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Substrate Report for: VPA-glucuronide

Name Class
VPA-glucuronideTypeGlucuronide
Other_Name (6)
Chemical_Nomenclature(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-propylpentanoyloxy)oxane-2-carboxylic acid
FormulaC14H24O8
CAS_number60113-83-9
MW320.34
PaperSuzuki_2010_Drug.Metab.Dispos_38_1538
Masuo_2010_Drug.Metab.Dispos_38_1828
Nakamura_2008_Drug.Metab.Lett_2_280
Mori_2007_Drug.Metab.Rev_39_647
CommentACPH_Peptidase_S9: VPA-glucuronidase is responsible for maintaining the serum concentration of VPA, by cleaving its major metabolic product, valproic acid-beta-(d)-glucuronide (VPA-G),2 releasing VPA allowing its reabsorption. This enzyme is inhibited by carbapenems
Gene_locuspig-acph
CID88111
FamilyACPH_Peptidase_S9
InChIKeyXXKSYIHWRBBHIC-JVWRJRKNSA-N
CanonicalSMILESCCCC(CCC)C(=O)OC1C(C(C(C(O1)C(=O)O)O)O)O
InChIInChI=1S/C14H24O8/c1-3-5-7(6-4-2)13(20)22-14-10(17)8(15)9(16)11(21-14)12(18)19/h7-11,14-17H,3-6H2,1-2H3,(H,18,19)/t8-,9-,10+,11-,14-/m0/s1

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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