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Inhibitor Report for: Tz2

Name Class
Tz2TypeAcridine
Derivative of Tacrine
Azido
Other_Name1-Azido-ethyl-2-amino-N'-9'-(1',2',3'4,'-tetrahydroacridinyl) hydrochloride
Chemical_NomenclatureN-(2-azidoethyl)-1,2,3,4-tetrahydroacridin-9-amine
FormulaC15H17N5
MW267.33
PaperBourne_2016_J.Am.Chem.Soc_138_1611
Bourne_2004_Proc.Natl.Acad.Sci.U.S.A_101_1449
Lewis_2002_Angew.Chem.Int.Ed.Engl_41_875
Lewis_2002_Angew.Chem.Int.Ed.Engl_41_1053
Structure5EIH
5EIE
CommentAChE Active site inhibitor (tacrine) equipped with an azide group at the end of a methylene chain used as building block of 1,3-dipolar cycloaddition (click chemistry) with a PAS inhibitor (phenylphenanthridinium) equipped with an acatylene group at the end of a flexible methylene chain
Gene_locusmouse-ACHE
CID86032728
FamilyACHE
InChIKeyANJRGTMSMVLPLB-UHFFFAOYSA-N
CanonicalSMILESC1CCC2=NC3=CC=CC=C3C(=C2C1)NCCN=[N+]=[N-]
InChIInChI=1S/C15H17N5/c16-20-18-10-9-17-15-11-5-1-3-7-13(11)19-14-8-4-2-6-12(14)15/h1,3,5,7H,2,4,6,8-10H2,(H,17,19)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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