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Type_inhibitor Report for: anti-Abeta-aggregation

The main neuropathological feature of Alzhzimer's disease consist in extracellular amyloid-beta (A/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. Acetylcholinesterase is also thought to promote the aggregation. The peripheral anionic site on the surface participate in this process

InhibitorMain targeted enzyme familiesTypeStructure
Ass-IN-10BCHE Alkyl linked bis-ligand | BACE1-inhibitor | Multitarget | anti-Abeta-aggregation | anti-tau-aggregation | tert-Butyl
BIGI-3hACHE | BCHE Calcium Channel Antagonist | Derivative of Donepezil | GSK-3 kinase inhibitor | Monoamine-oxidase-inhibitor | Multitarget | anti-Abeta-aggregation
CHEMBL5206601ACHE Multitarget | Pyridine | anti-Abeta-aggregation
Chlorotacrine-jugloneACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Naphthalen | anti-Abeta-aggregation
Chlorotacrine-tryptophan-hybridACHE | BCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation
Compound19n-quinolinolACHE Derivative of Donepezil | Metal ion chelator | Multitarget | Quinoline | Trifluo | anti-Abeta-aggregation
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiolACHE BACE1-inhibitor | Carboxamide | Cyanide | Derivative of Donepezil | Multitarget | Oxadiazol | Piperidine | Sulfur Compound | anti-Abeta-aggregation
Cpd17-Tacrine-5-HT6ACHE | BCHE 5-HT-receptor-ligand | Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | Sulfonamide | Sulfur Compound | anti-Abeta-aggregation
Cpd35-Rivastigmine-5-HT6BCHE 5-HT-receptor-ligand | Alkyl linked bis-ligand | Carbamate | Derivative of Rivastigmine | Indole | Multitarget | Sulfonamide | Sulfur Compound | anti-Abeta-aggregation
Donepezil-idebenone-cpd9BCHE Antioxidant | Derivative of Donepezil | Multitarget | anti-Abeta-aggregation
Genistein-O-alkylbenzylamine-25dACHE Monoamine-oxidase-inhibitor | Multitarget | anti-Abeta-aggregation
MTDL-cpd36-diphenylacetamideBCHE BACE1-inhibitor | Diphenylacetamide | GABA-transporter-inhibitor | Multitarget | anti-Abeta-aggregation | tert-Butyl
MTDL-cpd51-diphenylacetamideBCHE BACE1-inhibitor | Diphenylacetamide | GABA-transporter-inhibitor | Multitarget | anti-Abeta-aggregation
Phenothiazine-Tacrine-1dCACHE Acridine | Alkyl linked bis-ligand | Antioxidant | Derivative of Tacrine | Multitarget | Phenothiazine | Sulfur Compound | anti-Abeta-aggregation
Quinolinetrione-tacrine-Cpd3ACHE Acridine | Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | Quinoline | anti-Abeta-aggregation
Tacrine-dipicolylamine-13aACHE Alkyl linked bis-ligand | Derivative of Tacrine | Multitarget | anti-Abeta-aggregation
Tetracyclic-triterpene-36eACHE Natural_modified | Sulfur Compound | Terpenoid | anti-Abeta-aggregation
tacrine-isatin-Cpd7dBCHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation
tacrine-isatin-Cpd7kACHE Alkyl linked bis-ligand | Derivative of Tacrine | Indole | Multitarget | anti-Abeta-aggregation

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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