Type Inhibitor

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Type_inhibitor Report for: Multitarget

Multitarget directed ligand (MTDL). In case of Alzheimer disease enzymes or pathways targeted include: Inhibition of AChE and or BCHE, Inhibition of glycogen synthase kinase-3 (GSK-3 kinase), BACE1-inhibitor (beta-secretase-1), antioxidant, Cannabinoid-Receptor-ligand, Sigma1R, Histamine-Receptor3-H3-Antagonist, H1-antihistamine, 5-HT-receptor-agonist, NMDA-ligand, Ca2+ channels block, Abeta aggregation, Metal ion chelator. Inhibition of multiple enzymes of the arachidonic acid cascade leads to synergistic anti-inflammatory effects. The targets include in these cases soluble epoxide hydrolase (sEH), 5-lipoxygenase (5-LOX), LTA4-hydrolase-inhibitor, dual sEH/FAAH

Inhibitor	Main targeted enzyme families	Type

11a-quinoxaline	ACHE \| BCHE \| Cholinesterase	Histamine-Receptor3-H3-Antagonist \| Multitarget \| Quinoxaline

15d-PGJ2	Epoxide_hydrolase	Multitarget \| PPARgamma ligand \| Prostaglandin

18-E100	ACHE \| BCHE \| Cholinesterase	Azepane \| Histamine-Receptor3-H3-Antagonist \| Multitarget \| Piperidine

3,5-dihydroxybenzamido-huprine-hybrid-11	ACHE \| BCHE	Alkyl linked bis-ligand \| BACE1-inhibitor \| Derivative of Huperzine \| Multitarget

3-butyl-6-benzyloxyphthalide-Mannich-base-7d	ACHE	Benzofuran \| Monoamine-oxidase-inhibitor \| Multitarget \| Piperidine

40V	BCHE	Carboxamide \| Inden \| Metal ion chelator \| Multitarget \| Piperidine \| Quinoline

4c2-AChE-IN-24	ACHE	Multitarget \| Piperidine \| Sulfur Compound

6F7Q-cpd11	BCHE	Antioxidant \| Carboxamide \| Inden \| Metal ion chelator \| Multitarget \| Piperidine \| Quinoline

6H12-(R)2	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative

6H13-(R)3	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative

6H14-(S)6	ACHE	Derivative of Tacrine \| Derivative of Valmerin \| GSK-3 kinase inhibitor \| Isoindole \| Multitarget \| Triazol \| Urea derivative \| beta-carboline

6SAM-cpd13	BCHE	Carbamate \| Inden \| Monoamine-oxidase-inhibitor \| Multitarget \| Piperidine

6ZWE-Cpd3	ACHE \| BCHE	Antioxidant \| Benzodioxo \| Multitarget

6o-5-HT3	ACHE \| BCHE	5-HT-receptor-ligand \| Carboxamide \| Derivative of Tacrine \| Multitarget

7QAK-Cpd1	ACHE	Coumarin \| Monoamine-oxidase-inhibitor \| Multitarget

7QB4-Cpd2	ACHE	Coumarin \| Derivative of Donepezil \| Monoamine-oxidase-inhibitor \| Multitarget

8U2-7AIX7AY-compound5i	ACHE \| BCHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8U5-7AIW-compound5g	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8UE-7AIV-compound5f	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8UH-7AIS-compound5b	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8UK-7AIT-compound5c	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8UQ-7AIU-compound5d	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

ACHE-GSK-3-27g	ACHE	Derivative of Tacrine \| GSK-3 kinase inhibitor \| Multitarget

AI0-7QBQ	BCHE	Monoamine-oxidase-inhibitor \| Multitarget \| Quinoline

AI6-7QBR	BCHE	Monoamine-oxidase-inhibitor \| Multitarget \| Piperazine \| Quinoline \| tert-Butyl

AM6701	ABHD6-Lip \| Monoglyceridelipase_lysophospholip	Biphenyl \| Cannabinoid-Receptor-ligand \| Carboxamide \| FAAH inhibitor \| Multitarget \| Tetrazol \| Urea derivative

ARN14140	ACHE	Derivative of Galanthamine \| Multitarget \| NMDA-ligand

ASS234	ACHE	Monoamine-oxidase-inhibitor \| Multitarget \| Piperidine

Amantadine-M30D-hybrid5e	BCHE	Adamantyl \| Carbamate \| Monoamine-oxidase-inhibitor \| Multitarget

Ass-IN-10	BCHE	BACE1-inhibitor \| Multitarget \| anti-Abeta-aggregation \| anti-tau-aggregation \| tert-Butyl

BIA-10-2474	ABHD6-Lip \| Carb_B_Chordata	Carboxamide \| FAAH inhibitor \| Imidazole \| Multitarget \| Pyridine

BIGI-3h	ACHE \| BCHE	Calcium Channel Antagonist \| GSK-3 kinase inhibitor \| Monoamine-oxidase-inhibitor \| Multitarget \| anti-Abeta-aggregation

CB1R-ACHE-20	ACHE	Cannabinoid-Receptor-ligand \| Carboxamide \| Derivative of Tacrine \| Imidazole \| Multitarget

CB2R-BCHE-20a	BCHE	Cannabinoid-Receptor-ligand \| Carboxamide \| Imidazole \| Multitarget \| Piperidine

CB2R-BCHE-x	BCHE	Cannabinoid-Receptor-ligand \| Carboxamide \| Imidazole \| Multitarget \| Piperidine

CHEMBL440526	ACHE \| BCHE	Carbamate \| Coumarin \| Multitarget

CHEMBL4442990	BCHE	Benzofuran \| Cannabinoid-Receptor-ligand \| Multitarget

Chlorotacrine-juglone	ACHE	Acridine \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Naphthalen \| anti-Abeta-aggregation

Chlorotacrine-tryptophan-hybrid	ACHE \| BCHE	Derivative of Tacrine \| Multitarget \| anti-Abeta-aggregation

Chlorpromazine	ACHE \| BCHE	Drug \| Multitarget \| Not A/B H target \| Phenothiazine \| Sulfur Compound

Compound19n-quinolinol	ACHE	Derivative of Donepezil \| Metal ion chelator \| Multitarget \| Quinoline \| Trifluo \| anti-Abeta-aggregation

Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol	ACHE	BACE1-inhibitor \| Carboxamide \| Cyanide \| Derivative of Donepezil \| Multitarget \| Oxadiazol \| Piperidine \| Sulfur Compound \| anti-Abeta-aggregation

Contilisant	ACHE \| BCHE	Histamine-Receptor3-H3-Antagonist \| Monoamine-oxidase-inhibitor \| Multitarget \| Piperidine

Cpd14-BChEin-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Indole \| Multitarget \| Sulfur Compound

Cpd17-Tacrine-5-HT6	ACHE \| BCHE	5-HT-receptor-ligand \| Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Indole \| Multitarget \| Sulfur Compound \| anti-Abeta-aggregation

Cpd27-BChEin-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Indole \| Multitarget \| Sulfur Compound

Cpd35-Rivastigmine-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Carbamate \| Derivative of Rivastigmine \| Indole \| Multitarget \| Sulfur Compound \| anti-Abeta-aggregation

Cpd37-Fluoroindol-carbamate	Monoglyceridelipase_lysophospholip	Carbamate \| FAAH inhibitor \| Indole \| Multitarget

Cpd54-BChEin-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Indole \| Multitarget \| Sulfur Compound \| tert-Butyl \| tert-Butyloxycarbonyl

Cpd70-BChEin-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Indole \| Multitarget

DFAH-12	ACHE \| BCHE	Antioxidant \| Derivative of Donepezil \| Hydroxycinnamic-ester \| Multitarget \| Piperidine

DPH6	ACHE \| BCHE	Derivative of Donepezil \| Monoamine-oxidase-inhibitor \| Multitarget \| Quinoline

Di-tert-butyl-4-Amino-2,3-cycloheptaquinoline-8c	BCHE	Antioxidant \| Multitarget \| Quinoline \| tert-Butyl

Diclofenac-derivative-39	ACHE	5-Lipoxygenase inhibitor \| Monoamine-oxidase-inhibitor \| Multitarget \| Pyrazole \| Sulfonamide \| Sulfur Compound

Dihydroindole-thiourea-73	Epoxide_hydrolase	5-Lipoxygenase inhibitor \| Indole \| Multitarget \| Sulfur Compound \| Urea derivative

Dihydroquinazoline-carboxamide-34	Epoxide_hydrolase	5-Lipoxygenase inhibitor \| Carboxamide \| Multitarget \| Quinazoline \| Sulfur Compound

Dimethylhydroxycarbaphen	BCHE	Carbamate \| Multitarget \| Muscarinic antagonist \| Not A/B H target \| Pro-Drug \| Propionate

Donecopride	ACHE	5-HT-receptor-ligand \| Derivative of Donepezil \| Multitarget \| Piperidine

Donepezil-8-Hydroxyquinoline-2b	BCHE	Antioxidant \| Derivative of Donepezil \| Multitarget \| Quinoline

Donepezil-Melatonin-4u	ACHE	Antioxidant \| Derivative of Donepezil \| Derivative of Tryptamine \| Multitarget

Donepezil-idebenone-cpd9	BCHE	Antioxidant \| Derivative of Donepezil \| Multitarget \| anti-Abeta-aggregation

Evodiamine	BCHE	Derivative of Evodiamine \| Multitarget \| Natural \| Not A/B H target \| beta-carboline

FL217	Epoxide_hydrolase	Cyclopropyl \| Multitarget \| PPARgamma ligand

Fluoropezil	ACHE	Antioxidant \| Derivative of Donepezil \| Multitarget \| Sulfur Compound

IDFP	Monoglyceridelipase_lysophospholip \| PC-sterol_acyltransferase	FAAH inhibitor \| Multitarget \| Organophosphate

IDFPen	PC-sterol_acyltransferase	FAAH inhibitor \| Multitarget \| Organophosphate

Idalopirdine-rivastigmine	BCHE	5-HT-receptor-ligand \| Carbamate \| Derivative of Rivastigmine \| Drug \| Multitarget \| Pro-Drug

JM-20		2-nitrophenyl \| Benzodiazepin \| Multitarget \| Not A/B H target \| Pyridine

JS0-7ZPB	BCHE	Monoamine-oxidase-inhibitor \| Multitarget \| Piperazine \| Quinoline

JZL184	ABHD6-Lip \| Carb_B_Chordata \| Monoglyceridelipase_lysophospholip	Benzodioxo \| FAAH inhibitor \| Multitarget \| Piperidine \| pNP

JZL195	ABHD6-Lip \| Carb_B_Chordata \| Monoglyceridelipase_lysophospholip	FAAH inhibitor \| Multitarget \| Phenoxyphenyl \| Piperazine \| pNP

LY2183240	ABHD6-Lip \| Arylacetamide_deacetylase \| Monoglyceridelipase_lysophospholip	Biphenyl \| Cannabinoid-Receptor-ligand \| Carboxamide \| FAAH inhibitor \| Multitarget \| Tetrazol \| Urea derivative

Ladostigil	ACHE \| BCHE	Carbamate \| Drug \| Inden \| Monoamine-oxidase-inhibitor \| Multitarget

Lipocrine	ACHE	Antioxidant \| Derivative of Tacrine \| Multitarget \| Sulfur Compound

M30D	ACHE	Carbamate \| Monoamine-oxidase-inhibitor \| Multitarget \| Quinoline

MT-031	ACHE \| BCHE	Carbamate \| Monoamine-oxidase-inhibitor \| Multitarget

MTDL-cpd36-diphenylacetamide	BCHE	BACE1-inhibitor \| Diphenylacetamide \| GABA-transporter-inhibitor \| Multitarget \| anti-Abeta-aggregation \| tert-Butyl

MTDL-cpd51-diphenylacetamide	BCHE	BACE1-inhibitor \| Diphenylacetamide \| GABA-transporter-inhibitor \| Multitarget \| anti-Abeta-aggregation

Mebbpp	ACHE	Derivative of Donepezil \| Multitarget \| Piperidine \| Sulfur Compound

Melatonin-alkylbenzylamine-Cpd5	'BCHE"	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tryptamine \| Multitarget

Memoquin	ACHE	Antioxidant \| BACE1-inhibitor \| Multitarget

Methyl-arachidonyl-fluorophosphonate	CGI-58_ABHD5_ABHD4 \| Monoglyceridelipase_lysophospholip \| PC-sterol_acyltransferase	Cannabinoid-Receptor-ligand \| FAAH inhibitor \| Multitarget \| Organophosphate

Methylene-blue	ACHE \| BCHE	Drug \| Dye \| Multitarget \| Phenothiazine \| Sulfur Compound \| anti-tau-aggregation

Methylene-blue-carboline-2	ACHE \| BCHE \| Cholinesterase	Drug \| Dye \| Multitarget \| Phenothiazine \| Sulfur Compound \| beta-carboline

NMDA-BCHE-C-2h	BCHE	Carbazol \| Multitarget \| NMDA-ligand

OWW-6YL4	Epoxide_hydrolase	5-Lipoxygenase inhibitor \| Multitarget \| Trifluoro

PE154	ACHE \| BCHE	Derivative of Tacrine \| Hydrazide \| Multitarget

PGN33	BCHE	Cannabinoid-Receptor-ligand \| Multitarget

PTUPB	Epoxide_hydrolase	Multitarget \| Pyrazole \| Sulfonamide \| Sulfur Compound \| Trifluoro \| Urea derivative

Phenothiazine	ACHE	Drug \| Multitarget \| Not A/B H target \| Phenothiazine \| Sulfur Compound

Phenothiazine-Tacrine-1dC	ACHE	Acridine \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Phenothiazine \| anti-Abeta-aggregation

Propargyl-Tacrine-15	ACHE \| BCHE	Alkyne \| Derivative of Tacrine \| Monoamine-oxidase-inhibitor \| Multitarget

Pyridophen-10	ACHE	Carbamate \| Multitarget \| Muscarinic antagonist \| Not A/B H target \| PET probe \| Pro-Drug \| Propionate

QTC-4-MeOBnE	ACHE	BACE1-inhibitor \| Derivative of Tacrine \| Multitarget \| Triazol

Quinone-polyamine-NSAID-4	BCHE	5-Lipoxygenase inhibitor \| Multitarget

RS67333	ACHE	5-HT-receptor-ligand \| Multitarget \| Piperidine

SCHEMBL19358888	Epoxide_hydrolase	Benzoate \| FAAH inhibitor \| Multitarget \| Urea derivative

SPB01403	Monoglyceridelipase_lysophospholip	Carbamate \| FAAH inhibitor \| Multitarget \| Sulfur Compound

Salicylamide-8-Tacrine	ACHE \| BCHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Salicylic

Sigma1R-ACHE-6a	ACHE	5-HT-receptor-ligand \| Derivative of Donepezil \| Multitarget \| Piperidine \| Sigma1R

Sigma1R-ACHE-6b	ACHE	5-HT-receptor-ligand \| Derivative of Donepezil \| Multitarget \| Piperidine \| Sigma1R

TFAH-tacrine-ferulic-acid-hybrid-10n	BCHE	Acrylate \| Antioxidant \| Derivative of Tacrine \| Hydroxycinnamic-ester \| Multitarget

TK90	Epoxide_hydrolase	Butyrate \| Carboxamide \| Multitarget \| PPARgamma ligand \| Trifluoro

TPPU-6-Chlorotacrine-12c	ACHE \| Epoxide_hydrolase	Derivative of Tacrine \| Multitarget \| Piperidine \| Trifluoro \| Urea derivative

Tacrine-Benzofuran	ACHE	Acridine \| Alkyl linked bis-ligand \| BACE1-inhibitor \| Benzofuran \| Derivative of Tacrine \| Multitarget

Tacrine-Melatonin-Feruloyl-5c	BCHE	Acrylate \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Derivative of Tryptamine \| Feruloyl \| Hydroxycinnamic-ester \| Multitarget

Tacrine-Resveratrol-12	ACHE	Antioxidant \| Derivative of Tacrine \| Multitarget

Tacrine-Trolox-7u	ACHE	Antioxidant \| Carboxamide \| Derivative of Tacrine \| Multitarget

Tacrine-dihydropyrimidine-4e	ACHE	Calcium Channel Antagonist \| Derivative of Tacrine \| Multitarget \| Pyrimidine \| Quinoline \| Sulfur Compound

Tacrine-dipicolylamine-13a	ACHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Multitarget \| anti-Abeta-aggregation

Tacrine-methylanacardate-cpd5	BCHE	Alkyl linked bis-ligand \| Benzoate \| Derivative of Tacrine \| Multitarget \| Salicylic

URB597	Monoglyceridelipase_lysophospholip	Biphenyl \| Carbamate \| FAAH inhibitor \| Multitarget

UW-MD-71	ACHE \| BCHE \| Cholinesterase	Histamine-Receptor3-H3-Antagonist \| Multitarget \| Quinazoline

WMY90-5f	ACHE	Derivative of Donepezil \| Monoamine-oxidase-inhibitor \| Multitarget \| Quinoline

ZINC22029744	ACHE \| BCHE	BACE1-inhibitor \| Derivative of Donepezil \| Multitarget \| Oxadiazol \| Piperazine \| Sulfur Compound

ZLWH-23	ACHE	Carboxamide \| Cyclopropyl \| GSK-3 kinase inhibitor \| Multitarget \| Piperidine \| beta-carboline

ZTL-11	ACHE	Carboxamide \| Cyclopropyl \| GSK-3 kinase inhibitor \| Multitarget \| Triazol \| beta-carboline

sEH-LTA4H-14	Epoxide_hydrolase	LTA4-hydrolase-inhibitor \| Multitarget \| Sulfur Compound \| Urea derivative

t-AUCMB	Epoxide_hydrolase	Adamantyl \| Multitarget \| Urea derivative

t-MTUCB	Epoxide_hydrolase	Multitarget \| Urea derivative

t-MTUCB-NH	Epoxide_hydrolase	Multitarget \| Urea derivative

t-TUCB	Epoxide_hydrolase	FAAH inhibitor \| Multitarget \| Urea derivative

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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