Inhibitor

Bibliography

Biblio print

Tree Display

AceDB Schema

XML Display

Feedback

Inhibitor Report for: Piperidinyl-1,2,3-triazole-urea-inhibitor-2

Name Class
Piperidinyl-1,2,3-triazole-urea-inhibitor-2TypePiperidine
Urea derivative
Triazol
Other_NameBDBM195571
(R)-4'-(2-(2-phenylpiperidine-1-carbonyl)-2H-1,2,3-triazol-4-yl)-[1,1'-biphenyl]-4-carboxylic acid (2)
Chemical_Nomenclature4-[4-[2-[(2R)-2-phenylpiperidine-1-carbonyl]triazol-4-yl]phenyl]benzoic acid
FormulaC27H24N4O3
MW452.51
Pick_me_to_calldisplay_scriptPiperidinyl-1,2,3-triazole-urea-inhibitor-2
PaperAhn_2016_ACS.Chem.Biol_11_2529
Structure5KRE
CommentN1-substituted triazole urea previously disclosed as an inhibitor of ABHD6 KT195 was modified as N2-substituted isomer and shown to inhibit LYPLAL1. The compound 2 inhibited also other alpha/beta hydrolases and some SGNH hydrolase-type esterase (PAFAH1B2-3), but compound 11 and 12 are specific. The adduct in the structure is the small (R)-2-phenylpiperidine-1-carbonyl
Gene_locushuman-LYPLAL1
CID122172786
Family (5)
InChIKeyDMGNPPFKBOMVQC-RUZDIDTESA-N
CanonicalSMILESC1CCN(C(C1)C2=CC=CC=C2)C(=O)N3N=CC(=N3)C4=CC=C(C=C4)C5=CC=C(C=C5)C(=O)O
InChIInChI=1S/C27H24N4O3/c32-26(33)23-15-11-20(12-16-23)19-9-13-21(14-10-19)24-18-28-31(29-24)27(34)30-17-5-4-8-25(30)22-6-2-1-3-7-22/h1-3,6-7,9-16,18,25H,4-5,8,17H2,(H,32,33)/t25-/m1/s1

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer