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Type_substrate Report for: Macrocycle

Macrocycles are molecules containing a ring of twelve or more atoms. The formation of macrocycles by ring-closure is called macrocylization.Cylisation of peptides enhances their proteolytic stability, membrane permeability and target selectivity Some macrocyles peptides have antibiotic or antifungal activity and are used as pharmaceutical drugs
See also this moiety in type of inhibitors: Macrocycle

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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