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Mutation Report for: Y337F_mouse-ACHE

Name Class
Y337F_mouse-ACHEGene_locusmouse-ACHE
Torpedo_number330
AA_ChangeY337F
Mode_of_mutationSite directed mutagenesis
ModificationSignal transduction
Substrate inhibition
Aricept~Donepezil~E2020 inhibition
SummarySignal transduction;less effect than Y337A on occlusion of ethopropazine binding site;Radic_1993_Biochemistry_32_12074;Saxena_1994_Protein.Sci_3_1770
Substrate inhibition;less effect than Y337A on occlusion of ethopropazine binding site;Radic_1993_Biochemistry_32_12074;Saxena_1994_Protein.Sci_3_1770
Aricept~Donepezil~E2020 inhibition;decrease Ki vs WT;Saxena_2003_Eur.J.Biochem_270_4447
Paper (5)
Kinetic_parameter (10)
Commentp.Tyr337Phe
Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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