Inhibitor Report for: ZLWH-23
ZLWH-23 | Type (7) |
| Other_Name | HY-144316 |
| | CS-0379471 |
| Chemical_Nomenclature | 1-(cyclopropanecarbonylamino)-N-[2-[1-[(2-fluorophenyl)methyl]piperidin-4-yl]ethyl]-9H-pyrido[3,4-b]indole-7-carboxamide |
| Formula | C30H32FN5O2 |
| MW | 513.6 |
| |
| Paper | Liu_2021_Eur.J.Med.Chem_229_114095 |
| Comment | anti-AChE potency (IC50 = 0.27 microM) and selective BuChE inhibition (IC50 = 20.82 microM), as well as moderate GSK-3 inhibition (IC50 = 6.78 microM) |
| CID | 163322222 |
| Family | ACHE |
| InChIKey | AMLAWNFGPZNOOW-UHFFFAOYSA-N |
| CanonicalSMILES | C1CC1C(=O)NC2=NC=CC3=C2NC4=C3C=CC(=C4)C(=O)NCCC5CCN(CC5)CC6=CC=CC=C6F |
| InChI | InChI=1S/C30H32FN5O2/c31-25-4-2-1-3-22(25)18-36-15-11-19(12-16-36)9-13-33-29(37)21-7-8-23-24-10-14-32-28(27(24)34-26(23)17-21)35-30(38)20-5-6-20/h1-4,7-8,10,14,17,19-20,34H,5-6,9,11-13,15-16,18H2,(H,33,37)(H,32,35,38) |
|
|