Type Inhibitor

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Type_inhibitor Report for: Alkyl linked bis-ligand

Multitarget compound inhibitors of cholinesterase often bear an alkyl linker that span the active site gorge from the catalytic anionic site to the peripheral anionic site.

Inhibitor	Main targeted enzyme families	Type

(R)-Tacrine(10)-Hupyridone	ACHE	Alkyl linked bis-ligand \| Derivative of Huperzine \| Derivative of Tacrine \| Quinoline

(S,S)-(-)-bis(10)-hupyridone	ACHE	Alkyl linked bis-ligand \| Derivative of Huperzine \| Quinoline

(S,S)-(-)-bis(12)-hupyridone	ACHE	Alkyl linked bis-ligand \| Derivative of Huperzine \| Quinoline

3,5-dihydroxybenzamido-huprine-hybrid-11	ACHE \| BCHE	Alkyl linked bis-ligand \| BACE1-inhibitor \| Derivative of Huperzine \| Multitarget

8U2-7AIX7AY-compound5i	ACHE \| BCHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8U5-7AIW-compound5g	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8UE-7AIV-compound5f	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8UH-7AIS-compound5b	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8UK-7AIT-compound5c	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

8UQ-7AIU-compound5d	ACHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Capsaicin \| Derivative of Huperzine \| Multitarget \| Quinoline

Aroylacrylic-acid-amide-Tacrine-10	ACHE \| BCHE	Alkyl linked bis-ligand \| Derivative of Tacrine

Bis-galanthamine	ACHE	Alkaloid \| Alkyl linked bis-ligand \| Derivative of Galanthamine

Bis3-tacrine	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine

Bis5-tacrine	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine

Bis7-tacrine	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine

Bivalent-4-Aminopyridine-12i	ACHE	Alkyl linked bis-ligand \| Pyridine

C0I-7QHD	BCHE	Acridine \| Alkyl linked bis-ligand \| Carboxamide \| Derivative of Donepezil \| Derivative of Tacrine \| Indole \| Piperidine

C4I-7QHE	BCHE	Acridine \| Alkyl linked bis-ligand \| Carboxamide \| Derivative of Donepezil \| Derivative of Tacrine \| Naphthalen \| Piperidine

CHEMBL4293015	BCHE	Alkyl linked bis-ligand \| Derivative of Donepezil \| Indole \| Piperidine

Chlorotacrine-juglone	ACHE	Acridine \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Naphthalen \| anti-Abeta-aggregation

Cpd14-BChEin-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Indole \| Multitarget \| Sulfur Compound

Cpd17-Tacrine-5-HT6	ACHE \| BCHE	5-HT-receptor-ligand \| Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Indole \| Multitarget \| Sulfur Compound \| anti-Abeta-aggregation

Cpd27-BChEin-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Indole \| Multitarget \| Sulfur Compound

Cpd35-Rivastigmine-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Carbamate \| Derivative of Rivastigmine \| Indole \| Multitarget \| Sulfur Compound \| anti-Abeta-aggregation

Cpd54-BChEin-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Indole \| Multitarget \| Sulfur Compound \| tert-Butyl \| tert-Butyloxycarbonyl

Cpd70-BChEin-5-HT6	BCHE	5-HT-receptor-ligand \| Alkyl linked bis-ligand \| Indole \| Multitarget

DTE-bis8-Tacrine	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Photoswitch

Melatonin-alkylbenzylamine-Cpd5	'BCHE"	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tryptamine \| Multitarget

Methoctramine		Alkyl linked bis-ligand \| Muscarinic antagonist \| Not A/B H target

N-piperidinopropylgalanthamine	ACHE	Alkaloid \| Alkyl linked bis-ligand \| Derivative of Galanthamine \| Natural_modified \| Piperidine

N-saccharinohexylgalanthamine	ACHE	Alkaloid \| Alkyl linked bis-ligand \| Derivative of Galanthamine \| Natural_modified \| Sulfur Compound

NF595	ACHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Sulfur Compound

NP61	ACHE \| BCHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Indole

Phenothiazine-Tacrine-1dC	ACHE	Acridine \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Phenothiazine \| anti-Abeta-aggregation

Phthalimido-Galanthaminium-4d	ACHE	Alkaloid \| Alkyl linked bis-ligand \| Derivative of Galanthamine \| Isoindole \| Natural_modified \| Phthalimido

Phthalimido-Galanthaminium-8d	ACHE	Alkaloid \| Alkyl linked bis-ligand \| Derivative of Galanthamine \| Isoindole \| Natural_modified \| Phthalimido

SCHEMBL1532301	'ACHE"	Acridine \| Alkyl linked bis-ligand \| Derivative of Donepezil \| Derivative of Tacrine \| Isoindol

Salicylamide-8-Tacrine	ACHE \| BCHE	Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Multitarget \| Salicylic

TZ2PIQA5	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Quinoline \| Triazol

Tacrine(8)-4-aminoquinoline	ACHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Quinoline

Tacrine-Benzofuran	ACHE	Acridine \| Alkyl linked bis-ligand \| BACE1-inhibitor \| Benzofuran \| Derivative of Tacrine \| Multitarget

Tacrine-Melatonin-Feruloyl-5c	BCHE	Acrylate \| Alkyl linked bis-ligand \| Antioxidant \| Derivative of Tacrine \| Derivative of Tryptamine \| Feruloyl \| Hydroxycinnamic-ester \| Multitarget

Tacrine-dipicolylamine-13a	ACHE	Alkyl linked bis-ligand \| Derivative of Tacrine \| Multitarget \| anti-Abeta-aggregation

Tacrine-methylanacardate-cpd5	BCHE	Alkyl linked bis-ligand \| Benzoate \| Derivative of Tacrine \| Multitarget \| Salicylic

Tacrine-nicotinamide	ACHE	Alkyl linked bis-ligand \| Carboxamide \| Derivative of Nicotine \| Derivative of Tacrine \| Nicotinamide

Tacrine-pentylmethylene-tolylsulfonamide	ACHE \| BCHE	Alkyl linked bis-ligand \| Derivative of Tacrine

Tz2Pa5-anti1	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Phenanthridinium \| Triazol

Tz2Pa5-syn1	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Phenanthridinium \| Triazol

Tz2Pa6-anti1	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Phenanthridinium \| Triazol

Tz2Pa6-syn1	ACHE	Acridine \| Alkyl linked bis-ligand \| Derivative of Tacrine \| Phenanthridinium \| Triazol

bis9-(-)-nor-meptazinol	ACHE	Alkyl linked bis-ligand \| Azepane

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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