Gene_locus Report for: human-ACHE
human-ACHE | Name | Homo sapiens (Human) acetylcholinesterase |
| EC_number | 3.1.1.7 |
| Species | Homo sapiens |
| Organism | man |
| Block | C |
| Family | ACHE |
| Kin_Enzyme | human-ACHE |
| Disease_by_interaction | Endplate Acetylcholinesterase deficiency; EAD |
| Xenobiotic_sensitivity | Hypersensitivity to acetylcholinesterase inhibitors |
| Database (16) |
| Paper (35) |
| Comment | Acetylcholinesterase (ACHE; EC 3.1.1.7) controls synaptic and neurohumoral cholinergic activity by hydrolyzing the neurotransmitter acetylcholine. ACHE function relies on precise regulation of its expression and localization. In particular, alternative splicing of the 3-prime region of ACHE results in ACHE isoforms with distinct C-terminal peptides that determine posttranslational maturation and oligomeric assembly. Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. (H322N) |
| Sequence | human-ACHE |
| | Contig_human-ACHE |
| | human-ACHE_gene |
| Type | cdna |
| Protein | human-ACHE |
| Peptide | human-ACHE |
| Mutation (191) |
| Structure (79) |
| Theoretical_model | 2CLJ |
| Other_sequence (6) |
| Kinetic_parameter (332) |
| Inhibitor | CHEMBL459756 |
| | FUB833 |
| | Piperidine-4-carboxamide-alkyl-tacrine-cpd16 |
| | N,N-diethyl-4,5-dimethoxy-2-methylbenzenesulfonamide |
| | Aurone-Donepezil-Cpd5g |
| | Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k |
| | Coumarin-dimethoxyphenyl-methylpiperidine-carboxamise-cpd3b |
| | Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b |
| | Benzylpiperidin-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd6b |
| | Tacrine-Sibiriline-Cpd7 |
| | Tacrine-selegiline-8g |
| | Tacrine-selegiline-7d |
| | Di-tert-butyl-phenol-octylamino-acridine-17d |
| | Indole-piperidine-amide-cpd23a |
| | SB-1448 |
| | 3-(Dimethylamino)-N-propanamide-Tryptanthrin |
| | CHEMBL4207101 |
| | CHEMBL5206601 |
| | 8AEV-LWU |
| | Genistein-O-alkylbenzylamine-25d |
| | tacrine-isatin-Cpd7k |
| | Lycocasuarine-C |
| | Lycocasuarinine-D |
| | N-demethylhuperzinine |
| | Caffeic-acid-phenethyl-ester |
| | Propargyl-Tacrine-15 |
| | 3,5-dihydroxybenzamido-huprine-hybrid-11 |
| | Phenothiazine-Tacrine-1dC |
| | Diclofenac-derivative-39 |
| | M30D |
| | Tacrine-pentylmethylene-tolylsulfonamide |
| | N-10-Phenothiazine-isopropyl-carbamate |
| | Bivalent-4-Aminopyridine-12i |
| | Coumarin-Pyridine-3f |
| | K-1234 |
| | Tetrabenzyl-D-glucosamine-oxadiazole-6i |
| | Difluorophenyl-pyridin-piperazin-1,3,4-oxadiazole-49 |
| | 4-aminopyridine-1,3,4-oxadiazole-9 |
| | N-dodecyl-pyridinyl-1,3,4-thiadiazol-amine-3t |
| | 5-pyrid-3-yl-1,3,4-oxadiazole-5e |
| | Fluoropezil |
| | Salicylamide-8-Tacrine |
| | 3-butyl-6-benzyloxyphthalide-Mannich-base-7d |
| | TPPU-6-Chlorotacrine-12c |
| | MT-031 |
| | 7P1P-4IX |
| | T-1123 |
| | Tetracyclic-triterpene-1 |
| | Tetracyclic-triterpene-36e |
| | CHEMBL3585776 |
| | DTE-bis8-Tacrine |
| | BisQ |
| | AzoTHA |
| | H0L-7D9O |
| | H1R-7D9Q |
| | H0R-7D9P |
| | PE154 |
| | Hypaphorine |
| | ZINC11996936 |
| | ZINC11709541 |
| | ACHE-GSK-3-27g |
| | Chelerythrine |
| | 8-Hydroxydihydrochelerythrine |
| | N-alkyl-quinuclidine-cpd14 |
| | 6o-5-HT3 |
| | 6ZWE-Cpd3 |
| | Tilorone |
| | VXS |
| | GD29 |
| | GT15 |
| | Lipocrine |
| | TAK-802 |
| | Tanshinone-IIA |
| | DL0410 |
| | Novichok-5~A-230 |
| | A-234-Nerve-agent |
| | A-230-Nerve-agent |
| | A-232-Nerve-agent |
| | Novichok-C01-A039 |
| | Novichok-C01-A035 |
| | A-262-Nerve-agent |
| | A-242-Nerve-agent |
| | NTMGMP |
| | Novichok-5~A-232 |
| | VX-Biotin |
| | (-)-phenethylcymserine |
| | Aricept~Donepezil~E2020 |
| | Quinolinetrione-tacrine-Cpd3 |
| | BW284C51 |
| | DFP |
| | Edrophonium |
| | Fasciculin2 |
| | Sanguinine |
| | Galanthamine |
| | HuperzineA |
| | HuprineW |
| | EMPA |
| | IMP-pNP |
| | IMP-pNP-F |
| | NEMP |
| | Paraoxon |
| | Toluidine-Blue |
| | Pyridostigmine |
| | Sarin |
| | Tacrine |
| | TerritremB |
| | Dihydrotanshinone-I |
| | VX |
| Substrate (6) |
| Reactivator | 7P1P-4IX |
| Tree_node | ACHE23781 |
| | Cholinesterase160206 |
| | Structure298124 |
| OldTrembl (14) |
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