Type_substrate Report for: Polyketide
| Polyketide | Substrate (5) |
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| Comment | Polyketides are produced in bacteria, fungi, plants, and certain marine animals. The biosynthesis involves stepwise condensation of acetyl-CoA or propionyl-CoA with either malonyl-CoA or methylmalonyl-CoA. Polyketides are synthesized by multienzyme polypeptides that resemble eukaryotic fatty acid synthase but are often much larger. They include acyl-carrier domains plus an assortment of enzymatic units that can function in an iterative fashion, repeating the same elongation/modification steps (as in fatty acid synthesis), or in a sequential fashion so as to generate more heterogeneous types of polyketides. The last reaction is often performed by a thioesterase |
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