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Type_inhibitor Report for: HaloTag-ligand

The HaloTag is composed of covalently bound haloalkane dehalogenase and a synthetic ligand of choice. The bacterial enzyme can be fused to various proteins of interest to visualize its subcellular localization.Ssynthetic ligands consist of a reactive chloroalkane linker bound to a functional group such as biotin (can be used as an affinity tag) or a fluorescent dye (Coumarin, Oregon Green, Alexa Fluor 488, diAcFAM, or TMR)

InhibitorMain targeted enzyme familiesTypeStructure
Chloroalkane-Cyanine3-fluorophoreHaloalkane_dehalogenase-HLD2 HaloTag-ligand | Indole
Chloroalkane-carbopyronine-fluorophoreHaloalkane_dehalogenase-HLD2 Fluorescent Probe | HaloTag-ligand
Chloroalkane-tetramethylrhodamine-fluorophoreHaloalkane_dehalogenase-HLD2 Fluorescent Probe | HaloTag-ligand | Rhodamine derivative
HALSTS-1Q9Haloalkane_dehalogenase-HLD2 HaloTag-ligand | Tetrazol
HALSTS1Haloalkane_dehalogenase-HLD2 HaloTag-ligand | Tetrazol
JF635Haloalkane_dehalogenase-HLD2 Azetidin | Benzofuran | Carboxamide | Fluorescent Probe | HaloTag-ligand
JF635iHaloalkane_dehalogenase-HLD2 Fluorescent Probe | HaloTag-ligand
Me-TRaQ-GHaloalkane_dehalogenase-HLD2 HaloTag-ligand
TMR-Hy5Haloalkane_dehalogenase-HLD2 HaloTag-ligand
TMR-S4Haloalkane_dehalogenase-HLD2 HaloTag-ligand
TMR-S5Haloalkane_dehalogenase-HLD2 HaloTag-ligand
TMR-T4Haloalkane_dehalogenase-HLD2 HaloTag-ligand
TMR-T5Haloalkane_dehalogenase-HLD2 HaloTag-ligand
TRaQ-G-ILQHaloalkane_dehalogenase-HLD2 HaloTag-ligand
TRaQ-G-ILUHaloalkane_dehalogenase-HLD2 HaloTag-ligand
TRaQ-G-ctrlHaloalkane_dehalogenase-HLD2 HaloTag-ligand
UL2-8MSHaloalkane_dehalogenase-HLD2 Fluorescent Probe | HaloTag-ligand
VL1-8MHHaloalkane_dehalogenase-HLD2 Fluorescent Probe | HaloTag-ligand | Isoquinoline | Quinoline
dansyl-PEG2-HaloTagHaloalkane_dehalogenase-HLD2 HaloTag-ligand | Naphthalen | Poly-ethylene-glycol | Polymer | Sulfonamide | Sulfur compound
tetramethylrhodamine-HaloTag-ligandHaloalkane_dehalogenase-HLD2 Fluorescent Probe | HaloTag-ligand | Rhodamine derivative

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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