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Inhibitor Report for: Salicylamide-8-Tacrine

Name Class
Salicylamide-8-TacrineType (5)
Other_Name6d
Chemical_NomenclatureN-(8-(1,2,3,4-tetrahydroacridin-9-ylamino)octyl)salicylamide
FormulaC28H35N3O2
MW445.60
PaperGrishchenko_2022_ChemMedChem__e202200080
CommentHuman RBC AChE, IC50 [microM] 0.224+/-0.017; Equine Serum BChE, IC50 [microM] 0.0104+/-0.0013; Porcine Liver CES, [%inhibition at 20microM] 29.5+/-2.5
Gene_locushuman-ACHE
human-BCHE
FamilyACHE
BCHE
InChIKeyLZLGDQZILKXGLJ-UHFFFAOYSA-N
CanonicalSMILESC1=CC=C2C(=C1)C=C3C(=N2)CCCC3NCCCCCCCCNC(=O)C4=C(C=CC=C4)O
InChIInChI=1S/C28H35N3O2/c32-27-17-8-6-13-22(27)28(33)30-19-10-4-2-1-3-9-18-29-25-15-11-16-26-23(25)20-21-12-5-7-14-24(21)31-26/h5-8,12-14,17,20,25,29,32H,1-4,9-11,15-16,18-19H2,(H,30,33)

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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