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Gene_locus Report for: human-DAGLA

Name Class
human-DAGLANameHomo sapiens (Human) DAGLA Sn1-specific diacylglycerol lipase alpha DGL-alpha, neural stem cell-derived dendrite regulator KIAA0659
SpeciesHomo sapiens
Organismman
Gene_nameDagla
C11orf11
Nsddr
KIAA0659
BlockL
FamilyLipase_3
DiseaseNeuro-ocular DAGLA-related syndrome
Database (13)
Paper (26)
CommentDAGLA is a diacylglycerol (DAG) lipase (EC 3.1.1.34) that catalyzes the hydrolysis of DAG to 2-arachidonoyl-glycerol, the most abundant endocannabinoid in tissues. The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission. Only central part Pfam A Lipase_3 394 534. Autoantibodies to DAGLA were detected in the sera of 17 patients with cerebellitis, epilepsy and hippocampal sclerosis, or brain stem encephalitis. A duplication of 20 genes, including DAGLA, resulted in adult onset spinocerebellar ataxia (Knight et al. 2004 2008)
Proteinhuman-DAGLA
Peptidehuman-DAGLA
Mutation (7)
Inhibitor (12)
Substrate1-Oleoyl-2-arachidonoyl-sn-glycerol
1-Stearoyl-2-arachidonoylglycerol
DiFMU-octanoate
Paranitrophenylbutyrate
NewsAugust-24-2022
Tree_nodeLipase_3249339

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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