Gene_Locus Report

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Gene_locus Report for: human-ACHE

Name Class
human-ACHEName Homo sapiens (Human) acetylcholinesterase
EC_number3.1.1.7
SpeciesHomo sapiens
Organismman
BlockC
FamilyACHE
Kin_Enzymehuman-ACHE
Disease_by_interactionEndplate Acetylcholinesterase deficiency; EAD
Xenobiotic_sensitivityHypersensitivity to acetylcholinesterase inhibitors
Database (16)
Paper (35)
CommentAcetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly. Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. (H322N)
Sequencehuman-ACHE
Contig_human-ACHE
human-ACHE_gene
Typecdna
Proteinhuman-ACHE
Peptidehuman-ACHE
Mutation (191)
Structure (79)
Theoretical_model2CLJ
Other_sequence (6)
Kinetic_parameter (332)
Inhibitor (108)
Substrate (6)
Reactivator7P1P-4IX
Tree_nodeACHE23781
Cholinesterase160206
Structure298124
OldTrembl (14)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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