Gene_Locus Report

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Gene_locus Report for: mouse-hslip

Name Class
mouse-hslipNameMus musculus mRNA for hormone sensitive lipase
SpeciesMus musculus
Organismmouse
Gene_nameLIPE
BlockH
FamilyHormone-sensitive_lipase_like
Database (9)
Paper (30)
CommentQ9CTW2 Kawai differs only 1aa from P54310
(from Uniprot) Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters. Shows a preferential hydrolysis of DAGs over TAGs and MAGs and of the fatty acid (FA) esters at the sn-1 and sn-2 positions of the glycerol backbone in TAGs (By similarity). Preferentially hydrolyzes FA esters at the sn-3 position of the glycerol backbone in DAGs. Catalyzes the hydrolysis of 2-arachidonoylglycerol, an endocannabinoid and of 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Sequencemouse-hslip
Typecdna
Proteinmouse-hslip
Peptidemouse-hslip
Other_sequenceMus musculus gene for hormone sensitive lipase exon 2-3
Mouse gene for hormone sensitive lipase, promoter region
InhibitorABP-C6
NBD-TG
NBD-HE-HP
Tree_nodeHormone-sensitive_lipase_like225926

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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