Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: WWL123

Name Class
WWL123TypeCarbamate
Biphenyl
Other_Name (6)
Chemical_Nomenclature[3-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-phenylphenyl)methyl]carbamate
FormulaC28H24N2O3
CAS_number1338574-83-6
1338575-41-9
MW436.50
PaperZhong_2011_J.Physiol_589_4847
Naydenov_2014_Neuron_83_361
Comment(Differs from WWL70 only by a phenyl instead of a pyridine). Brain-penetrant inhibitor of ABHD6 hydrolysis of cannabinoid 2-Arachidonylglycerol (IC50 = 0.43 uM). Inhibition of ABHD6 by WWL123 has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington's disease as well as in chemically-induced epilepsy models. But relation to Cannabinoid pathway discussed. There are discrepencies in the structures presented between 3-yl and 4-yl isomers
CID53364549
FamilyABHD6-Lip
InChIKeyQKMMESWNJMOPIF-UHFFFAOYSA-N
CanonicalSMILESCN(CC1=CC=CC(=C1)C2=CC=CC=C2)C(=O)OC3=CC=CC(=C3)C4=CC=C(C=C4)C(=O)N
InChIInChI=1S/C28H24N2O3/c1-30(19-20-7-5-10-24(17-20)21-8-3-2-4-9-21)28(32)33-26-12-6-11-25(18-26)22-13-15-23(16-14-22)27(29)31/h2-18H,19H2,1H3,(H2,29,31)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer