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Gene_locus Report for: human-PRCP

Name Class
human-PRCPName Homo sapiens (Human) Lysosomal Pro-X carboxypeptidase C prolylcarboxypeptidase , Angiotensinase C, Proline carboxypeptidase (EC3.4.16.2)
SpeciesHomo sapiens
Organismman
Gene_namePRCP
PCP
BlockX
FamilyProlylcarboxypeptidase
Database (14)
Paper (28)
CommentCleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. PRCP was originally discovered as an angiotensinase and has since been implicated in vasodilatory, proinflammatory, and metabolic pathways. For example, angiotensin II, III and prekallikrein are all inactivated by PRCP, implicating a role for the enzyme in hypertension, tissue proliferation and smooth muscle growth. PRCP is also reported to inactivate -melanocyte-stimulating hormone, a neuropeptide that plays a role in regulating appetite
Belongs to peptidase family s28
Sequencehuman-PRCP
Proteinhuman-PRCP
Peptidehuman-PRCP
Structure3N2Z
InhibitorCHEMBL1938516
CHEMBL1684295
UCI-80224067
CHEMBL3086040
Fastaseqhuman-PRCP
Tree_nodeProlylcarboxypeptidase294440
Structure299847
OldTremblA8MU24
B3KRK5

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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