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Mutation Report for: T284N/P285K/L286S/S287N_human-BCHE

Name Class
T284N/P285K/L286S/S287N_human-BCHEGene_locushuman-BCHE
Torpedo_number (5)
AA_ChangeT284N/P285K/L286S/S287N
Mode_of_mutationSite directed mutagenesis
Modification (2)
SummarySearch for phosphotriesterase activity;;Terekhov_2017_Proc.Natl.Acad.Sci.U.S.A_114_2550
PaperTerekhov_2017_Proc.Natl.Acad.Sci.U.S.A_114_2550
Commentp.T284N/P285K/L286S/S287N Thr284Asn/Pro285Lys/Leu286Ser/Ser287Asn (p.T312N/P313K/L314S/S315N Thr312Asn/Pro313Lys/Leu314Ser/Ser315Asn in primary sequence with 28 amino-acids signal peptide) Multiple amino acid substitutions in the acyl-binding loop 284-TPLSV-288 284-ThrProLeuSerVal-288 close to the active site. replaced by ProProLeuArgSer QSIHI clone 13. Slow self-reactivation after inhibition by paraoxon

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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