Type_inhibitor Report for: Derivative of Donepezil

Donepezil used in treatment of Alzheimer Disease, trademark is Aricept Reversible inhibitor of AChE but not of BChE. Used as a building block of new inhibitors and also multi-target drug candidates

Inhibitor	Main targeted enzyme families	Type

5DYT-5hb	BCHE	Derivative of Donepezil \| Naphthalen \| Piperidine \| Sulfonamide \| Sulfur Compound

5DYW-5hf	BCHE	Derivative of Donepezil \| Naphthalen \| Piperidine \| Sulfonamide \| Sulfur Compound

5DYW-5hf-C11	BCHE	Derivative of Donepezil \| Naphthalen \| PET probe \| Piperidine \| Sulfonamide \| Sulfur Compound

5DYW-5hf-F	BCHE	Derivative of Donepezil \| PET probe \| Piperidine \| Sulfonamide \| Sulfur Compound

5DYY-5hh	BCHE	Derivative of Donepezil \| Naphthalen \| Piperidine \| Sulfonamide \| Sulfur Compound

7QB4-Cpd2	ACHE	Coumarin \| Derivative of Donepezil \| Monoamine-oxidase-inhibitor \| Multitarget

Aricept~Donepezil~E2020	ACHE	Derivative of Donepezil \| Drug \| Inden \| Piperidine

BYYT-25	ACHE \| BCHE \| Cholinesterase	Derivative of Donepezil \| Derivative of Rivastigmine \| Inden

C0I-7QHD	BCHE	Acridine \| Alkyl linked bis-ligand \| Carboxamide \| Derivative of Donepezil \| Derivative of Tacrine \| Indole \| Piperidine

C4I-7QHE	BCHE	Acridine \| Alkyl linked bis-ligand \| Carboxamide \| Derivative of Donepezil \| Derivative of Tacrine \| Naphthalen \| Piperidine

C7653	ACHE	Derivative of Donepezil \| Piperidine

CHEMBL4293015	BCHE	Alkyl linked bis-ligand \| Derivative of Donepezil \| Indole \| Piperidine

Compound19n-quinolinol		Derivative of Donepezil \| Metal ion chelator \| Multitarget \| Quinoline \| Trifluo \| anti-Abeta-aggregation

Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol	ACHE	BACE1-inhibitor \| Carboxamide \| Cyanide \| Derivative of Donepezil \| Multitarget \| Oxadiazol \| Piperidine \| Sulfur Compound \| anti-Abeta-aggregation

DFAH-12	ACHE \| BCHE	Antioxidant \| Derivative of Donepezil \| Hydroxycinnamic-ester \| Multitarget \| Piperidine

DPH6	ACHE \| BCHE	Derivative of Donepezil \| Monoamine-oxidase-inhibitor \| Multitarget \| Quinoline

Donecopride	ACHE	5-HT-receptor-ligand \| Derivative of Donepezil \| Multitarget \| Piperidine

Donepezil-8-Hydroxyquinoline-2b	BCHE	Antioxidant \| Derivative of Donepezil \| Multitarget \| Quinoline

Donepezil-Melatonin-4u		Antioxidant \| Derivative of Donepezil \| Derivative of Tryptamine \| Multitarget

Donepezil-derivative-DZ0	ACHE	Derivative of Donepezil \| Inden \| Piperidine

Donepezil-derivative-DZ7	ACHE	Derivative of Donepezil \| Inden \| Piperidine

Donepezil-idebenone-cpd9	BCHE	Antioxidant \| Derivative of Donepezil \| Multitarget \| anti-Abeta-aggregation

Fluoropezil	ACHE	Antioxidant \| Derivative of Donepezil \| Multitarget \| Sulfur Compound

Icopezil	ACHE	Derivative of Donepezil \| Piperidine

MC1420	ACHE	Carboxamide \| Derivative of Donepezil

Mebbpp		Derivative of Donepezil \| Multitarget \| Piperidine \| Sulfur Compound

SCHEMBL1532301		Acridine \| Alkyl linked bis-ligand \| Derivative of Donepezil \| Derivative of Tacrine \| Isoindol

Selenepezil	ACHE	Derivative of Donepezil \| Organoselenium \| Piperidine \| Thiol-reactive

Sigma1R-ACHE-6a	ACHE	5-HT-receptor-ligand \| Derivative of Donepezil \| Multitarget \| Piperidine \| Sigma1R

Sigma1R-ACHE-6b	ACHE	5-HT-receptor-ligand \| Derivative of Donepezil \| Multitarget \| Piperidine \| Sigma1R

TAK-147	ACHE	Derivative of Donepezil \| Piperidine \| Transition state analogue

Tacrine-Donepezil-hybrid3	ACHE	Derivative of Donepezil \| Derivative of Tacrine

WMY90-5f	ACHE	Derivative of Donepezil \| Monoamine-oxidase-inhibitor \| Multitarget \| Quinoline

ZINC11709541	ACHE	Derivative of Donepezil \| Trifluoro

ZINC11996936	ACHE	Derivative of Donepezil \| Trifluoro

ZINC22029744	ACHE \| BCHE	BACE1-inhibitor \| Derivative of Donepezil \| Multitarget \| Oxadiazol \| Piperazine \| Sulfur Compound

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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