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Substrate Report for: PAF-2-Thio
Name
Class
PAF-2-Thio
Type
Trimethylammonium
Choline ester
Other_Name (5)
Chemical_Nomenclature
[(2R)-2-acetylsulfanyl-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
Formula
C26H54NO6PS
CAS_number
74389-68-7
96801-55-7
MW
539.74
Pick_me_to_call
display_script
PAF-2-Thio
Paper
Aarsman_1991_Eur.J.Biochem_200_187
Zuliani_2023_Antioxidants.(Basel)_12_597
Stewart_1991_J.Lipid.Mediat_4_299
Comment
PAF-2-Thio is a synthetic substrate for lysophospholipase II and for PAF-Acetyl hydrolase. In the Ellman reaction (the free thiol product of reaction is detected colorimetrically with the DTNB reagent)
Gene_locus
human-PLA2G7
CID
10347222
Family
PAF-Acetylhydrolase
LYsophospholipase_carboxylesterase
InChIKey
YPPZOKNKENLFTE-AREMUKBSSA-N
CanonicalSMILES
CCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)SC(=O)C
InChI
InChI=1S/C26H54NO6PS/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(35-25(2)28)24-33-34(29,30)32-22-20-27(3,4)5/h26H,6-24H2,1-5H3/t26-/m1/s1
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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