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Mutation Report for: Y72A/Y124A_human-ACHE

Name Class
Y72A/Y124A_human-ACHEGene_locushuman-ACHE
Torpedo_number70,121
70
121
AA_ChangeY72A/Y124A
Mode_of_mutationSite directed mutagenesis
ModificationPeripheral Anionic Site
SummaryPeripheral Anionic Site;small effect on Km and kcat, resistance to inhibition;Barak_1994_J.Biol.Chem_269_6296;Shafferman_1995_5th.ChE.Meeting.Madras__189
PaperBarak_1994_J.Biol.Chem_269_6296
Shafferman_1995_5th.ChE.Meeting.Madras__189
Kinetic_parameter (6)
Commentp.Y72A/Y124A Tyr72Ala/Tyr124Ala (p.Y103A/Y155A Tyr103Ala/Tyr155Ala in primary sequence with 31 amino-acids signal peptide) Peripheral Anionic Site;small effect on Km and kcat, resistance to inhibition
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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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