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Type_inhibitor Report for: Pyrimidine

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. The other diazines are pyrazine (nitrogen atoms at the 1 and 4 positions) and pyridazine (nitrogen atoms at the 1 and 2 positions). In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U) Building block for many inhibitors of enzymes

InhibitorMain targeted enzyme familiesTypeStructure
24DEpoxide_hydrolase Carboxamide | Piperidine | Pyrimidine
3-amino-4-phenyl-pyrrolidine-15BDPP4N_Peptidase_S9 Pyridine | Pyrimidine | Pyrrolidine | Trifluoro
5ALI-Q3BEpoxide_hydrolase Imidazole | Pyrimidine | Urea derivative
5ALU-HD2Epoxide_hydrolase Adamantyl | Carboxamide | Not A/B H target | Pyrimidine
5APDPP4N_Peptidase_S9 Pyrimidine
5LP1-71HPAF-Acetylhydrolase Pyrimidine | Sulfur Compound | Trifluoro
75L-5T4EDPP4N_Peptidase_S9 Piperidine | Purine | Pyrimidine | Quinazoline
AlogliptinDPP4N_Peptidase_S9 Cyanide | Drug | Gliptin | Piperidine | Pyrimidine
AnagliptinDPP4N_Peptidase_S9 Carboxamide | Cyanide | Drug | Gliptin | Pyrazole | Pyrimidine | Pyrrolidine
C-547ACHE Bisquaternary | Pyrimidine | Uracil derivative
CHEMBL1214943DPP4N_Peptidase_S9 Morpholine | Pyrimidine
CHEMBL1215376DPP4N_Peptidase_S9 Carboxamide | Pyrimidine
CHEMBL1910111DPP4N_Peptidase_S9 Pyridine | Pyrimidine | Pyrrolidine
CHEMBL2159182DPP4N_Peptidase_S9 Pyrimidine
CHEMBL3233607-S0G-3WKAEpoxide_hydrolase Piperidine | Pyrimidine
CHEMBL351434PAF-Acetylhydrolase Pyrimidine | Sulfur Compound
CHEMBL3793506PAF-Acetylhydrolase Cyanide | Morpholine | Pyrimidine | Trifluoro
DLIDPP4N_Peptidase_S9 Pyrimidine | Pyrrolidine | Sulfur Compound | Trifluoro
DarapladibPAF-Acetylhydrolase Pyrimidine | Sulfur Compound | Trifluoro
DiazinonACHE Insecticide | Organophosphate | Organothiophosphate | Pyrimidine | Sulfur Compound
Diazinon-oxonACHE Insecticide | Organophosphate | Pyrimidine
Fragment-067Pectinacetylesterase-Notum Fragment inhibitor of Notum | Pyrazole | Pyrimidine
Fragment-823 Fragment inhibitor of Notum | Pyrimidine
GemigliptinDPP4N_Peptidase_S9 Drug | Gliptin | Piperidine | Pyrimidine | Trifluoro
GosogliptinDPP4N_Peptidase_S9 Drug | Gliptin | Piperidine | Pyrimidine
Indol-thioxotetrahydropyrimidine-Cpd5ACHE Indole | Pyrimidine | Sulfur Compound
Indol-thioxotetrahydropyrimidine-Cpd7BCHE Indole | Pyrimidine | Sulfur Compound
LP-914822Pectinacetylesterase-Notum Pyrimidine | Sulfur Compound
LP-922056Pectinacetylesterase-Notum Cyclopropyl | Pyrimidine | Sulfur Compound
M9NPectinacetylesterase-Notum Pyrimidine | Sulfur Compound
Piperidine-constrained-phenethylamine-42DPP4N_Peptidase_S9 Piperidine | Pyrimidine | Sulfur Compound | Trifluoro
PirimicarbACHE Carbamate | Insecticide | Pyrimidine
Pirimiphos-methylACHE Insecticide | Organophosphate | Pyrimidine | Sulfur Compound
Pyrimidinone-inhibitor1DPP4N_Peptidase_S9 Piperazine | Pyrimidine
Pyrimidinone-inhibitor3DPP4N_Peptidase_S9 Cyanide | Pyrimidine
Tacrine-dihydropyrimidine-4eACHE Calcium Channel Antagonist | Derivative of Tacrine | Multitarget | Pyrimidine | Quinoline | Sulfur Compound
TebupirimfosACHE | BCHE Insecticide | Organophosphate | Pyrimidine | Sulfur Compound
TrelagliptinDPP4N_Peptidase_S9 Cyanide | Drug | Gliptin | Piperidine | Pyrimidine
Xanthine-inhibitor-4DPP4N_Peptidase_S9 Cyanide | Piperidine | Purine | Pyrimidine
ZYHMonoglyceridelipase_lysophospholip Azetidin | Piperazine | Pyrimidine
ZYH-deriv-FMonoglyceridelipase_lysophospholip Azetidin | Carboxamide | PET probe | Piperazine | Pyrimidine

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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