Gene_Locus Report

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Gene_locus Report for: human-AADAC

Name Class
human-AADACNameHomo sapiens (Human) arylacetamide deacetylase
SpeciesHomo sapiens
Organismman
Gene_nameAADAC
DAC
BlockH
FamilyArylacetamide_deacetylase
Database (14)
PaperWang_2022_BMC.Cancer_22_635
Shimizu_2014_Drug.Metab.Dispos_42_1103
Nourbakhsh_2013_J.Hepatol_59_336
Kobayashi_2012_Drug.Metab.Dispos_40_671
Shimizu_2012_Drug.Metab.Dispos_40_1183
Muta_2014_Biochem.Pharmacol_87_352
Probst_1994_J.Biol.Chem_269_21650
Probst_1991_Biochem.Biophys.Res.Commun_177_453
Ross_2007_J.Biochem.Mol.Toxicol_21_187
Venter_2001_Science_291_1304
Watanabe_2009_Drug.Metab.Dispos_37_1513
Muzny_2006_Nature_440_1194
Hirosawa_2021_Drug.Metab.Dispos__
Nunes_2013_Epilepsia_54_108
CommentArylacetamide deacetylase displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity
Sequencehuman-AADAC
Typecdna
Proteinhuman-AADAC
Peptidehuman-AADAC
InhibitorEpicatechin-gallate
Epigallocatechin-gallate
Vinblastine
Substrate (6)
Tree_nodeArylacetamide_deacetylase76412

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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