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Type_substrate Report for: Pro-Drug

A prodrug is a medication or compound that, after administration, is metabolized (i.e., converted within the body) into a pharmacologically active drug. For example, salicin is a beta-D-glucopyranoside that is cleaved by esterases to release salicylic acid. Aspirin, acetylsalicylic acid, first made by Felix Hoffmann at Bayer in 1897, is a synthetic prodrug of salicylic acid. Many prodrugs are synthetized to slow down the delivery of the active compound. Esterases often hydrolyze prodrugs and are targeted for that role. Genetic variants of these esterases may act differently and explain variation of response in patients bearing these variant
See also this moiety in type of inhibitors: Pro-Drug

SubstrateMain targeted enzyme familiesTypeStructure
2-oxo-clopidogrelCarb_B_Chordata Acetate | Drug | Not A/B H target | Pro-Drug | Pyridine
Abiraterone-acetateArylacetamide_deacetylase Drug | Not A/B H target | Phenanthrene | Pro-Drug | Pyridine
AcebutololCarb_B_Chordata Drug | Not A/B H target | Pro-Drug
AnordrinCarb_B_Chordata Drug | Pro-Drug | Propionate
Baloxavir-marboxilArylacetamide_deacetylase Drug | Not A/B H target | Pro-Drug | Sulfur compound
BambuterolBCHE Adrenergic-Receptor-ligand | Carbamate | Drug | Pro-Drug | tert-Butyl
Beclomethasone-dipropionateArylacetamide_deacetylase Drug | Not A/B H target | Phenanthrene | Pro-Drug | Propionate | Steroid
BemnifosbuvirCarb_B_Chordata | Carboxypeptidase_S10 Drug | Not A/B H target | Pro-Drug | Propionate | Purine
CHEMBL1784957ACHE Carbamate | Derivative of Rivastigmine | Drug | Pro-Drug
Candesartan-cilexetilCarb_B_Chordata Angiotensin-receptor blocker | Drug | Not A/B H target | Pro-Drug | Pyrrolidine
CapecitabineCarb_B_Chordata | Carboxylesterase Carbamate | Drug | Pro-Drug | Pyrimidine
CiclesonideBCHE | Carb_B_Chordata Butyrate | Drug | Not A/B H target | Pro-Drug
Clevidipine Butyrate | Drug | Not A/B H target | Pro-Drug
ClofibrateCarb_B_Chordata Drug | Not A/B H target | Pro-Drug | Propionate
CurDDBCHE | CMBL | Carb_B_Chordata Drug | Natural_modified | Pro-Drug
Dabigatran-etexilateCarb_B_Chordata Benzimidazole | Drug | Not A/B H target | Pro-Drug | Propionate | Pyridine
Dimethyl-fumarateCarb_B_Chordata Drug | Not A/B H target | Pro-Drug
DipivefrinACHE | BCHE | Carb_B_Chordata Drug | Not A/B H target | Pro-Drug | Propionate
EnalaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Not A/B H target | Pro-Drug | Pyrrolidine
Eslicarbazepine-acetateArylacetamide_deacetylase | Carb_B_Chordata Acetate | Benzazepin | Carbamate | Carboxamide | Drug | Pro-Drug
Ethyl-CarprofenHormone-sensitive_lipase_like Alkyl ester | Carbazol | Drug | Not A/B H target | Pro-Drug | Propionate
Ethyl-FlurbiprofenBacterial_lip_FamI.3 | Canar_LipB | Hormone-sensitive_lipase_like Alkyl ester | Drug | Not A/B H target | Pro-Drug | Propionate
Ethyl-ZaltoprofenBacterial_lip_FamI.3 | Hormone-sensitive_lipase_like Alkyl ester | Drug | Not A/B H target | Pro-Drug | Propionate
FenofibrateCarb_B_Chordata Drug | Pro-Drug | Propionate
FlupirtineCarb_B_Chordata Carbamate | Drug | Not A/B H target | Pro-Drug
FosinoprilCarb_B_Chordata | Plasmodium_subtelomeric_PST-A Angiotensin-converting enzyme inhibitor | Drug | Not A/B H target | Organophosphate | Pro-Drug | Pyrrolidine
Ibuprofen-Ethyl-EsterHormone-sensitive_lipase_like Drug | Pro-Drug | Profen prodrug | Propionate
Idalopirdine-rivastigmineBCHE 5-HT-receptor-ligand | Carbamate | Derivative of Rivastigmine | Drug | Indole | Multitarget | Pro-Drug
ImidaprilCarb_B_Chordata Drug | Not A/B H target | Pro-Drug
IndiplonArylacetamide_deacetylase Drug | Not A/B H target | Pro-Drug | Pyrazole | Pyrimidine | Sulfur compound
Isosorbide-2,5-diaspirinateBCHE Acetate | Benzoate | Drug | Isosorbide | Pro-Drug | Salicylic
Isosorbide-2-aspirinateBCHE Acetate | Benzoate | Drug | Isosorbide | Pro-Drug | Salicylic
Isosorbide-2-aspirinate-5-mononitrateBCHE Isosorbide | Pro-Drug | Salicylic
Isosorbide-2-aspirinate-5-salicylateBCHE | Carb_B_Chordata Acetate | Benzoate | Isosorbide | Pro-Drug | Salicylic
KetoconazoleArylacetamide_deacetylase Dioxolane | Drug | Imidazole | Not A/B H target | Piperazine | Pro-Drug
Ketoprofen-Butyl-EsterCanar_LipB Aryl ester | Drug | Pro-Drug | Profen prodrug | Propionate
Ketoprofen-Ethyl-EsterBacterial_lip_FamI.3 | Canar_LipB | CarbLipBact_1 | Hormone-sensitive_lipase_like | Lipase_2 Aryl ester | Drug | Pro-Drug | Profen prodrug | Propionate
Ketoprofen-Glycerol-EsterCanar_LipB Drug | Pro-Drug | Profen prodrug | Propionate
Ketoprofen-Vinyl-EsterCanar_LipB Aryl ester | Drug | Pro-Drug | Profen prodrug | Propionate
MGS0274Carb_B_Chordata Drug | Not A/B H target | Pro-Drug
MolnupiravirBCHE | Carb_B_Chordata Drug | Not A/B H target | Nucleoside | Pro-Drug | Propionate
Mycophenolate-mofetilCarb_B_Chordata Benzofuran | Drug | Morpholine | Not A/B H target | Pro-Drug
NT-0796Carb_B_Chordata | Carboxylesterase Drug | Indacen | Not A/B H target | Pro-Drug | Pyrimidine
Naproxen-Ethyl-Ester6_AlphaBeta_hydrolase | Canar_LipB | Hormone-sensitive_lipase_like Drug | Naphthalen | Pro-Drug | Profen prodrug | Propionate
Naproxen-Methyl-Ester6_AlphaBeta_hydrolase | Hormone-sensitive_lipase_like Drug | Naphthalen | Pro-Drug | Profen prodrug | Propionate
NintedanibCarb_B_Chordata Drug | Not A/B H target | Piperazine | Pro-Drug
NitroaspirinBCHE Pro-Drug | Salicylic
OseltamivirBCHE | Carb_B_Chordata Drug | Not A/B H target | Pro-Drug
QA-CblBCHE Choline ester | Drug | Pro-Drug
QuinaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Isoquinoline | Not A/B H target | Pro-Drug
RemdesivirCarb_B_Chordata | Carboxypeptidase_S10 Drug | Not A/B H target | Pro-Drug | Propionate | Triazine
RifabutinArylacetamide_deacetylase Antibiotic | Drug | Not A/B H target | Piperidine | Pro-Drug
RifapentineArylacetamide_deacetylase Antibiotic | Drug | Not A/B H target | Piperazine | Pro-Drug
S-bromobenzylglutathione-dicyclopentyl-esterCarb_B_Chordata Drug | Not A/B H target | Peptide | Pro-Drug | Sulfur compound
SacubitrilCarb_B_Chordata Drug | Not A/B H target | Oxobutanoate | Pro-Drug
SelexipagCarb_B_Chordata Drug | Not A/B H target | Pro-Drug | Sulfonyl | Sulfur compound
SirpiglenastatCarb_B_Chordata Drug | Peptide | Pro-Drug
TemocaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Azepane | Drug | Not A/B H target | Pro-Drug
Tenofovir-alafenamideCarb_B_Chordata | Carboxypeptidase_S10 Aminopurin | Drug | Pro-Drug | Propionate
TrandolaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Not A/B H target | Pro-Drug | Pyrrolidine
VixotrigineCarb_B_Chordata Crboxamide | Drug | Not A/B H target | Pro-Drug | Pyrrolidine
W22-methyl-esterBacterial_esterase | Canar_LipB Benzodiazepin | Drug | Not A/B H target | Pro-Drug

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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