Type Inhibitor

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Type_inhibitor Report for: anti-Abeta-aggregation

Name Class
anti-Abeta-aggregationInhibitorCHEMBL5206601
Genistein-O-alkylbenzylamine-25d
tacrine-isatin-Cpd7k
tacrine-isatin-Cpd7d
Compound5d-Benzylpiperidine-Phenyl-oxadiazol-thiol
Compound19n-quinolinol
Donepezil-idebenone-cpd9
Phenothiazine-Tacrine-1dC
Tacrine-dipicolylamine-13a
Tetracyclic-triterpene-36e
Cpd17-Tacrine-5-HT6
Cpd35-Rivastigmine-5-HT6
MTDL-cpd51-diphenylacetamide
MTDL-cpd36-diphenylacetamide
Ass-IN-10
BIGI-3h
Chlorotacrine-tryptophan-hybrid
Quinolinetrione-tacrine-Cpd3
Chlorotacrine-juglone
CommentThe main neuropathological feature of Alzhzimer's disease consist in extracellular amyloid-beta (A/beta) plaque deposition. The critical molecular event in the AD is the accumulation of Abet neurotoxic oligomers. The proteolytic processing of Amyloid Precursor Protein (APP) by beta-secretase (beta-site APP cleaving enzyme 1, BACE1) is the rate-limiting step in the production of Abeta. Acetylcholinesterase is also thought to promote the aggregation. The peripheral anionic site on the surface participate in this process

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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