The final programme of 12th Meeting on Cholinesterases together with the Sixth International Conference on Paraoxonases (27 Sept - 2 Oct 2015), Elche (Alicante) , Spain is available: Visit the web site: 12th ChE. Structure of Torpedo californica Acetylcholinesterase in complex with a tacrine-benzofuran hybrid inhibitor is available (4W63) and will soon be published by Paresi et al. A conformational change in the peripheral anionic site of Torpedo californica acetylcholinesterase induced by a Bis-imidazolium Oxime (2BIM-7, Ortho-7) is published by Legler et al. and structures are available (5BWB; 5BWC). PRIMA1 mutation: a new cause of nocturnal frontal lobe epilepsy is published by Hildebrand et al. A COLQ missense mutation in Sphynx and Devon Rex Cats with Congenital myasthenic syndrome is described by Abitbol et al. A rationally designed mutant (W298H) of plasma platelet-activating factor acetylhydrolase (human-PLA2G7) which hydrolyzes the organophosphorus nerve agent soman is published by Kirby et al.