Gene_Locus Report

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Gene_locus Report for: human-ACHE

Name Class
human-ACHEName Homo sapiens (Human) acetylcholinesterase
EC_number3.1.1.7
SpeciesHomo sapiens
Organismman
BlockC
FamilyACHE
Kin_Enzymehuman-ACHE
Disease_by_interactionEndplate Acetylcholinesterase deficiency; EAD
Xenobiotic_sensitivityHypersensitivity to acetylcholinesterase inhibitors
Database (16)
Paper (35)
CommentAcetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly. Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. (H322N)
Sequencehuman-ACHE
Contig_human-ACHE
human-ACHE_gene
Typecdna
Proteinhuman-ACHE
Peptidehuman-ACHE
Mutation (191)
Structure (79)
Theoretical_model2CLJ
Other_sequence (6)
Kinetic_parameter (332)
InhibitorCHEMBL459756
FUB833
Piperidine-4-carboxamide-alkyl-tacrine-cpd16
N,N-diethyl-4,5-dimethoxy-2-methylbenzenesulfonamide
Aurone-Donepezil-Cpd5g
Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k
Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b
Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b
Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b
Tacrine-Sibiriline-Cpd7
Tacrine-selegiline-8g
Tacrine-selegiline-7d
Di-tert-butyl-phenol-octylamino-acridine-17d
Indole-piperidine-amide-cpd23a
SB-1448
3-(Dimethylamino)-N-propanamide-Tryptanthrin
CHEMBL4207101
CHEMBL5206601
8AEV-LWU
Genistein-O-alkylbenzylamine-25d
tacrine-isatin-Cpd7k
Lycocasuarine-C
Lycocasuarinine-D
N-demethylhuperzinine
Caffeic-acid-phenethyl-ester
Propargyl-Tacrine-15
3,5-dihydroxybenzamido-huprine-hybrid-11
Phenothiazine-Tacrine-1dC
Diclofenac-derivative-39
M30D
Tacrine-pentylmethylene-tolylsulfonamide
N-10-Phenothiazine-isopropyl-carbamate
Bivalent-4-Aminopyridine-12i
Coumarin-Pyridine-3f
K-1234
Tetrabenzyl-D-glucosamine-oxadiazole-6i
Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49
4-aminopyridine-1,3,4-oxadiazole-9
N-dodecyl-pyridinyl-1,3,4-thiadiazol-amine-3t
5-pyrid-3-yl-1,3,4-oxadiazole-5e
Fluoropezil
Salicylamide-8-Tacrine
3-butyl-6-benzyloxyphthalide-Mannich-base-7d
TPPU-6-Chlorotacrine-12c
MT-031
7P1P-4IX
T-1123
Tetracyclic-triterpene-1
Tetracyclic-triterpene-36e
CHEMBL3585776
DTE-bis8-Tacrine
BisQ
AzoTHA
H0L-7D9O
H1R-7D9Q
H0R-7D9P
PE154
Hypaphorine
ZINC11996936
ZINC11709541
ACHE-GSK-3-27g
Chelerythrine
8-Hydroxydihydrochelerythrine
N-alkyl-quinuclidine-cpd14
6o-5-HT3
6ZWE-Cpd3
Tilorone
VXS
GD29
GT15
Lipocrine
TAK-802
Tanshinone-IIA
DL0410
Novichok-5~A-230
A-234-Nerve-agent
A-230-Nerve-agent
A-232-Nerve-agent
Novichok-C01-A039
Novichok-C01-A035
A-262-Nerve-agent
A-242-Nerve-agent
NTMGMP
Novichok-5~A-232
VX-Biotin
(-)-phenethylcymserine
Aricept~Donepezil~E2020
Quinolinetrione-tacrine-Cpd3
BW284C51
DFP
Edrophonium
Fasciculin2
Sanguinine
Galanthamine
HuperzineA
HuprineW
EMPA
IMP-pNP
IMP-pNP-F
NEMP
Paraoxon
Toluidine-Blue
Pyridostigmine
Sarin
Tacrine
TerritremB
Dihydrotanshinone-I
VX
Substrate (6)
Reactivator7P1P-4IX
Tree_nodeACHE23781
Cholinesterase160206
Structure298124
OldTrembl (14)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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