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Inhibitor Report for: YH149
Name
Class
YH149
Type
Pyrrolidine
Piperazine
PET probe
Other_Name
81I
GLXC-25289
YH-149
Chemical_Nomenclature
(4~{R})-1-[4-(4-fluorophenyl)phenyl]-4-[4-(furan-2-ylcarbonyl)piperazin-1-yl]pyrrolidin-2-one
Formula
C25H24FN3O3
MW
433.48
Paper
Lu_2023_Lab.Chip__
He_2021_Nucl.Med.Biol_96-97_S36
He_2022_J.Med.Chem_65_2191
Structure
7PRM
Comment
(IC50= 12 nM) [18F]PF06795071 developped as a reversible MAGL PET probe
Gene_locus
human-MGLL
CID
162624754
Family
Monoglyceridelipase_lysophospholip
InChIKey
HVVLTSHAUJYILM-JOCHJYFZSA-N
CanonicalSMILES
C1CN(CCN1C2CC(=O)N(C2)C3=CC=C(C=C3)C4=CC=C(C=C4)F)C(=O)C5=CC=CO5
InChI
InChI=1S/C25H24FN3O3/c26-20-7-3-18(4-8-20)19-5-9-21(10-6-19)29-17-22(16-24(29)30)27-11-13-28(14-12-27)25(31)23-2-1-15-32-23/h1-10,15,22H,11-14,16-17H2/t22-/m1/s1
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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