Mutation Report for: Y72N/Y124Q/W286A/F295L/F297W/Y337A_human-ACHE

Y72N/Y124Q/W286A/F295L/F297W/Y337A_human-ACHE	Gene_locus	human-ACHE
	Torpedo_number (7)
	AA_Change	Y72N/Y124Q/W286A/F295L/F297W/Y337A
	Mode_of_mutation	Site directed mutagenesis
	Modification	Acyl specificity
	Summary	Acyl specificity;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE;Kaplan_2001_Biochemistry_40_7433
	Paper	Kaplan_2001_Biochemistry_40_7433
	Comment	p.Y72N/Y124Q/W286A/F295L/F297W/Y337A Tyr72Asn/Tyr124Gln/Trp286Ala/Phe295Leu/Phe297Val/Tyr337Ala (p.Y103N/Y155Q/W317A/F326L/F328W/Y368A Tyr103Asn/Tyr155Gln/Trp317Ala/Phe326Leu/Phe328Val/Tyr368Ala in primary sequence with 31 amino-acids signal peptide) Acyl specificity; replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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