Type Inhibitor

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Type_inhibitor Report for: Urea derivative

Urea, also known as carbamide, is an organic compound with chemical formula CO(NH2)2. Building block for many inhibitors of enzymes

Inhibitor	Main targeted enzyme families	Type

(4-fluoroanilino)thiourea	Pectinacetylesterase-Notum	Fragment inhibitor of Notum \| Sulfur compound \| Urea derivative

1,3-Dibenzylurea	Epoxide_hydrolase	Natural \| Urea derivative

1,3-Dicyclohexylurea	Epoxide_hydrolase	Urea derivative

4-(3-cyclohexyluriedo)-butyric-acid	Epoxide_hydrolase	Urea derivative

4-(3-cyclohexyluriedo)-ethanoic-acid	Epoxide_hydrolase	Urea derivative

4-(3-cyclohexyluriedo)-heptanoic-acid	Epoxide_hydrolase	Urea derivative

4-(3-cyclohexyluriedo)-hexanoic-acid	Epoxide_hydrolase	Urea derivative

5ALI-Q3B	Epoxide_hydrolase	Imidazole \| Pyrimidine \| Urea derivative

5ALU-HD2	Epoxide_hydrolase	Adamantyl \| Carboxamide \| Not A/B H target \| Pyrimidine \| Urea derivative

5ALZ-XQ9	Epoxide_hydrolase	Adamantyl \| Piperidine \| Sulfonamide \| Sulfonyl \| Sulfur compound \| Urea derivative

6H12-(R)2	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative

6H13-(R)3	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative

6H14-(S)6	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative \| beta-carboline

6N3K-1	Epoxide_hydrolase	Urea derivative

6N3Z-4	Epoxide_hydrolase	Trifluoro \| Urea derivative

6N5G-2	Epoxide_hydrolase	Carboxamide \| Urea derivative

7-methoxytacrine-memantine-Cpd4	ACHE	Adamantyl \| Alkyl linked bis-ligand \| Multitarget \| NMDA-ligand \| Urea derivative

AAF	DPP4N_Peptidase_S9	Benzoate \| Pyrrolidine \| Urea derivative

AEPU	Epoxide_hydrolase	Adamantyl \| Urea derivative

AL237	ACHE	Sulfur compound \| Urea derivative

AM6580	Monoglyceridelipase_lysophospholip	Fluoren \| Piperazine \| Urea derivative

AM6701	ABHD6-Lip \| Monoglyceridelipase_lysophospholip	Biphenyl \| Cannabinoid-Receptor-ligand \| Carboxamide \| FAAH inhibitor \| Multitarget \| Tetrazol \| Urea derivative

AUDA	Epoxide_hydrolase	Adamantyl \| Dodecanoate \| Urea derivative

Adamantyl-urea-Cpd28	Epoxide_hydrolase	Adamantyl \| Urea derivative

Ar9281	Epoxide_hydrolase	Adamantyl \| Urea derivative

Atglistatin	Carb_B_Chordata	Biphenyl \| Urea derivative

B401	Epoxide_hydrolase	Adamantyl \| Piperidine \| Urea derivative

BAY	Hormone-sensitive_lipase_like	Piperidine \| Urea derivative

CDU	Epoxide_hydrolase	Urea derivative

CHEMBL1615216	Epoxide_hydrolase	Carboxamide \| Cyclopropyl \| Oxadiazol \| Piperidine \| Urea derivative

CHEMBL1818384	Epoxide_hydrolase	Adamantyl \| Urea derivative

CHEMBL3114611	Epoxide_hydrolase	Carboxamide \| Cyclopropyl \| Piperidine \| Urea derivative

CHEMBL3401634	Epoxide_hydrolase	Cyclopropyl \| Urea derivative

CHEMBL3633668	Epoxide_hydrolase	Adamantyl \| Urea derivative

CIU	Epoxide_hydrolase	Urea derivative

CPU	Epoxide_hydrolase	Urea derivative

DH376	Lipase_3	Piperidine \| Triazol \| Urea derivative

DO264	ABHD12-PHARC	Sulfur compound \| Urea derivative

Dihydroindole-thiourea-73	Epoxide_hydrolase	5-Lipoxygenase inhibitor \| Indole \| Multitarget \| Sulfur compound \| Urea derivative

Diphenylurea	Epoxide_hydrolase	Urea derivative

Diuron	ACHE \| Epoxide_hydrolase	Herbicide \| Not A/B H target \| Urea derivative

EC5026	Epoxide_hydrolase	Piperidine \| Trifluoro \| Urea derivative

Eprotirome	CFTR-inhibitory-factor_Cif	Drug \| Thyroid hormone analogue \| Urea derivative

Fragment-049-notum-screen	Pectinacetylesterase-Notum	Fragment inhibitor of Notum \| Urea derivative

Fragment-063-notum-screen	Pectinacetylesterase-Notum	Benzoxadiazole \| Fragment inhibitor of Notum \| Urea derivative

Fragment-064-notum-screen	Pectinacetylesterase-Notum	Fragment inhibitor of Notum \| Urea derivative

Fragment-110	Pectinacetylesterase-Notum	Fragment inhibitor of Notum \| Pyridine \| Urea derivative

Fragment-828	Pectinacetylesterase-Notum	Fragment inhibitor of Notum \| Urea derivative

GSK-264220A	Lipoprotein_Lipase	Sulfonamide \| Sulfur compound \| Urea derivative

GSK2256294A	Epoxide_hydrolase	Carboxamide \| Cyanide \| Triazine \| Urea derivative

Imidocarb		Drug \| Urea derivative

Isatin-thiosemicarbazone-cpd13	ACHE \| BCHE	Indole \| Urea derivative

JCP276		Coumarin \| Urea derivative

KK023-N1	RsbQ-like	Strigolactone receptors ligand \| Triazol \| Urea derivative

KK023-N2	RsbQ-like	Strigolactone receptors ligand \| Triazol \| Urea derivative

KK052	RsbQ-like	Piperazine \| Triazol \| Urea derivative

KK073	RsbQ-like	Triazol \| Trifluoro \| Urea derivative

KK094	RsbQ-like	Strigolactone receptors ligand \| Triazol \| Urea derivative

KT129	A85-EsteraseD-FGH	Triazol \| Urea derivative

KT130	A85-EsteraseD-FGH	Triazol \| Urea derivative

LF-14	ACHE	Pyridine \| Urea derivative

LK864	Epoxide_hydrolase	Azaspiro \| Sulfur compound \| Trifluoro \| Urea derivative

LY2183240	ABHD6-Lip \| Arylacetamide_deacetylase \| Monoglyceridelipase_lysophospholip	Biphenyl \| Cannabinoid-Receptor-ligand \| Carboxamide \| FAAH inhibitor \| Multitarget \| Tetrazol \| Urea derivative

ML225	PAF-Acetylhydrolase	Pyrrolidine \| Triazol \| Urea derivative

MMU	Epoxide_hydrolase	Natural \| Urea derivative

Morpholino-Talinolol	Epoxide_hydrolase	Adrenergic-Receptor-ligand \| Morpholine \| Not A/B H target \| Urea derivative \| tert-Butyl

N-1-adamantyl-N'-cyclohexylurea	Epoxide_hydrolase	Adamantyl \| Urea derivative

PTUPB	Epoxide_hydrolase	Multitarget \| Pyrazole \| Sulfonamide \| Sulfur compound \| Trifluoro \| Urea derivative

Piperidinyl-1,2,3-triazole-urea-inhibitor-11	LYsophospholipase_carboxylesterase	Piperidine \| Triazol \| Urea derivative

Piperidinyl-1,2,3-triazole-urea-inhibitor-12	LYsophospholipase_carboxylesterase	Piperidine \| Triazol \| Urea derivative

Piperidinyl-1,2,3-triazole-urea-inhibitor-2	ABHD11-Acetyl_transferase \| Carb_B_Chordata \| Cholesterol_esterase \| LYsophospholipase_carboxylesterase \| PAF-Acetylhydrolase	Piperidine \| Triazol \| Urea derivative

Regorafenib	Epoxide_hydrolase	Carboxamide \| Not A/B H target \| Trifluoro \| Urea derivative \| multi-kinase inhibitor

SCHEMBL15272467	Epoxide_hydrolase	Piperidine \| Trifluoro \| Urea derivative

SCHEMBL19358888	Epoxide_hydrolase	Benzoate \| FAAH inhibitor \| Multitarget \| Urea derivative

SCHEMBL22462761	Monoglyceridelipase_lysophospholip	Azetidin \| PET probe \| Trifluoro \| Urea derivative

SR-3420	CGI-58_ABHD5_ABHD4	Benzothiazepin \| Sulfur compound \| Trifluoro \| Urea derivative

SR-4995	CGI-58_ABHD5_ABHD4	Benzothiazepin \| Sulfur compound \| Urea derivative

Sorafenib	Epoxide_hydrolase	Carboxamide \| Not A/B H target \| Trifluoro \| Urea derivative \| multi-kinase inhibitor

TPPU	Epoxide_hydrolase	Piperidine \| Trifluoro \| Urea derivative

TPPU-6-Chlorotacrine-12c	ACHE \| Epoxide_hydrolase	Alkyl linked bis-ligand \| Derivative of Tacrine \| Multitarget \| Piperidine \| Trifluoro \| Urea derivative

TPPU-methyl	Epoxide_hydrolase	Piperidine \| Trifluoro \| Urea derivative

TUPS	Epoxide_hydrolase	Piperidine \| Sulfonamide \| Sulfur compound \| Trifluoro \| Urea derivative

Talinolol	Epoxide_hydrolase	Adrenergic-Receptor-ligand \| Not A/B H target \| Urea derivative

Tiratricol-derivative-8c	CFTR-inhibitory-factor_Cif	Carboxamide \| Thyroid hormone analogue \| Urea derivative

Tiratricol-derivative-8h	CFTR-inhibitory-factor_Cif	Thyroid hormone analogue \| Urea derivative

Tr-EH-urea-13	Epoxide_hydrolase	Trifluoro \| Urea derivative

UB-EV-52	Epoxide_hydrolase	Adamantyl \| Urea derivative

ZINC10109382-S0A-3WK4	Epoxide_hydrolase	Cyclopropyl \| Urea derivative

ZINC1603176-7WI-4C4Y	Epoxide_hydrolase	Urea derivative

ZINC395065-W9L-4C4Z	Epoxide_hydrolase	Naphthalen \| Urea derivative

nbAUDA	Epoxide_hydrolase	Adamantyl \| Dodecanoate \| Urea derivative

sEH-LTA4H-14	Epoxide_hydrolase	LTA4-hydrolase-inhibitor \| Multitarget \| Sulfur compound \| Urea derivative

t-AUCB	Epoxide_hydrolase	Adamantyl \| Urea derivative

t-AUCMB	Epoxide_hydrolase	Adamantyl \| Multitarget \| Urea derivative

t-MTUCB	Epoxide_hydrolase	Multitarget \| Urea derivative

t-MTUCB-NH	Epoxide_hydrolase	Multitarget \| Urea derivative

t-TUCB	Epoxide_hydrolase	FAAH inhibitor \| Multitarget \| Urea derivative

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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