Gene_Locus Report

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Gene_locus Report for: mouse-ABHD6

Name Class
mouse-ABHD6NameMus musculus (Mouse) Monoacylglycerol lipase ABHD6
SpeciesMus musculus
Organismmouse
Gene_name0610041D24RIK
ABHD6
BlockX
FamilyABHD6-Lip
Database (6)
Paper (18)
CommentMonoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzympe hydrolyzing 26AG.(belong to Monoglyceridelipase_lysophospholip family) ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification of Arpigny and Jaeger 1999. Alpha/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.
Proteinmouse-ABHD6
Peptidemouse-ABHD6
SubstrateBis(monoacylglycerol)phosphate
Tree_nodeABHD6-Lip22538
Epoxide-hydrolase_like189389

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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