Type Inhibitor

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Type_inhibitor Report for: Derivative of Tacrine

Tacrine (tetra trahydroaminacrine) was the first inhibitor of AChE used in Alzheimer's disease but has many side effects and is dicontinued. Tacrine was used as a building block to find less toxic inhibitors or multi target drugs

Inhibitor	Main targeted enzyme families	Type

(R)-Tacrine(10)-Hupyridone	ACHE	Alkyl linked bis-ligand \| Derivative of Huperzine \| Derivative of Tacrine \| Quinoline

6-chlorotacrine	ACHE	Derivative of Tacrine

6H12-(R)2	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative

6H13-(R)3	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative

6H14-(S)6	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative \| beta-carboline

6o-5-HT3	ACHE \| BCHE	5-HT-receptor-ligand \| Carboxamide \| Derivative of Tacrine \| Multitarget

7-MEOTA-4-pyridinealdoxime	ACHE	Acridine \| Derivative of Tacrine \| Pyridine

7-Methoxytacrine	ACHE	Acridine \| Derivative of Tacrine

7-Nitrotacrine	ACHE	Acridine \| Derivative of Tacrine

9-Amino-6-chloro-2-methoxyacridine	Carb_B_Chordata \| Carboxylesterase	Acridine \| Derivative of Tacrine

ACHE-GSK-3-27g	ACHE	Derivative of Tacrine \| GSK-3 kinase inhibitor \| Multitarget

Aroylacrylic-acid-amide-Tacrine-10	ACHE \| BCHE	Alkyl linked bis-ligand \| Derivative of Tacrine

AzoTHA	ACHE	Acridine \| Derivative of Tacrine \| Photoswitch

Bis3-tacrine	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine

Bis5-tacrine	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine

Bis7-tacrine	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine

Bromophenyl-tacrine6i	ACHE \| BCHE	Derivative of Tacrine

Bucricaine	ACHE	Derivative of Tacrine \| Local anesthetic

C0I-7QHD	BCHE	Acridine \| Alkyl linked bis-ligand \| Carboxamide \| Derivative of Donepezil \| Derivative of Tacrine \| Indole \| Piperidine

C4I-7QHE	BCHE	Acridine \| Alkyl linked bis-ligand \| Carboxamide \| Derivative of Donepezil \| Derivative of Tacrine \| Naphthalen \| Piperidine

CB1R-ACHE-20	ACHE	Cannabinoid-Receptor-ligand \| Carboxamide \| Derivative of Tacrine \| Imidazole \| Multitarget

CI-1002	ACHE	Derivative of Tacrine \| Muscarinic antagonist \| Quinazoline

CMP-DDAO	ACHE	Derivative of Tacrine \| Flu-OP \| Nerve Agent G-series \| Organophosphate \| Surrogate OP

Chlorotacrine-juglone	ACHE	Acridine \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Naphthalen \| anti-Abeta-aggregation

Chlorotacrine-tryptophan-hybrid	ACHE \| BCHE	Derivative of Tacrine \| Multitarget \| anti-Abeta-aggregation

Compound4Tacrine	ACHE	Derivative of Tacrine

Cpd17-Tacrine-5-HT6	ACHE \| BCHE	5-HT-receptor-ligand \| Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Indole \| Multitarget \| Sulfur Compound \| anti-Abeta-aggregation

DTE-bis8-Tacrine	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Photoswitch

E0Z	ACHE	Derivative of Tacrine \| Triazol

E1K	ACHE	Derivative of Tacrine

E1N	ACHE	Derivative of Huperzine \| Derivative of Tacrine

EMP-DDAO	ACHE	Derivative of Tacrine \| Flu-OP \| Nerve Agent V-series \| Organophosphate \| Surrogate OP

FBQ	ACHE	Derivative of Tacrine \| Quinoline \| Sulfur Compound \| Transition state analogue \| Trifluoro

HuprineW	ACHE	Derivative of Huperzine \| Derivative of Tacrine \| Natural_modified \| Quinoline

HuprineX	ACHE	Derivative of Huperzine \| Derivative of Tacrine \| Natural_modified \| Quinoline

IMP-DDAO	ACHE	Derivative of Sarin \| Derivative of Tacrine \| Flu-OP \| Nerve Agent G-series \| Organophosphate \| Surrogate OP

K-1234	ACHE	Derivative of Huperzine \| Derivative of Tacrine

Lipocrine	ACHE	Antioxidant \| Derivative of Tacrine \| Multitarget \| Sulfur Compound

N-ammoniooctyl-tacrine	ACHE	Acridine \| Derivative of Tacrine

N-octyl-tacrine	ACHE	Acridine \| Derivative of Tacrine

NF595	ACHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Sulfur Compound

NIK-247	ACHE \| BCHE	Derivative of Tacrine \| Quinoline

NP61	ACHE \| BCHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Indole

PE154	ACHE \| BCHE	Derivative of Tacrine \| Hydrazide \| Multitarget

PMP-DDAO	ACHE	Derivative of Soman \| Derivative of Tacrine \| Flu-OP \| Nerve Agent G-series \| Organophosphate \| Surrogate OP

Phenothiazine-Tacrine-1dC	ACHE	Acridine \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Phenothiazine \| anti-Abeta-aggregation

Propargyl-Tacrine-15	ACHE \| BCHE	Alkyne \| Derivative of Tacrine \| Monoamine-oxidase-inhibitor \| Multitarget

QTC-4-MeOBnE	ACHE	BACE1-inhibitor \| Derivative of Tacrine \| Multitarget \| Triazol

SCHEMBL1532301		Acridine \| Alkyl linked bis-ligand \| Derivative of Donepezil \| Derivative of Tacrine \| Isoindol

Salicylamide-8-Tacrine	ACHE \| BCHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Salicylic

TADE	ACHE \| BCHE	Derivative of Tacrine

TFAH-tacrine-ferulic-acid-hybrid-10n	BCHE	Acrylate \| Antioxidant \| Derivative of Tacrine \| Hydroxycinnamic-ester \| Multitarget

TPPU-6-Chlorotacrine-12c	ACHE \| Epoxide_hydrolase	Derivative of Tacrine \| Multitarget \| Piperidine \| Trifluoro \| Urea derivative

TZ2PIQA5		Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Quinoline \| Triazol

Tacrine	ACHE	Acridine \| Derivative of Tacrine

Tacrine(8)-4-aminoquinoline	ACHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Quinoline

Tacrine-Benzofuran	ACHE	Acridine \| Alkyl linked bis-ligand \| BACE1-inhibitor \| Benzofuran \| Derivative of Tacrine \| Multitarget

Tacrine-Donepezil-hybrid3	ACHE	Derivative of Donepezil \| Derivative of Tacrine

Tacrine-Melatonin-Feruloyl-5c	BCHE	Acrylate \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Derivative of Tryptamine \| Feruloyl \| Hydroxycinnamic-ester \| Multitarget

Tacrine-Resveratrol-12	ACHE	Antioxidant \| Derivative of Tacrine \| Multitarget

Tacrine-Trolox-7u	ACHE	Antioxidant \| Carboxamide \| Derivative of Tacrine \| Multitarget

Tacrine-dihydropyrimidine-4e	ACHE	Calcium Channel Antagonist \| Derivative of Tacrine \| Multitarget \| Pyrimidine \| Quinoline \| Sulfur Compound

Tacrine-dipicolylamine-13a	ACHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Multitarget \| anti-Abeta-aggregation

Tacrine-methylanacardate-cpd5	BCHE	Alkyl linked bis-ligand \| Benzoate \| Derivative of Tacrine \| Multitarget \| Salicylic

Tacrine-nicotinamide	ACHE	Alkyl linked bis-ligand \| Carboxamide \| Derivative of Nicotine \| Derivative of Tacrine \| Nicotinamide

Tacrine-pentylmethylene-tolylsulfonamide		Alkyl linked bis-ligand \| Derivative of Tacrine

Tacrine-pyridinealdoxime-1	ACHE	Acridine \| Derivative of Tacrine

Tz2	ACHE	Acridine \| Azido \| Derivative of Tacrine

Tz2Pa5-anti1	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Phenanthridinium \| Triazol

Tz2Pa5-syn1	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Phenanthridinium \| Triazol

Tz2Pa6-anti1	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Phenanthridinium \| Triazol

Tz2Pa6-syn1	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Phenanthridinium \| Triazol

ZA	ACHE	Acridine \| Derivative of Tacrine

ZAI	ACHE	Acridine \| Derivative of Tacrine

[11C]N-methyl-tacrine	ACHE	Acridine \| Derivative of Tacrine \| PET probe

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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