p.Y337A Tyr337Ala (p.Y368A Tyr368Ala in primary sequence with 31 amino-acids signal peptide);Decrease in catalytic and apparent bimolecular constant Substrate inhibition;absence of substrate inhibition; Acyl specificity;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE; Oxime interaction; reactivation of tabun-inhibited human AChE. Unable to facilitate HI-6-mediated reactivation of tabun-hAChE; The phosphoramidated-hAChE choline-binding site mutant Y337A showed three-times enhanced reactivation capacity with non-triazole imidazole containing aldoximes than with 2PAM