Mutation Report for: W82A_human-BCHE

W82A_human-BCHE	Gene_locus	human-BCHE
	Torpedo_number	84
	AA_Change	W82A
	Mode_of_mutation	Site directed mutagenesis
	Modification	Succinylthiocholine binding
		Substrate activation
		Aricept~Donepezil~E2020 inhibition
	Summary	Succinylthiocholine binding;No binding of succinylthiocholine;Masson_1997_Biochemistry_36_2266
		Substrate activation;substrate activation;Masson_2001_Biochim.Biophys.Acta_1544_166
		Aging;W82A increases half-life of aging by DFP 13 times;Masson_1997_Biochem.J_327_601
		Aricept~Donepezil~E2020 inhibition;no inhibition at >120uM;Saxena_2003_Eur.J.Biochem_270_4447
	Paper (5)
	Comment	p.W82A Trp82Ala (p.W110A Trp110Ala in primary sequence with 28 amino-acids signal peptide) No binding of succinylthiocholine Aging: W82A increases half-life of aging by DFP 13 times, Aricept~Donepezil~E2020 inhibition: no inhibition at >120uM

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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