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Reactivator Report for: Tryptoline-hydroxy-pyridinaldoxime-3

Name Class
Tryptoline-hydroxy-pyridinaldoxime-3Type (2)
Chemical_Nomenclature2-[(E)-hydroxyiminomethyl]-6-[4-(1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl)butyl]pyridin-3-ol
FormulaC21H24N4O2
MW364.4
PaperRenou_2014_Chem.Commun.(Camb)_50_3947
CommentCompound 4 is as efficient as HI-6 for VX-hAChE, while3 equals trimedoxime for tabun-hAChE.In comparison with pralidoxime,3 and 4 are up to 30-fold more efficient for VX-AChE, up to 60-fold more efficient for tabun-AChE and up to 10-fold more efficient for paraoxon-AChE
CID136268843
InChIKeyQLEXOXFYVLIIIR-LPYMAVHISA-N
CanonicalSMILESC1CN(CC2=C1C3=CC=CC=C3N2)CCCCC4=NC(=C(C=C4)O)C=NO
InChIInChI=1S/C21H24N4O2/c26-21-9-8-15(23-19(21)13-22-27)5-3-4-11-25-12-10-17-16-6-1-2-7-18(16)24-20(17)14-25/h1-2,6-9,13,24,26-27H,3-5,10-12,14H2/b22-13+

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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