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Mutation Report for: Y124Q_human-ACHE

Name Class
Y124Q_human-ACHEGene_locushuman-ACHE
Torpedo_number121
AA_ChangeY124Q
Mode_of_mutationSite directed mutagenesis
ModificationAcyl specificity
SummaryAcyl specificity;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE;Kaplan_2001_Biochemistry_40_7433
PaperKaplan_2001_Biochemistry_40_7433
Kinetic_parameterAcetylthiocholine_Y124Q_human-ACHE
Butyrylthiocholine_Y124Q_human-ACHE
CommentY124Q p.Tyr124Gln (Y155Q p.Tyr155Gln in primary sequence with 31 amino-acids signal peptide) Acyl specificity;replacement of aromatic active center residues in human-ACHE by the corresponding residues in human-BCHE
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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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