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Mutation Report for: Y337A_mouse-ACHE
Name
Class
Y337A_mouse-ACHE
Gene_locus
mouse-ACHE
Torpedo_number
330
AA_Change
Y337A
Mode_of_mutation
Site directed mutagenesis
Modification
Signal transduction
Substrate inhibition
Oxime interaction
Aricept~Donepezil~E2020 inhibition
Summary
Signal transduction;responsible for the 1800 fold difference in Ki for ethopropazine AChE/BChE;Radic_1993_Biochemistry_32_12074;Radic_1994_J.Biol.Chem_269_11233;Saxena_1994_Protein.Sci_3_1770
Aricept~Donepezil~E2020 inhibition;decrease Ki vs WT;Saxena_2003_Eur.J.Biochem_270_4447
Oxime interaction;enlargement of the active site of the gorge;Kovarik_2006_Biochem.Biophys.Res.Commun_342_973;Kovarik_2007_Toxicology_233_79
Oxime interaction;;Kovarik_2004_Biochemistry_43_3222
Paper (10)
Kinetic_parameter (11)
Structure (9)
News
DECEMBER-08-2010
Comment
enlargement of the active site of the gorge
p.Tyr337Ala
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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