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Mutation Report for: W86A_human-ACHE

Name Class
W86A_human-ACHEGene_locushuman-ACHE
Torpedo_number84
AA_ChangeW86A
Mode_of_mutationSite directed mutagenesis
ModificationCholine binding site
Signal transduction
SummaryCholine binding site;Choline binding site/signal transductioncation-aromatic interaction, 660 fold decrease affinity for ACTh no effect on uncharged substrate,;Shafferman_1992_EMBO.J_11_3561;Shafferman_1992_4th.ChE.Meeting.Eilat__165;Ordentlich_1993_J.Biol.Chem_268_17083;Shafferman_1993_Proc.Med.Def.Biosci.Rev_3_1097;Barak_1994_J.Biol.Chem_269_6296;Kronman_1994_J.Biol.Chem_269_27819
Signal transduction;Y133 maintains the correct orientation of W86;Shafferman_1995_5th.ChE.Meeting.Madras__189;Ordentlich_1995_J.Biol.Chem_270_2082;Shafferman_1996_Biochem.J_318_833
Paper (10)
Kinetic_parameter (11)
Commentp.W86A Trp86Ala (p.W117A Trp117Ala in primary sequence with 31 amino-acids signal peptide) Choline binding site/signal transductioncation-aromatic interaction, 660 fold decrease affinity for ACTh no effect on uncharged substrate, Y133 maintains the correct orientation of W86

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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