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Type_inhibitor Report for: Benzyloxycarbonyl

Carboxybenzyl or benzyloxycarbonyl or Cbz or Z (in honor of discoverer Leonidas Zervas) is an amine protecting group in organic chemistry. The protected amine can be deprotected by catalytic hydrogenation or treatment with HBr, yielding a terminal carbamic acid that then readily decarboxylates to yield the free amine. Commonly used for oligopeptide synthesis introduced by Max Bergmann in 1932. Building block for some inhibitors of enzymes

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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