Type_inhibitor Report for: GSK-3 kinase inhibitor

Inhibition of glycogen synthase kinase-3 ameliorates beta-amyloid pathology. Multi targets inhibitors have been developped in order to inhibit both GSK-3 kinase and cholinesterases as well as other pathways

Inhibitor	Main targeted enzyme families	Type

6H12-(R)2	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative

6H13-(R)3	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative

6H14-(S)6	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative \| beta-carboline

ACHE-GSK-3-27g	ACHE	Derivative of Tacrine \| GSK-3 kinase inhibitor \| Multitarget

BIGI-3h	ACHE \| BCHE	Calcium Channel Antagonist \| GSK-3 kinase inhibitor \| Monoamine-oxidase-inhibitor \| Multitarget \| anti-Abeta-aggregation

TDZD8	Pectinacetylesterase-Notum	GSK-3 kinase inhibitor \| Not A/B H target \| Thiadiazol

ZLWH-23	ACHE	Carboxamide \| Cyclopropyl \| GSK-3 kinase inhibitor \| Multitarget \| Piperidine \| beta-carboline

ZTL-11	ACHE	Carboxamide \| Cyclopropyl \| GSK-3 kinase inhibitor \| Multitarget \| Triazol \| beta-carboline

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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