Type Inhibitor

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Type_inhibitor Report for: Sulfonamide

Sulfonamide (sulphonamide) is an organosulfur group with the structure RS(=O)2NR2. It consists of a sulfonyl group (O=S=O) connected to an amine group (NH2). Building block for many inhibitors of enzymes

Inhibitor	Main targeted enzyme families	Type

2-allyl-4-oxocyclobutyl-4-methylbenzenesulfonamide	LYsophospholipase_carboxylesterase	Sulfonamide \| Sulfur Compound

3-cyano-N-cyclopropylbenzenesulfonamide	PAF-Acetylhydrolase	Cyanide \| Cyclopropyl \| Sulfonamide \| Sulfur Compound

5ALH-4UA	Epoxide_hydrolase	Carboxamide \| Piperidine \| Sulfonamide \| Sulfonyl \| Sulfur Compound

5ALZ-XQ9	Epoxide_hydrolase	Adamantyl \| Piperidine \| Sulfonamide \| Sulfonyl \| Sulfur Compound \| Urea derivative

5DYT-5hb	BCHE	Derivative of Donepezil \| Naphthalen \| Piperidine \| Sulfonamide \| Sulfur Compound

5DYW-5hf	BCHE	Derivative of Donepezil \| Naphthalen \| Piperidine \| Sulfonamide \| Sulfur Compound

5DYW-5hf-C11	BCHE	Derivative of Donepezil \| Naphthalen \| PET probe \| Piperidine \| Sulfonamide \| Sulfur Compound

5DYW-5hf-F	BCHE	Derivative of Donepezil \| PET probe \| Piperidine \| Sulfonamide \| Sulfur Compound

5DYY-5hh	BCHE	Derivative of Donepezil \| Naphthalen \| Piperidine \| Sulfonamide \| Sulfur Compound

6OT-5JZB	Carbon-carbon_bond_hydrolase	Sulfonamide \| Sulfur Compound

6RUA-3a	BCHE	Carboxamide \| Coumarin \| Naphthalen \| Piperidine \| Sulfonamide \| Sulfur Compound

ABD957	ABHD17-depalmitoylase	Piperazine \| Pyrazole \| Sulfonamide \| Sulfur Compound \| Trifluoro

AZ12756122	Thioesterase	Cyanide \| Piperidine \| Sulfonamide \| Sulfur Compound

Bensulide	BCHE	Herbicide \| Not A/B H target \| Organophosphate \| Sulfonamide \| Sulfur Compound

CHEMBL1624646	ACHE	Sulfonamide \| Sulfur Compound

CHEMBL3087804	ACHE	Sulfonamide \| Sulfur Compound

CHEMBL3087806	ACHE	Sulfonamide \| Sulfur Compound

CHEMBL3087807	ACHE	Sulfonamide \| Sulfur Compound

CHEMBL3087808	ACHE	Sulfonamide \| Sulfur Compound

CHEMBL3087809	ACHE	Sulfonamide \| Sulfur Compound \| Trifluoro

CHEMBL3087813	ACHE	Sulfonamide \| Sulfonyl \| Sulfur Compound

CHEMBL3087814	ACHE	Sulfonamide \| Sulfur Compound

CHEMBL3087815	ACHE	Sulfonamide \| Sulfur Compound \| Trifluoro

CHEMBL3585776	ACHE	Carbamate \| Sulfonamide \| Sulfur Compound

CHEMBL4076637	PAF-Acetylhydrolase	Sulfonamide \| Sulfur Compound

CHEMBL4451596	Epoxide_hydrolase	Pyridine \| Sulfonamide \| Trifluoro

CID155803778	ABHD17-depalmitoylase \| LYsophospholipase_carboxylesterase	Piperazine \| Pyrazole \| Sulfonamide \| Sulfur Compound

CID155803782	ABHD17-depalmitoylase \| LYsophospholipase_carboxylesterase	Morpholine \| Piperazine \| Pyrazole \| Sulfonamide \| Sulfur Compound \| Trifluoro

CID155803786	ABHD17-depalmitoylase	Morpholine \| Piperazine \| Pyrazole \| Sulfonamide \| Sulfur Compound \| Trifluoro

CID155803792	ABHD17-depalmitoylase \| LYsophospholipase_carboxylesterase	Morpholine \| Piperazine \| Pyrazole \| Sulfonamide \| Sulfur Compound \| Trifluoro

Diclofenac-derivative-39	ACHE	5-Lipoxygenase inhibitor \| Monoamine-oxidase-inhibitor \| Multitarget \| Pyrazole \| Sulfonamide \| Sulfur Compound

Famphur	ACHE	Insecticide \| Organophosphate \| Sulfonamide \| Sulfur Compound

GSK-264220A	Lipoprotein_Lipase	Sulfonamide \| Sulfur Compound \| Urea derivative

GTPL9797	PAF-Acetylhydrolase	Piperidine \| Sulfonamide \| Sulfur Compound \| Trifluoro

Indolesufonamide1	DPP4N_Peptidase_S9	Indole \| Sulfonamide \| Sulfur Compound

J8-A34	ACHE	Derivative of Donepezil \| Piperidine \| Sulfonamide \| Sulfur Compound

JUB	BCHE	Benzoxadiazole \| NBD-nitro-benzoxadiazol-fluorescent \| Naphthalen \| Piperazine \| Piperidine \| Sulfonamide \| Sulfur Compound

P-Toluenesulfonamide	Carb_B_Chordata	Sulfonamide \| Sulfur Compound

P1-benzoxadiazole-fluorogenic-ligand	Haloalkane_dehalogenase-HLD2	Benzoxadiazole \| Fluorescent Probe \| Sulfonamide \| Sulfur Compound

PTUPB	Epoxide_hydrolase	Multitarget \| Pyrazole \| Sulfonamide \| Sulfur Compound \| Trifluoro \| Urea derivative

SBP-7635	Thioesterase	Sulfonamide \| Sulfur Compound \| Thiazolidine

SBP-7957	Thioesterase	Morpholine \| Sulfonamide \| Sulfur Compound \| Thiazolidine

SR-3133	CGI-58_ABHD5_ABHD4	Benzofuran \| Piperazine \| Sulfonamide \| Sulfur Compound

SR-3134	CGI-58_ABHD5_ABHD4	Benzofuran \| Piperazine \| Sulfonamide \| Sulfur Compound

SR-4559	CGI-58_ABHD5_ABHD4	Benzofuran \| Piperazine \| Sulfonamide \| Sulfur Compound

SZC	Epoxide_hydrolase	Benzimidazole \| Imidazole \| Sulfonamide \| Sulfur Compound \| Trifluoro

Sulfapyridine	Pectinacetylesterase-Notum	Antibiotic \| Fragment inhibitor of Notum \| Not A/B H target \| Pyridine \| Sulfonamide \| Sulfur Compound

Sulfonamide-D1C	DPP4N_Peptidase_S9	Sulfonamide \| Sulfur Compound \| Trifluoro

TUPS	Epoxide_hydrolase	Piperidine \| Sulfonamide \| Sulfur Compound \| Trifluoro \| Urea derivative

Tosyl-L-lysine-chloromethyl-ketone	BCHE \| Carb_B_Bacteria \| S9N_PREPL_Peptidase_S9	Ketone \| Peptide \| Sulfonamide \| Sulfur Compound

ZINC59501712	BCHE	Indole \| Phthalimido \| Sulfonamide \| Sulfur Compound

bis-benzene-sulfonamide	Carb_B_Chordata \| Carboxylesterase	Lipase inhibitor \| Sulfonamide \| Sulfur Compound

dansyl-PEG2-HaloTag	Haloalkane_dehalogenase-HLD2	HaloTag-ligand \| Naphthalen \| Poly-ethylene-glycol \| Polymer \| Sulfonamide \| Sulfur Compound

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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