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Mutation Report for: Y72A_human-ACHE

Name Class
Y72A_human-ACHEGene_locushuman-ACHE
Torpedo_number70
AA_ChangeY72A
Mode_of_mutationSite directed mutagenesis
ModificationOmega loop
Peripheral Anionic Site
SummaryOmega loop;No effect;Velan_1996_FEBS.Lett_395_22
Peripheral Anionic Site;Increase inhibition by PAS ligands;Barak_1994_J.Biol.Chem_269_6296
PaperVelan_1996_FEBS.Lett_395_22
Barak_1994_J.Biol.Chem_269_6296
Kinetic_parameterAcetylthiocholine_Y72A_human-ACHE
Edrophonium_Y72A_human-ACHE
Hexamethonium_Y72A_human-ACHE
BW284C51_Y72A_human-ACHE
Propidium_Y72A_human-ACHE
Decamethonium_Y72A_human-ACHE
Commentp.Y72A Tyr72Ala (p.Y103A Tyr103Ala in primary sequence with 31 amino-acids signal peptide) Omega loop: No effect, Peripheral Anionic Site: Increase inhibition by PAS ligands
Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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