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Type_substrate Report for: Not A/B H target

Substrates or inhibitors which are not primarily found or designed to be ligand of any alpha/beta hydrolases. Some Alpha/beta hydrolases can be considered as off targets of these compounds
See also this moiety in type of inhibitors: Not A/B H target

SubstrateMain targeted enzyme familiesTypeStructure
2,4-D-Butyl-esterLipase_2 Herbicide | Not A/B H target
2,4-D-MethylPlant_carboxylesterase Herbicide | Not A/B H target
2-oxo-clopidogrelCarb_B_Chordata Acetate | Drug | Not A/B H target | Pro-Drug | Pyridine
ADP-ribosePlant_lipase_EDS1-like Aminopurin | Drug | Not A/B H target
AZD1979Epoxide_hydrolase Azaspiro | Azetidin | Not A/B H target | Oxadiazol
Amplex-redCarb_B_Chordata Derivative of Resorufin | Fluorescent Probe | Not A/B H target | Phenoxazin
Beclomethasone-dipropionateArylacetamide_deacetylase Drug | Not A/B H target | Pro-Drug | Propionate | Steroid
BenzoylecgonineBCHE | Cocaine_esterase Alkaloid | Drug | Not A/B H target
CarbacholACHE Analogue of substrate | Carbamate | Choline ester | Drug | Not A/B H target | Trimethylammonium
CiclesonideCarb_B_Chordata Butyrate | Drug | Not A/B H target | Pro-Drug
ClopidogrelCarb_B_Chordata Drug | Not A/B H target | Pyridine
CyflumetofenCholinesterase-like Acaricide | Cyanide | Not A/B H target | Propionate
Cypermethrin6_AlphaBeta_hydrolase | Carb_B_Arthropoda | Carb_B_Chordata | LYsophospholipase_carboxylesterase Cyanide | Cyclopropane | Insecticide | Not A/B H target | Phenoxyphenyl | pyrethroid
DTS-108Carb_B_Chordata | Carboxylesterase Drug | Not A/B H target | Peptide
Dabigatran-etexilateCarb_B_Chordata Benzimidazole | Drug | Not A/B H target | Pro-Drug | Propionate | Pyridine
DiltiazemCarb_B_Chordata Calcium Channel Antagonist | Drug | Not A/B H target
Dimethyl-fumarateCarb_B_Chordata Drug | Not A/B H target | Pro-Drug
DipivefrinACHE | BCHE | Carb_B_Chordata Drug | Not A/B H target | Pro-Drug | Propionate
EnalaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Not A/B H target | Pro-Drug | Pyrrolidine
EsmololCarb_B_Chordata | LYsophospholipase_carboxylesterase Drug | Not A/B H target | Propionate
Ethyl-CarprofenHormone-sensitive_lipase_like Alkyl ester | Carbazol | Drug | Not A/B H target | Pro-Drug | Propionate
Ethyl-FlurbiprofenBacterial_lip_FamI.3 | Canar_LipB | Hormone-sensitive_lipase_like Alkyl ester | Drug | Not A/B H target | Pro-Drug | Propionate
Ethyl-ZaltoprofenBacterial_lip_FamI.3 | Hormone-sensitive_lipase_like Alkyl ester | Drug | Not A/B H target | Pro-Drug | Propionate
FenpropathrinCarb_B_Arthropoda Acaricide | Cyanide | Cyclopropane | Insecticide | Not A/B H target | Phenoxyphenyl | pyrethroid
HomatropineA85-Mycolyl-transferase | Carb_B_Chordata Drug | Not A/B H target
ImidaprilCarb_B_Chordata Drug | Not A/B H target | Pro-Drug
IndoxacarbCarb_B_Arthropoda Carbamate | Carboxamide | Insecticide | Not A/B H target | Trifluo
IomazenilCarb_B_Chordata Benzodiazepin | Drug | Not A/B H target
IsobucaineBCHE Local anesthetic | Not A/B H target
LidocaineCarb_B_Chordata | Carboxylesterase Drug | Local anesthetic | Not A/B H target
MGS0274Carb_B_Chordata Drug | Not A/B H target | Pro-Drug
MeperidineBCHE | Carb_B_Chordata | Carboxylesterase Drug | Not A/B H target | Opioid analgesic | Piperidine
MeprylcaineBCHE Local anesthetic | Not A/B H target
MethylphenidateCarb_B_Chordata Drug | Not A/B H target | Piperidine
MivacuriumBCHE Bisquaternary | Drug | Isoquinoline | Neuromuscular Nondepolarizing Agents | Not A/B H target
MolnupiravirCarb_B_Chordata Drug | Not A/B H target | Pro-Drug | Propionate
Mycophenolic-acid-acyl-glucuronideABHD10 Benzofuran | Drug | Glucuronide | Glucuronoyl | Lactone | Not A/B H target
NPCCarb_B_Bacteria Carbamate | Derivative of Irinotecan | Drug | Not A/B H target | Piperidine
Olmesartan-medoxomilCMBL Not A/B H target | Tetrazol
OseltamivirCarb_B_Chordata Drug | Not A/B H target | Pro-Drug
PAFLYsophospholipase_carboxylesterase | PAF-Acetylhydrolase Choline ester | Natural | Not A/B H target | Trimethylammonium | Water-insoluble medium and long chain ester
PermethrinCarb_B_Arthropoda | Carb_B_Bacteria | Carb_B_Chordata | Carboxylesterase Cyclopropane | Drug | Insecticide | Not A/B H target | Phenoxyphenyl | pyrethroid
Phenytoin Not A/B H target
PrasugrelArylacetamide_deacetylase | Carb_B_Chordata Acetate | Cyclopropane | Drug | Not A/B H target
Probenecid-glucuronideABHD10 Drug | Glucuronide | Lactone | Not A/B H target
ProcaineBCHE Drug | Local anesthetic | Not A/B H target
QuinaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Isoquinoline | Not A/B H target | Pro-Drug
RedGreen-BODIPY-PC-A2 BODIPY-derivative | Boron compound | Choline ester | Fluorescent Probe | Not A/B H target
RemdesivirCarb_B_Chordata | Carboxypeptidase_S10 Drug | Not A/B H target | Pro-Drug | Propionate | Triazine
RemifentanilCarb_B_Chordata | Carboxylesterase Drug | Not A/B H target | Opioid analgesic
RemimazolamCarb_B_Chordata Benzodiazepin | Drug | Not A/B H target | Propionate
RifampicinArylacetamide_deacetylase Acetate | Antibiotic | Drug | Natural | Not A/B H target
RufinamideCarb_B_Chordata Carboxamide | Drug | Not A/B H target | Triazol
S-bromobenzylglutathione-dicyclopentyl-esterCarb_B_Chordata Drug | Not A/B H target | Peptide | Pro-Drug | Sulfur Compound
SacubitrilCarb_B_Chordata Drug | Not A/B H target | Oxobutanoate | Pro-Drug
SelexipagCarb_B_Chordata Drug | Not A/B H target | Pro-Drug
SimvastatinCarb_B_Chordata Drug | Naphthalen | Not A/B H target
TemocaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Azepane | Drug | Not A/B H target | Pro-Drug
TrandolaprilCarb_B_Chordata Angiotensin-converting enzyme inhibitor | Drug | Not A/B H target | Pro-Drug | Pyrrolidine
VicagrelArylacetamide_deacetylase | Carb_B_Chordata Acetate | Drug | Not A/B H target | Pyridine
W22-methyl-esterBacterial_esterase | Canar_LipB Benzodiazepin | Drug | Not A/B H target | Pro-Drug
trans-BifenthrinCarb_B_Arthropoda | HNLyase_Bact Carbamate | Cyclopropane | Insecticide | Not A/B H target | Trifluoro | pyrethroid
Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
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