Gene_Locus Report

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Gene_locus Report for: human-NLGN4X

Name Class
human-NLGN4XName Homo sapiens (Human) Neuroligin-4, X-linked (HNLX) Neuroligin4 KIAA0951
SpeciesHomo sapiens
Organismman
Gene_name (5)
BlockC
FamilyNeuroligin
DiseaseNeuroligin 4 Autism AUTSX2 Asperger syndrome ASPGX2
Allelic_variant (6)
Database (15)
Paper (29)
CommentNeuronal cell surface protein involved in cell-cell-interactions. Homodimer. Interacts with NRXN1 in a calcium-dependent manner. Interacts through its C-terminus with DLG4/PSD-95 third PDZ domain. In fact Neuroligin4 is neuroligin X on chromosome X a new entry neuroligin 4Y neuroligin Y is created human-neurxx LOC59203 mRNA in fact identical to 4neur is suppressed
Neuroligin4 mutated in AUTISM, X-LINKED see Jamain et al, Laumonnier et al, Yan et al. see mutation
Sequencehuman-NLGN4X
Proteinhuman-NLGN4X
Peptidehuman-NLGN4X
Mutation (8)
Structure2WQZ
2XB6
3BE8
Fastaseqhuman-NLGN4X
Tree_nodeNeuroligin259481
Non-catalytic_C261461
Structure296541

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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