Type_inhibitor Report for: anti-Abeta-aggregation
| anti-Abeta-aggregation | Inhibitor (19) |
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| Comment | The main neuropathological feature of Alzhzimer's disease consist in extracellular amyloid-beta (A/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. Acetylcholinesterase is also thought to promote the aggregation. The peripheral anionic site on the surface participate in this process |
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