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Inhibitor Report for: TFAH-tacrine-ferulic-acid-hybrid-10n

Name Class
TFAH-tacrine-ferulic-acid-hybrid-10nTypeMultitarget
Acrylate
Antioxidant
Derivative of Tacrine
Hydroxycinnamic-ester
Alkyl linked bis-ligand
Other_Name(E)-3-(hydroxy-3-methoxyphenyl)-N-{8[(7-methoxy-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl}-N-[2-(naphthalen-2-ylamino)2-oxoethyl]acrylamide
CHEMBL4552675
BDBM50510850
Chemical_Nomenclature(E)-3-(4-hydroxy-3-methoxyphenyl)-N-[8-[(7-methoxy-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-N-[2-(naphthalen-2-ylamino)-2-oxoethyl]prop-2-enamide
FormulaC44H50N4O5
MW714.9
PaperBenchekroun_2015_ChemMedChem_10_523
CommentBCHE IC50=68.2 nM
CID132281442
FamilyBCHE
InChIKeyCIMNCRAYKQYYMB-HKOYGPOVSA-N
CanonicalSMILESCOC1=CC2=C(C=C1)N=C3CCCCC3=C2NCCCCCCCCN(CC(=O)NC4=CC5=CC=CC=C5C=C4)C(=O)C=CC6=CC(=C(C=C6)O)OC
InChIInChI=1S/C44H50N4O5/c1-52-35-21-22-39-37(29-35)44(36-15-9-10-16-38(36)47-39)45-25-11-5-3-4-6-12-26-48(43(51)24-18-31-17-23-40(49)41(27-31)53-2)30-42(50)46-34-20-19-32-13-7-8-14-33(32)28-34/h7-8,13-14,17-24,27-29,49H,3-6,9-12,15-16,25-26,30H2,1-2H3,(H,45,47)(H,46,50)/b24-18+

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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