification of a novel FAS/ER-alpha fusion transcript expressed in human cancer cells
Yen_2000_Crit.Care.Med_28_2805Spectral analysis of systemic arterial pressure and heart rate signals of patients with acute respiratory failure induced by severe organophosphate poisoning
Yeomans_2000_J.Neurosci_20_8861Brain-stimulation reward thresholds raised by an antisense oligonucleotide for the M5 muscarinic receptor infused near dopamine cells
Yim_2000_Thorax_55_121Genetic susceptibility to chronic obstructive pulmonary disease in Koreans: combined analysis of polymorphic genotypes for microsomal epoxide hydrolase and glutathione S-transferase M1 and T1
Yli-Mattila_2000_Exp.Appl.Acarol_24_863Species and strain identification of the predatory mite Euseius finlandicus by RAPD-PCR and ITS sequences
Yokoo_2000_Brain.Res_873_149Inhibition by neuroprotective drug NS-7 of nicotine-induced 22Na(+) influx, 45Ca(2+) influx and catecholamine secretion in adrenal chromaffin cells
Yokotani_2000_Eur.J.Pharmacol_392_23Histamine H(3) receptor-mediated inhibition of endogenous acetylcholine release from the isolated, vascularly perfused rat stomach
Yorston_2000_J.Psychopharmacol_14_303Hypnopompic hallucinations with donepezil
Yoshida_2000_J.Atheroscler.Thromb_7_45A Japanese patient with lipoprotein lipase deficiency homozygous for the Gly188Glu mutation prevalent worldwide
Yoshikawa_2000_Int.J.Mol.Med_5_49Microsomal epoxide hydrolase genotypes and chronic obstructive pulmonary disease in Japanese
Yoshiyama_2000_Genetica_108_81Survey of mariner-like elements in the housefly, Musca domestica
Young_2000_J.Morphol_245_130Examination of intrafascicular muscle fiber terminations: implications for tension delivery in series-fibered muscles
Yu_2000_Circ.Res_87_992Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids
Yu_2000_Gene_248_157Cloning and characterization of avfA and omtB genes involved in aflatoxin biosynthesis in three Aspergillus species
Zabinski_2000_Toxicol.Ind.Health_16_58The activity of erythrocyte enzymes and basic indices of peripheral blood erythrocytes from workers chronically exposed to mercury vapours
Zaborszky_2000_Behav.Brain.Res_115_143Local synaptic connections of basal forebrain neurons
Zaccaria_2000_J.Neuropathol.Exp.Neurol_59_103Selective reduction in the nicotinic acetylcholine receptor and dystroglycan at the postsynaptic apparatus of mdx mouse superior cervical ganglion
Zaitsu_2000_Blood_96_601New induction of leukotriene A(4) hydrolase by interleukin-4 and interleukin-13 in human polymorphonuclear leukocytes
Zajc_2000_Pflugers.Arch_439_R66Nonradioactive northern blotting for the determination of acetylcholinesterase mRNA. Comparison to the radioactive technique
Zaltsman_2000_Br.J.Pharmacol_130_315Rapid desensitization of the TRH receptor and persistent desensitization of its constitutively active mutant
Zanella_2000_Pest.Manag.Sci_56_804Determination of carbofuran in pesticide formulations by flow injection spectrophotometry
Zaninetti_2000_Neurosci_100_589Nicotinic acetylcholine receptors in neonatal motoneurons are regulated by axotomy: an electrophysiological and immunohistochemical study in human bcl-2 transgenic mice
Zaninetti_2000_Neurosci_95_319Magnocellular neurons of the rat supraoptic nucleus are endowed with functional nicotinic acetylcholine receptors
Zapata_2000_Synapse_35_272Role of high-affinity choline uptake on extracellular choline and acetylcholine evoked by NMDA
Zavodnik_2000_Biochemistry.(Mosc)_65_946Hypochlorous acid-induced lysis of human erythrocytes. Inhibition of cellular damage by the isoflavonoid genistein-8-C-glucoside
Zhai_2000_Mol.Cell.Neurosci_15_417Temporal appearance of the presynaptic cytomatrix protein bassoon during synaptogenesis
Zhang_2000_Brain.Res_868_157Epitopes of human brain acetylcholinesterase
Zhang_2000_Brain.Res_876_1032-deoxyglucose induces LTP in layer I of rat somatosensory cortex in vitro
Zhang_2000_Genome.Res_10_1546Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells
Zhang_2000_J.Neurochem_75_1294Insect nicotinic acetylcholine receptor: conserved neonicotinoid specificity of [(3)H]imidacloprid binding site
Zhang_2000_Neurosci.Lett_290_21Effects of a traditional Chinese medicine, Qing Nao Yi Zhi Fang, on glutamate excitotoxicity in rat fetal cerebral neuronal cells in primary culture
Zhang_2000_Neurosci.Lett_292_41Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells
Zhang_2000_Neurosci.Lett_295_116Similar potency of the enantiomers of huperzine A in inhibition of [(3)H]dizocilpine (MK-801) binding in rat cerebral cortex
Zhang_2000_Zhongguo.Zhong.Xi.Yi.Jie.He.Za.Zhi_20_43[Experimental study on effect of bushen yijing recipe in delaying senility of bone and brain of aged male rats]
Zhao_2000_Development_127_1253A retrograde signal is involved in activity-dependent remodeling at a C. elegans neuromuscular junction
Zhao_2000_J.Neurophysiol_83_1772-Deoxyglucose-induced long-term potentiation in CA1 is not prevented by intraneuronal chelator
Zhao_2000_Zhonghua.Nei.Ke.Za.Zhi_39_653[Characters of cholinesterase are correlated with acute organophosphorus pesticide poisoning]
Zheng_2000_Hear.Res_143_115Metabolism of the dorsal cochlear nucleus in rat brain slices
Zheng_2000_Toxicol.Sci_55_124Comparative cholinergic neurotoxicity of oral chlorpyrifos exposures in preweanling and adult rats
Zholos_2000_Br.J.Pharmacol_129_695Voltage-dependent inhibition of the muscarinic cationic current in guinea-pig ileal cells by SK&F 96365
Zholos_2000_J.Physiol_528_521Membrane currents in cultured human intestinal smooth muscle cells
Zhong_2000_Neurogenetics_3_41CLN-encoded proteins do not interact with each other
Zhong_2000_Zhonghua.Nei.Ke.Za.Zhi_39_658[Alteration of banked blood cholinesterase level and its significance in emergency treatment of acute organophosphorus pesticide poisoning]
Zhou_2000_Brain.Res_866_268Developmental stage-dependent protective effect of NGF against lead cholinotoxicity in the rat septum
Zhu_2000_Exp.Neurol_166_136Postinjury administration of L-deprenyl improves cognitive function and enhances neuroplasticity after traumatic brain injury
Zhu_2000_Pestic.Biochem.Physiol_67_155Elevated Esterases Exhibiting Arylesterase-like Characteristics in an Organophosphate-Resistant Clone of the Greenbug, Schizaphis graminum (Homoptera: Aphididae)
Zhu_2000_Pestic.Biochem.Physiol_68_138Organophosphate Resistance Mediated by Alterations of Acetylcholinesterase in a Resistant Clone of the Greenbug, Schizaphis graminum (Homoptera: Aphididae)
Zia_2000_J.Pharmacol.Exp.Ther_293_973Receptor-mediated inhibition of keratinocyte migration by nicotine involves modulations of calcium influx and intracellular concentration
Zocher_2000_J.Biotechnol_77_287Epoxide hydrolase activity of Streptomyces strains
Zoli_2000_Handb.Exp.Pharmacol_144_13Distribution of Cholinergic Neurons in the Mammalian Brain with Special Reference to their Relationship with Neuronal Nicotinic Acetylcholine Receptors
Zoli_2000_Handb.Exp.Pharmacol_144_213Neuronal Nicotinic Acetylcholine Receptors in Development and Aging
Zou_2000_Structure.Fold.Des_8_111Structure of Aspergillus niger epoxide hydrolase at 1.8 A resolution: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases
Zubaran_2000_Behav.Pharmacol_11_431The development and expression of locomotor sensitization to nicotine in the presence of ibogaine
Zwart_2000_Eur.J.Pharmacol_393_209Potentiation and inhibition of neuronal alpha4beta4 nicotinic acetylcholine receptors by choline
Zwart_2000_J.Neurochem_75_2492Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acetylcholinesterase-inhibiting drugs
de Blaquiere_2000_Toxicol.Appl.Pharmacol_166_81Electrophysiological and biochemical effects of single and multiple doses of the organophosphate diazinon in the mouse
de Castro_2000_Toxicol.Lett_118_93Relevance of developmental testing of exposure to methamidophos during gestation to its toxicology evaluation
de Martino_2000_Dev.Dyn_217_279Expression of sox11 gene duplicates in zebrafish suggests the reciprocal loss of ancestral gene expression patterns in development
de Vries_2000_Carbohydr.Res_327_401Synergy between enzymes from Aspergillus involved in the degradation of plant cell wall polysaccharides
de la Torre_2000_Environ.Pollut_109_277Biomarkers assessment in juvenile Cyprinus carpio exposed to waterborne cadmium
van Dyck_2000_Arch.Gen.Psychiatry_57_157Extended-release physostigmine in Alzheimer disease: a multicenter, double-blind, 12-week study with dose enrichment. Physostigmine Study Group
van Mierlo_2000_J.Biotechnol_79_281Protein folding and stability investigated by fluorescence, circular dichroism (CD), and nuclear magnetic resonance (NMR) spectroscopy: the flavodoxin story
van Pee_2000_Biol.Chem_381_1Enzymatic halogenation catalyzed via a catalytic triad and by oxidoreductases
van den Brink_2000_Mol.Gen.Genet_263_601Regulation of expression of the Aspergillus niger benzoate para-hydroxylase cytochrome P450 system


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