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Mutation Report for: W82A_human-BCHE

Name Class
W82A_human-BCHEGene_locushuman-BCHE
Torpedo_number84
AA_ChangeW82A
Mode_of_mutationSite directed mutagenesis
ModificationSuccinylthiocholine binding
Substrate activation
Aricept~Donepezil~E2020 inhibition
Summary (4)
Paper (5)
Commentp.W82A Trp82Ala (p.W110A Trp110Ala in primary sequence with 28 amino-acids signal peptide) No binding of succinylthiocholine Aging: W82A increases half-life of aging by DFP 13 times, Aricept~Donepezil~E2020 inhibition: no inhibition at >120uM

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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