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Inhibitor Report for: VX-Biotin

Name Class
VX-BiotinType (6)
FormulaC30H60N4O4PS2+
MW635.93
PaperBouknight_2020_Biochem.Pharmacol__113980
Carmany_2017_Chem.Res.Toxicol_30_1076
CommentSerine Hydrolase probe consisting of a tag linked to a VX group, whichcovalently labels serine of enzymatically active serine hydrolases. ABPP-Probe (activity based protein profiling probe). Useful as ABPP probe but not specific: Labels lots of non serine hydrolases
Gene_locushuman-CTSA
human-ACHE
human-BCHE
Family (19)
InChIKeyIFUSBFMUVYCLLZ-UHFFFAOYSA-O
CanonicalSMILES[P](C)(SCC[N+](C(C)C)C(C)C)(=O)OCCCCCCCCCCCNC(CCCCC1C2C(CS1)NC(N2)=O)=O
InChIInChI=1S/C30H59N4O4PS2/c1-24(2)34(25(3)4)20-22-41-39(5,37)38-21-16-12-10-8-6-7-9-11-15-19-31-28(35)18-14-13-17-27-29-26(23-40-27)32-30(36)33-29/h24-27,29H,6-23H2,1-5H3,(H,31,35)(H2,32,33,36)/p+1

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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