Inhibitor Report for: Phthalimido-Galanthaminium-8d
| Phthalimido-Galanthaminium-8d | Type (6) |
|---|
| Other_Name (6) |
| Chemical_Nomenclature | 2-[8-[[(1S,12S,14R)-14-hydroxy-4-methyl-11-oxa-4-azoniatetracyclo[8.6.1.01,12.06,17]heptadeca-4,6(17),7,9,15-pentaen-9-yl]oxy]octyl]isoindole-1,3-dione |
| Formula | C32H37N2O5 |
| MW | 529.27 |
|  |
| Paper | Greenblatt_2004_J.Am.Chem.Soc_126_15405 |
| | Mary_1998_Bioorg.Med.Chem_6_1835 |
| Comment | IC50 0.7 +/- 0.1 (10-7 M) Comparable to Tacrine , more potent than Galanthamine (Mary et al.1998).Structure of torca-ACHE inhibited Greenblatt_2004 1W76 |
| CID | 23645164 |
| Family | ACHE |
| InChIKey | VFRNWNIHKJCFTE-BHRZLAGCSA-N |
| CanonicalSMILES | C[N+]1=CC2=C3C(=C(C=C2)OCCCCCCCCN4C(=O)C5=CC=CC=C5C4=O)OC6C3(CC1)C=CC(C6)O |
| InChI | InChI=1S/C32H37N2O5/c1-33-18-16-32-15-14-23(35)20-27(32)39-29-26(13-12-22(21-33)28(29)32)38-19-9-5-3-2-4-8-17-34-30(36)24-10-6-7-11-25(24)31(34)37/h6-7,10-15,21,23,27,35H,2-5,8-9,16-20H2,1H3/q+1/t23-,27-,32-/m0/s1 |
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